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P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.

Abstract : To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal detachment, where subretinal C57BL/6J-MPs have been shown to participate in photoreceptor degeneration (Nakazawa et al., 2007). C57BL/6J and P2rx7-/- mice exhibit similar subretinal MP accumulation but showed no difference in the number of TUNEL positive photoreceptor cells under these conditions.
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Preprints, Working Papers, ...
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https://www.hal.inserm.fr/inserm-01113110
Contributor : Xavier Guillonneau <>
Submitted on : Wednesday, February 4, 2015 - 2:16:37 PM
Last modification on : Thursday, March 21, 2019 - 12:24:22 PM

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  • HAL Id : inserm-01113110, version 1

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Shulong J Hu, Bertrand Calippe, Sophie Lavalette, Christophe Roubeix, Fadoua Montassar, et al.. P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.. 2015. ⟨inserm-01113110⟩

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