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Journal articles
In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation
Abstract : The CD28 costimulatory receptor has a pivotal role in T cell biology as this molecule amplifies T cell receptor (TCR) signals to provide an efficient immune T cell response. There is a large debate about how CD28 mediates these signals. Here, we designed a CD28 gene targeted knock-in mouse strain lacking the cytoplasmic tail of CD28. As is the case in CD28-deficient (CD28 knockout) mice, regulatory T cell homeostasis and T cell activation are altered in these CD28 knock-in mice. Unexpectedly, the presence of a CD28 molecule deprived of its cytoplasmic tail could partially induce some early activation events in T cells such as signaling events or expression of early activation markers. These results unravel a new mechanism of T cell costimulation by CD28, independent of its cytoplasmic tail.
Cited literature [18 references]
https://www.hal.inserm.fr/inserm-01122788
Contributor : Jacques Nunès <>
Submitted on : Wednesday, March 4, 2015 - 3:21:42 PM
Last modification on : Friday, December 11, 2020 - 2:04:02 PM
Long-term archiving on: : Friday, June 5, 2015 - 11:01:02 AM
Contributor : Jacques Nunès <>
Submitted on : Wednesday, March 4, 2015 - 3:21:42 PM
Last modification on : Friday, December 11, 2020 - 2:04:02 PM
Long-term archiving on: : Friday, June 5, 2015 - 11:01:02 AM
File
CMLS-D-14-00229.pdf
Files produced by the author(s)
Digital Object Identifier (DOI) 10.1007/s00018-015-1873-7
The final publication is available at link.springer.com .