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In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation

Abstract : The CD28 costimulatory receptor has a pivotal role in T cell biology as this molecule amplifies T cell receptor (TCR) signals to provide an efficient immune T cell response. There is a large debate about how CD28 mediates these signals. Here, we designed a CD28 gene targeted knock-in mouse strain lacking the cytoplasmic tail of CD28. As is the case in CD28-deficient (CD28 knockout) mice, regulatory T cell homeostasis and T cell activation are altered in these CD28 knock-in mice. Unexpectedly, the presence of a CD28 molecule deprived of its cytoplasmic tail could partially induce some early activation events in T cells such as signaling events or expression of early activation markers. These results unravel a new mechanism of T cell costimulation by CD28, independent of its cytoplasmic tail.
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https://www.hal.inserm.fr/inserm-01122788
Contributor : Jacques Nunès <>
Submitted on : Wednesday, March 4, 2015 - 3:21:42 PM
Last modification on : Monday, February 17, 2020 - 9:34:01 AM
Long-term archiving on: : Friday, June 5, 2015 - 11:01:02 AM

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Digital Object Identifier (DOI) 10.1007/s00018-015-1873-7 The final publication is available at link.springer.com .

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Stéphanie Morin, Valentin Giroux, Cédric Favre, Yassina Bechah, Nathalie Auphan-Anezin, et al.. In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation. Cellular and Molecular Life Sciences, Springer Verlag, 2015, pp.DOI 10.1007/s00018-015-1873-7. ⟨10.1007/s00018-015-1873-7⟩. ⟨inserm-01122788⟩

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