The DNA Damage Response: Making It Safe to Play with Knives, Molecular Cell, vol.40, issue.2, pp.179-204, 2010. ,
DOI : 10.1016/j.molcel.2010.09.019
When bacteria become mutagenic and carcinogenic: Lessons from H. pylori, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.703, issue.1, pp.66-70, 2010. ,
DOI : 10.1016/j.mrgentox.2010.07.014
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells, Science, vol.313, issue.5788, pp.848-851, 2006. ,
DOI : 10.1126/science.1127059
Cell Chromatin remodeling at DNA double-strand breaks, Cell, vol.14, pp.1344-1354, 2013. ,
DNA Damage, DNA Repair and Cancer, pp.978-953, 2013. ,
DOI : 10.5772/53919
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair, The Journal of Cell Biology, vol.4, issue.3, pp.579-595, 2013. ,
DOI : 10.1016/j.tibs.2011.01.006
H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy, Proceedings of the National Academy of Sciences, vol.103, issue.48, pp.18137-1842, 1999. ,
DOI : 10.1073/pnas.0608709103
Highresolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome Helicobacter pylori in health and disease, EMBO Cover TL, Blaser MJ Gastroenterology, vol.29, issue.136, pp.1446-1457, 2009. ,
Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells Helicobacter pylori infection generates genetic instability in gastric cells, Gastroenterology Clin Cancer Res Machado AM Biochem Biophys Acta, vol.123, issue.1806, pp.542-553, 2002. ,
Chronic Helicobacter pylori infections induce gastric mutations in mice Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability, Gastroenterology J Biol Chem, vol.124, issue.284, pp.1408-1419, 2003. ,
Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells, Gastroenterology, vol.139, issue.4, pp.1333-1343, 2010. ,
DOI : 10.1053/j.gastro.2010.06.018
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host, Proceedings of the National Academy of Sciences, vol.108, issue.22, 2011. ,
DOI : 10.1073/pnas.1106200108
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells The population genetics of commensal Escherichia coli Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells) Physiological and pathological consequences of cellular senescence Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype, Proc Natl Acad Sci Nat Rev Microbiol Proc Natl Acad Sci PLoS One Cell Mol LifeGut, vol.108, issue.63, pp.9238-9243, 2010. ,
Genetic structure of the colibactin genomic island among members of the family Enterobacteriaceae, Infect Immun, vol.77, pp.4696-4703, 2009. ,
Genotoxic Klebsiella pneumoniae in Taiwan The microbiome and cancer Intestinal inflammation targets cancer-inducing activity of the microbiota Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation, PLOS one Nat Rev Cancer Science Raisch J, Buc E, Bonnet M World J Gastroenterol, vol.9, issue.20, pp.800-812120, 2012. ,
Microbial genomic analysis reveals the essential role of inflammation in bacteriainduced colorectal cancer Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity In vivo evidence for a prodrug activation mechanism during colibactin maturation Isolation of a metabolite from pks island provides insights into colibactin biosynthesis and activity (2014) Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein, Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation, pp.501-509, 1997. ,
The Biology of the Cytolethal Distending Toxins, Toxins, vol.3, issue.12, pp.172-190, 2011. ,
DOI : 10.3390/toxins3030172
The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling, Cell Microbiol Cell Microbiol J Cell Mol Med, vol.4, issue.14, pp.87-99, 2002. ,
Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts, DNA Repair, vol.18, issue.276, pp.31-43, 2001. ,
DOI : 10.1016/j.dnarep.2014.03.002
Genome-wide analysis of cellular response to bacterial genotoxin CdtB in yeast From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin, Infect Immun Cell Microbiol, vol.75, issue.15, pp.1393-14021, 2013. ,
The cytolethal distending toxin effects on mammalian cells: a DNA damage perspective Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response Pseudomonas aeruginosa: a formidable and ever-present adversary, Cells Cell Microbiol, vol.3, issue.15, pp.592-615, 2009. ,
Emerging resistant Gram-negative aerobic bacilli in hospital-acquired infections Keeping their options open: acute versus persistent infections Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa, J Hosp Infect Chemotherapy J Bacteriol J Infect Dis Rello J Crit Care Med, vol.73, issue.30, pp.338-344, 2001. ,
The type III secretion system of Pseudomonas aeruginosa: infection by injection, Nature Reviews Microbiology, vol.67, issue.9, pp.654-665, 2009. ,
DOI : 10.1038/nrmicro2199
Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice Base-excision repar of oxidative DNA damage Song J, Bent AF (2014) Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity Markou P, Apidianakis Y (2014) Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer 58. The Human Microbiome Projet Consortium (2012) Structure, function and diversity of the healthy human microbiome Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units, Infect Immun Nature PLOS Pathog Nature Front Cell Infect Microbiol Nature Intensive Care Med Bergounioux J, vol.79, issue.60, pp.75-87, 2001. ,
Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium's epithelial niche, Cell Host Microbe, vol.11, pp.240-252, 2012. ,
To die or not to die: Shigella has an answer Word Health Organization, department of reproductive health and research (2012) Emergence of multi-drug resistant Neisseria gonorrhoeae. Threat of global rise in untreatable sexually transmitted infections. WHO reference number, Cell Host Microbe, vol.1111, issue.624, pp.219-221, 2012. ,
Neisseria gonorrhoeae infection causes DNA damage and affects the expression of p21, p27 and p53 in non-tumor epithelial cells Listeria monocytogenes induces host DNA damage and delays the host cell cycle to promote infection, J Cell Sci Cell Cycle PLoS Pathog, vol.126, issue.1010, pp.339-347, 2013. ,
Listeriolysin O Suppresses Phospholipase C-Mediated Activation of the Microbicidal NADPH Oxidase to Promote Listeria monocytogenes Infection, Cell Host & Microbe, vol.10, issue.6, pp.627-634, 2011. ,
DOI : 10.1016/j.chom.2011.11.005
Chlamydial intracellular survival strategies. Cold Spring Harb Perspect Med 3: a010256. 69 Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response (2014) Tumor suppressor p53 alters host cell metabolism to limit Chlamydia trachomatis infection, Cell Host Microbe Cell Reports, vol.13, issue.71, pp.746-758, 2013. ,
Chlamydia trachomatis inhibits telomeric DNA damage signaling via transient hTERT upregulation, Nat Commun, 2013. ,
Scaling of immune responses against intracellular bacterial infection Immune sensing of DNA DNA damage and innate immunity: links and trade-offs IFI16: At the interphase between innate DNA sensing and genome regulation, EMBO J. Paldudan SR Immunity Trends Immunol. Cytokine Growth Factor Rev, vol.33, issue.25, pp.2283-2294, 2013. ,
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking, NO (2015) DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity, pp.2969-2974, 2012. ,
DOI : 10.1073/pnas.1222694110