Diffusion MRI abnormalities detection with orientation distribution functions: A multiple sclerosis longitudinal study

Olivier Commowick; Adil Maarouf; Jean-Christophe Ferré; Jean-Philippe Ranjeva; Gilles Edan; Christian Barillot

doi:10.1016/j.media.2015.02.005

Diffusion MRI abnormalities detection with orientation distribution functions: A multiple sclerosis longitudinal study

Olivier Commowick ¹ Adil Maarouf ² Jean-Christophe Ferré ^{1, 3} Jean-Philippe Ranjeva ⁴ Gilles Edan ^{5, 3} Christian Barillot ¹

1 VisAGeS - Vision, Action et Gestion d'informations en Santé

INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE

2 Service de neurologie [Reims]

3 Service de radiologie et imagerie médicale [Rennes]

4 CRMBM - Centre de résonance magnétique biologique et médicale

5 CIC - Centre d'Investigation Clinique [Rennes]

Abstract : We propose a new algorithm for the voxelwise analysis of orientation distribution functions between one image and a group of reference images. It relies on a generic framework for the comparison of diffusion probabilities on the sphere, sampled from the underlying models. We demonstrate that this method, combined to dimensionality reduction through a principal component analysis, allows for more robust detection of lesions on simulated data when compared to classical tensor-based analysis. We then demonstrate the efficiency of this pipeline on the longitudinal comparison of multiple sclerosis patients at an early stage of the disease: right after their first clinically isolated syndrome (CIS) and three months later. We demonstrate the pre-dictive value of ODF-based scores for the early detection of lesions that will appear or heal.

Keywords : patient to controls comparison Orientation distribution functions Diffusion MRI

Type de document :

Article dans une revue

Medical Image Analysis, Elsevier, 2015, 22 (1), pp.114-123. 〈10.1016/j.media.2015.02.005〉

Domaine :

Sciences du Vivant [q-bio] / Neurosciences [q-bio.NC]

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https://www.hal.inserm.fr/inserm-01134107
Contributeur : Olivier Commowick <>
Soumis le : dimanche 22 mars 2015 - 17:04:29
Dernière modification le : vendredi 16 novembre 2018 - 01:39:10
Document(s) archivé(s) le : lundi 17 avril 2017 - 20:44:17

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