In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation

Stéphanie Morin 1 Valentin Giroux 1 Cédric Favre 1 Yassina Bechah 2 Nathalie Auphan-Anezin 3 Romain Roncagalli 3 Jean-Louis Mège 2 Daniel Olive 1 Marie Malissen 3 Jacques Nunes 1, *
* Auteur correspondant
1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
3 CIML - Centre d'Immunologie de Marseille - Luminy
Abstract : The CD28 costimulatory receptor has a pivotal role in T cell biology as this molecule amplifies T cell receptor (TCR) signals to provide an efficient immune T cell response. There is a large debate about how CD28 mediates these signals. Here, we designed a CD28 gene targeted knock-in mouse strain lacking the cytoplasmic tail of CD28. As is the case in CD28-deficient (CD28 knockout) mice, regulatory T cell homeostasis and T cell activation are altered in these CD28 knock-in mice. Unexpectedly, the presence of a CD28 molecule deprived of its cytoplasmic tail could partially induce some early activation events in T cells such as signaling events or expression of early activation markers. These results unravel a new mechanism of T cell costimulation by CD28, independent of its cytoplasmic tail.
Keywords : T cells CD28 Immune response Costimulatory molecules
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Article dans une revue
Cellular and Molecular Life Sciences, Springer Verlag, 2015, pp.DOI 10.1007/s00018-015-1873-7. 〈10.1007/s00018-015-1873-7 〉
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Digital Object Identifier (DOI) 10.1007/s00018-015-1873-7 The final publication is available at link.springer.com .

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Stéphanie Morin, Valentin Giroux, Cédric Favre, Yassina Bechah, Nathalie Auphan-Anezin, et al.. In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation. Cellular and Molecular Life Sciences, Springer Verlag, 2015, pp.DOI 10.1007/s00018-015-1873-7. 〈10.1007/s00018-015-1873-7 〉. 〈inserm-01122788〉

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