Skip to Main content Skip to Navigation
Journal articles

Prevalence and risk factors of vitamin D deficiency in inherited ichthyosis: a French prospective observational study performed in a reference center.

Abstract : Background:To date, few studies have investigated serum vitamin D status in patients with inherited ichthyosis.The aim of this study was to determine the prevalence of vitamin D deficiency (defined as serum level <10 ng/mL)in a French cohort of patients and to identify associated risk factors.Methods:This was a prospective observational study performed in a hospital reference center with expertise forrare skin diseases. Patients’clinical characteristics were recorded. Serum concentration of 25-hydroxyvitamin D andparathyroid hormone were determined. For patients with vitamin D deficiency, serum calcium, serum phosphorusand bone mineral density were also investigated. Comparisons between groups (25-hydroxyvitamin D <10 ng/mLversus≥10 ng/mL) were conducted by univariate and multivariate logistic regression.Results:Of the 53 included patients, 47 (88.7%) had serum 25-hydroxyvitamin D below the optimal level of 30 ng/mL:18 (34%) had vitamin D sufficiency, 14 (26.4%) had vitamin D insufficiency, and 15 (28.3%) had vitamin D deficiency. Anegative linear correlation was found between 25-hydroxyvitamin D and parathyroid hormone levels for the wholestudy population. Serum calcium and phosphorus levels were normal for the 15 patients with vitamin D deficiency.Bone mineral density was investigated for 11 of these latter 15 patients, and six of them had osteopenia. Winter/springseasons of vitamin D measurement, severity of ichthyosis, and phototypes IV–VI were identified as independent riskfactors for vitamin D deficiency.Conclusions:Clinicians should be aware of the risk of vitamin D deficiency in the management of patients withinherited ichthyosis, especially in winter and spring, and in case of dark skin or severe disease.
Document type :
Journal articles
Complete list of metadatas

Cited literature [35 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01091584
Contributor : Nadia Taibi <>
Submitted on : Friday, December 5, 2014 - 4:31:45 PM
Last modification on : Sunday, October 25, 2020 - 7:07:52 AM
Long-term archiving on: : Monday, March 9, 2015 - 6:04:51 AM

File

s13023-014-0127-3.pdf
Publisher files allowed on an open archive

Identifiers

  • HAL Id : inserm-01091584, version 1
  • PUBMED : 25091406

Citation

Flora Frascari, Isabelle Dreyfus, Lauriane Rodriguez, Isabelle Gennero, Khaled Ezzedine, et al.. Prevalence and risk factors of vitamin D deficiency in inherited ichthyosis: a French prospective observational study performed in a reference center.. Orphanet Journal of Rare Diseases, BioMed Central, 2013, pp.127. ⟨inserm-01091584⟩

Share

Metrics

Record views

382

Files downloads

382