Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial

Gisèle Pickering 1, 2, 3, * Véronique Morel 1, 2, 3 Dominique Joly 4 Christine Villatte 4 Delphine Roux 2 Claude Dubray 1, 2, 3 Bruno Pereira 5
* Auteur correspondant
3 Pharmacologie fondamentale et clinique de la douleur
Neuro-Dol - Neuro-Dol, UdA - Université d'Auvergne - Clermont-Ferrand I, INSERM - Institut National de la Santé et de la Recherche Médicale : U766
Abstract : Background: N-methyl-D-aspartate receptor antagonists are potential therapies for neuropathic pain, and memantine has a good tolerance profile. A preclinical study recently reported that presurgery memantine may prevent neuropathic pain development and cognition dysfunction. Considering the high prevalence of breast cancer and of post-mastectomy neuropathic pain, a clinical trial is carried out to evaluate if memantine may prevent neuropathic pain development and maintain cognitive function and quality of life in cancer patients. Methods/Design: A randomized clinical trial (NCT01536314) includes 40 women with breast cancer undergoing mastectomy at the Oncology Hospital, Clermont-Ferrand, France. Memantine (5 to 20 mg/day; n = 20) or placebo (n = 20) is administered for 4 weeks starting 2 weeks before surgery. Intensity of pain, cognitive function, quality of life and of sleep, anxiety and depression are evaluated with questionnaires. The primary endpoint is pain intensity on a 0 to 10) numerical scale at 3 months post-mastectomy. Data analysis is performed using mixed models and the tests are two-sided, with a type I error set at α = 0.05. Discussion: The hypothesis of this translational approach is to confirm in patients the beneficial prophylactic effect of memantine observed in animals. Such a protective action of memantine against neuropathic pain and cognitive dysfunction would greatly improve the quality of life of cancer patients. Trial registration: ClinicalTrials.gov: NCT01536314 on 16 February 2012
Type de document :
Article dans une revue
Trials, BioMed Central, 2014, 15, pp.331. 〈10.1186/1745-6215-15-331〉
Liste complète des métadonnées

Littérature citée [45 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01122386
Contributeur : Christine Dupuis <>
Soumis le : mardi 3 mars 2015 - 17:15:08
Dernière modification le : mardi 19 décembre 2017 - 09:42:09
Document(s) archivé(s) le : samedi 12 septembre 2015 - 23:00:35

Fichier

1745-6215-15-331.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Gisèle Pickering, Véronique Morel, Dominique Joly, Christine Villatte, Delphine Roux, et al.. Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial. Trials, BioMed Central, 2014, 15, pp.331. 〈10.1186/1745-6215-15-331〉. 〈inserm-01122386〉

Partager

Métriques

Consultations de la notice

274

Téléchargements de fichiers

257