Register-based incidence of multiple sclerosis in Brittany (north-western France), 2000-2001.

Abstract : Objectives – To report on multiple sclerosis (MS) incidence in Brittany, north-western France. Materials & Methods – From 2000, we set up a population-based register for patients presenting a putative incident MS (PIMS), that is first symptoms compatible with MS onset. We used 3 medical sources of case ascertainment (neurologists, CSF, regional MS-Clinic). Eligibility criteria required both clinical onset and being permanent resident of Brittany in 2000 or 2001. From 2010, all medical records were tracked, the 10-year follow-up allowing previously reported data to be updated. Results – Of 313 eligible PIMS, there were 208 definite MS (both McDonald and Poser criteria), 41 CIS-probable MS (Poser criteria), 32 CIS-possible MS and 32 non-MS. Our incident cohort of 249 MS cases with definite/ probable MS (sex ratio 2.95) gave a crude annual incidence of 4.28 per 100,000 inhabitants (6.22 for women, 2.23 for men), and age-standardized rates (adjustment to the European population) of 4.41 [3.32–5.51], 6.68 [4.75–8.60], and 2.21 [1.12–3.31], respectively. Age-specific rates by gender and initial course showed that attack onset MS peaked at 25–29 years and progressive onset MS at 40–44 years in women (20–24 years and 45–49 years in men, respectively). Conclusions – Brittany is confirmed a high-risk region for MS. Our data show marked differences in sex-specific pattern of MS incidence by clinical course and point out 25-to 29-year-old women as having the highest MS risk. While temporal variations cannot be excluded, comparison with overall French data suggests that other factors rather than latitude may influence the MS risk in France.
Document type :
Journal articles
Complete list of metadatas

Cited literature [18 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01103109
Contributor : Gilles Edan <>
Submitted on : Wednesday, January 14, 2015 - 9:51:49 AM
Last modification on : Monday, March 4, 2019 - 2:08:15 PM
Long-term archiving on : Friday, September 11, 2015 - 6:43:20 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Jacqueline Yaouanq, Isabelle Tron, Anne Kerbrat, Emmanuelle Leray, S Hamonic, et al.. Register-based incidence of multiple sclerosis in Brittany (north-western France), 2000-2001.. Acta Neurologica Scandinavica Supplementum, Wiley-Blackwell, 2014, 131 (5), pp.321-328. ⟨10.1111/ane.12332⟩. ⟨inserm-01103109⟩

Share

Metrics

Record views

422