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Elderly Benzodiazepine Users at Increased Risk of Activity Limitations: Influence of Chronicity, Indications, and Duration of Action-The Three-City Cohort.

Abstract : Objective: To examine the cross-sectional and longitudinal associations between benzodiazepine use and daily activity limitations, according to drug indications and duration of action.Design: Prospective cohort study.Setting: Population-based 3-city studyParticipants: 6 600 participants aged 65 years and over included between 1999 and 2001 and followed after 2, 4 and 7 years. Measurements: Benzodiazepine users were separated into hypnotic, short-acting anxiolytic and long-acting anxiolytic users and compared with non users. Three outcomes were examined assessing restrictions in mobility, instrumental activities of daily living (IADL) and social participation. Results: In multivariate simple or mixed logistic models adjusted for socio-demographic variables, impairments and comorbidity and for anxiety, insomnia and depression, hypnotic benzodiazepines were moderately associated with mobility limitation prevalence and IADL limitation incidence. Short-acting and long-acting anxiolytics were associated with IADL limitation prevalence and with mobility limitation prevalence and incidence and long-acting anxiolytics were also associated with IADL limitations incidence. Chronic benzodiazepines users were at a marked risk of developing restrictions for the three outcomes (odds ratio 1.71 (95% confidence interval (CI), 1.23-2.39) for mobility, 1.54 [95%CI, 1.14-2.10] for IADL and 1.74 [95%CI, 1.23-2.47] for participation limitations).Conclusions: Benzodiazepine users are at increased risk of activity limitations regardless of the duration of action or indication. Chronic use of benzodiazepines should be avoided in order to extend disability-free survival.
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https://www.hal.inserm.fr/inserm-01100997
Contributor : Isabelle Carrière <>
Submitted on : Wednesday, January 7, 2015 - 3:26:55 PM
Last modification on : Wednesday, July 15, 2020 - 11:54:01 AM
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Isabelle Carrière, Thibault Mura, Karine Pérès, Joanna Norton, Isabelle Jaussent, et al.. Elderly Benzodiazepine Users at Increased Risk of Activity Limitations: Influence of Chronicity, Indications, and Duration of Action-The Three-City Cohort.. American Journal of Geriatric Psychiatry, Elsevier, 2014, pp.1545-7214. ⟨10.1016/j.jagp.2014.10.006⟩. ⟨inserm-01100997⟩

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