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Journal articles
Does the progesterone receptor genetic polymorphism +331G/A hPR influence the risk of venous thromboembolism among postmenopausal women using hormone therapy? The ESTHER Study.
Abstract : Hormone therapy (HT) increases venous thromboembolism (VTE) risk among postmenopausal women. Data on the influence of steroids receptors polymorphisms on this association remain scarce. Since progesterone receptor (hPR) is expressed in human veins and specific progestogens increase VTE risk, we investigated the impact of the functional +331G/A hPR polymorphism on the association of VTE with HT. Using the data of the ESTHER study, we showed that ORs for VTE in current users of progesterone or progestins were not significantly different by hPR+331G/A genotype status. hPR polymorphism appears not to have a significant effect on VTE risk related to HT.
Cited literature [8 references]
https://www.hal.inserm.fr/inserm-01142841
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Submitted on : Thursday, April 16, 2015 - 10:03:47 AM
Last modification on : Sunday, June 26, 2022 - 12:03:20 PM
Long-term archiving on: : Monday, September 14, 2015 - 9:36:22 AM
Contributor : Pascale SZTAJNBOK Connect in order to contact the contributor
Submitted on : Thursday, April 16, 2015 - 10:03:47 AM
Last modification on : Sunday, June 26, 2022 - 12:03:20 PM
Long-term archiving on: : Monday, September 14, 2015 - 9:36:22 AM
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Bouaziz_Maturitas_2009.pdf
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