 |
Journal articles
O-GlcNAcylation links ChREBP and FXR to glucose-sensing
Abstract : Accumulating evidence suggests that O-GlcNAc transferase, an enzyme responsible for O-GlcNAc post-translational modification acts as a nutrient sensor that links glucose and the hexosamine biosynthetic pathway to the regulation of transcriptional factors involved in energy homeostasis. In liver, glucose signaling is mediated by carbohydrate response element-binding protein (ChREBP), which stimulates glycolytic and lipogenic gene expres-sion through its binding on a specific ChoRE DNA sequence. Modulation of ChREBP by O-GlcNAcylation increases its DNA binding affinity and its activity. ChREBP transcriptional activity also depends on the presence of several other co-factors and transcriptional fac-tors. Among them, the nuclear Farnesoid X Receptor (FXR), a key transcription factor of bile acid metabolism involved in the gut–liver axis homeostasis was recently shown to directly interact with ChREBP, acting as a repressor on the ChoRE of glycolytic genes. Interestingly, similarly to ChREBP, FXR is O-GlcNAcylated in response to glucose. This review discusses the importance of ChREBP and FXR modifications through O-GlcNAcylation in liver and how glucose can modify their mutual affinity and transcriptional activity.
Cited literature [40 references]
https://www.hal.inserm.fr/inserm-01103380
Contributor : Mireille Bos Connect in order to contact the contributor
Submitted on : Wednesday, January 14, 2015 - 3:49:44 PM
Last modification on : Wednesday, October 27, 2021 - 2:11:56 PM
Long-term archiving on: : Friday, September 11, 2015 - 6:47:02 AM
Contributor : Mireille Bos Connect in order to contact the contributor
Submitted on : Wednesday, January 14, 2015 - 3:49:44 PM
Last modification on : Wednesday, October 27, 2021 - 2:11:56 PM
Long-term archiving on: : Friday, September 11, 2015 - 6:47:02 AM
File
fendo-05-00230.pdf
Publisher files allowed on an open archive
Licence
Distributed under a Creative Commons Attribution 4.0 International License