Abstract : To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal detachment, where subretinal C57BL/6J-MPs have been shown to participate in photoreceptor degeneration (Nakazawa et al., 2007). C57BL/6J and P2rx7-/- mice exhibit similar subretinal MP accumulation but showed no difference in the number of TUNEL positive photoreceptor cells under these conditions.
http://www.hal.inserm.fr/inserm-01113110
Contributeur : Xavier Guillonneau
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Soumis le : mercredi 4 février 2015 - 14:16:37
Dernière modification le : vendredi 31 août 2018 - 09:13:20
Shulong J Hu, Bertrand Calippe, Sophie Lavalette, Christophe Roubeix, Fadoua Montassar, et al.. P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.. Referenced in J Neurosci as URL. 2015. 〈inserm-01113110〉
