Does the progesterone receptor genetic polymorphism +331G/A hPR influence the risk of venous thromboembolism among postmenopausal women using hormone therapy? The ESTHER Study.

Elodie Bouaziz; Marianne Canonico; Céline Verstuyft; Laure Carcaillon; Frédéric Martin; Pierre-Yves Scarabin; Anne Guiochon-Mantel

doi:10.1016/j.maturitas.2009.08.013

Does the progesterone receptor genetic polymorphism +331G/A hPR influence the risk of venous thromboembolism among postmenopausal women using hormone therapy? The ESTHER Study.

Elodie Bouaziz ¹ Marianne Canonico ² Céline Verstuyft ^{1, 3} Laure Carcaillon ² Frédéric Martin ¹ Pierre-Yves Scarabin ² Anne Guiochon-Mantel ^{1, 4}

1 Service de génétique moléculaire, pharmacogénétique et hormonologie

2 Recherche en épidémiologie et biostatistique

3 Département de pharmacologie

4 Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique

Abstract : Hormone therapy (HT) increases venous thromboembolism (VTE) risk among postmenopausal women. Data on the influence of steroids receptors polymorphisms on this association remain scarce. Since progesterone receptor (hPR) is expressed in human veins and specific progestogens increase VTE risk, we investigated the impact of the functional +331G/A hPR polymorphism on the association of VTE with HT. Using the data of the ESTHER study, we showed that ORs for VTE in current users of progesterone or progestins were not significantly different by hPR+331G/A genotype status. hPR polymorphism appears not to have a significant effect on VTE risk related to HT.

Keywords : hormone therapy venous thromboembolism Key terms: progesterone receptor

Type de document :

Article dans une revue

Maturitas, Elsevier, 2009, 64 (2), pp.136-8. 〈10.1016/j.maturitas.2009.08.013〉

Domaine :

Sciences du Vivant [q-bio]

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

Liste complète des métadonnées

Littérature citée [8 références] Voir Masquer Télécharger

http://www.hal.inserm.fr/inserm-01142841
Contributeur : Pascale Sztajnbok <>
Soumis le : jeudi 16 avril 2015 - 10:03:47
Dernière modification le : mercredi 29 novembre 2017 - 09:31:52
Document(s) archivé(s) le : lundi 14 septembre 2015 - 09:36:22

Bouaziz_Maturitas_2009.pdf

Fichiers produits par l'(les) auteur(s)

Does the progesterone receptor genetic polymorphism +331G/A hPR influence the risk of venous thromboembolism among postmenopausal women using hormone therapy? The ESTHER Study.

Fichier

Identifiants

Collections

Citation

Exporter

Métriques

155

104

Contact

Does the progesterone receptor genetic polymorphism +331G/A hPR influence the risk of venous thromboembolism among postmenopausal women using hormone therapy? The ESTHER Study.

Fichier

Identifiants

Collections

Citation

Exporter

Partager

Métriques

155

104

Contact