Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology

Michael Bertoldo 1, 2 Edith Guibert 1 Melanie Faure 1 Christelle Ramé 1 Marc Foretz 3 Benoit Viollet 3 Joëlle Dupont 1 Pascal Froment 1, *
* Corresponding author
1 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
2 Discipline of Obstetrics and Gynaecology
3 IC UM3 (UMR 8104 / U1016) - Institut Cochin
Abstract : Oogenesis and folliculogenesis are dynamic processes that are regulated by endocrine, paracrine and autocrine signals. These signals are exchanged between the oocyte and the somatic cells of the follicle. Here we analyzed the role of AMP-activated protein kinase (AMPK), an important regulator of cellular energy homeostasis, by using transgenic mice deficient in α1AMPK specifically in the oocyte. We found a decrease of 27% in litter size was observed in ZP3-α1AMPK-/-(ZP3-KO) female mice. Following in vitro fertilization,
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Submitted on : Friday, March 27, 2015 - 3:49:15 PM
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Michael Bertoldo, Edith Guibert, Melanie Faure, Christelle Ramé, Marc Foretz, et al.. Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology. PLoS ONE, Public Library of Science, 2015, 10 (3), pp.e0119680. ⟨10.1371/journal.pone.0119680⟩. ⟨inserm-01136604⟩

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