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P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.

Shulong J Hu 1 Bertrand Calippe 1 Sophie Lavalette 1 Christophe Roubeix 1 Fadoua Montassar 1 Michael Housset 1 Olivier Levy 1 Cecile Delarasse 2 Michel Paques 1 José-Alain Sahel 1 Florian Sennlaub 1 Xavier Guillonneau 1
1 Institut de la Vision
2 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
Abstract : To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal detachment, where subretinal C57BL/6J-MPs have been shown to participate in photoreceptor degeneration (Nakazawa et al., 2007). C57BL/6J and P2rx7-/- mice exhibit similar subretinal MP accumulation but showed no difference in the number of TUNEL positive photoreceptor cells under these conditions.
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Preprints, Working Papers, ...
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https://www.hal.inserm.fr/inserm-01113110
Contributor : Xavier Guillonneau Connect in order to contact the contributor
Submitted on : Wednesday, February 4, 2015 - 2:16:37 PM
Last modification on : Monday, November 23, 2020 - 11:46:11 AM

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Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

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  • HAL Id : inserm-01113110, version 1

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INSERM | UPMC | CNRS | U968 | ICM | SORBONNE-UNIVERSITE | SU-MEDECINE

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Shulong J Hu, Bertrand Calippe, Sophie Lavalette, Christophe Roubeix, Fadoua Montassar, et al.. P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.. 2015. ⟨inserm-01113110⟩

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