Alteration of CD1 expression in multiple sclerosis

Sébastien Bine 1, 2 Alain Haziot 1, 2 I Malikova 3 J Pelletier 3 Dominique Charron 1, 2 José Boucraut 3 Nuala Mooney 1, 2 Catherine Gelin 1, 2
1 Hôpital d'Instruction des Armées du Val de Grâce
2 Hématologie -Immunologie -Cibles thérapeutiques
3 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille
Abstract : Studies of multiple sclerosis (MS) have concentrated mainly on antigen pre-sentation of peptides derived from the myelin sheath, while the implication of lipid antigen has been less explored in this pathology. As the extracellular environment regulates expression of the lipid antigen-presenting molecule CD1, we have examined whether sera from patients alters CD1 surface expres-sion in monocyte-derived dendritic cells. We have shown that: (i) CD1 group 1 proteins were highly expressed in the presence of MS sera; (ii) sera from MS patients differentially regulated CD1 group 1 versus CD1 group 2 molecular expression; and (iii) CD1 was expressed strongly in monocytes from MS patients under immunosuppressive treatment. Overall, these results reveal that CD1 expression is modified in MS and provide novel information on the regulation of lipid antigen presentation in myeloid cells.
Keywords : dendritic cells autoimmunity serum multiple sclerosis monocytes
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Article dans une revue
Clinical and Experimental Immunology, Wiley, 2012, 169 (1), pp.10-16. 〈10.1111/j.1365-2249.2012.04586.x〉
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Dernière modification le : lundi 29 janvier 2018 - 17:28:17
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Sébastien Bine, Alain Haziot, I Malikova, J Pelletier, Dominique Charron, et al.. Alteration of CD1 expression in multiple sclerosis. Clinical and Experimental Immunology, Wiley, 2012, 169 (1), pp.10-16. 〈10.1111/j.1365-2249.2012.04586.x〉. 〈inserm-01119453〉

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