Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease

Nathalie Lemonne; Yann Lamarre; Marc Romana; Marie-Dominique Hardy-Dessources; François Lionnet; Xavier Waltz; Vanessa Tarer; Danielle Mougenel; Benoît Tressières; Marie-Laure Lalanne-Mistrih; Maryse Etienne-Julan; Philippe Connes; Philippe Connes

Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease: Blood viscosity in hemoglobin SC disease

Nathalie Lemonne ¹ Yann Lamarre ^{2, 3} Marc Romana ² Marie-Dominique Hardy-Dessources ^{2, 3} François Lionnet ⁴ Xavier Waltz ⁵ Vanessa Tarer ⁶ Danielle Mougenel ¹ Benoît Tressières ⁷ Marie-Laure Lalanne-Mistrih ⁷ Maryse Etienne-Julan ^{2, 1, 6} Philippe Connes ^{5, 8, *} Philippe Connes ^{5, 8}

* Corresponding author

1 Unité Transversale de la Drépanocytose

2 Protéines de la membrane érythrocytaire et homologues non-érythroides

3 Laboratory of Excellence GR-Ex "The red cell: from genesis to death"

4 Centre de référence des syndromes drépanocytaires majeurs

5 ACTES - Adaptations au Climat Tropical, Exercice et Santé

6 Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane

7 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane

8 IUF - Institut Universitaire de France

Abstract : Lionnet et al. recently reported a high prevalence of retinopathy (RET) and otologic disorders (OTD) in patients with sickle cell-hemoglobin C disease (SC), while a significant number of patients had renal diseases (mainly glomerulopathy; GLO) and osteonecrosis (OST). The pathophysiological processes of these complications in SC are not well defined, although blood hyperviscosity has been suspected, but never tested to the best of our knowledge, as responsible for several chronic complications in SC disease1,2. The aim of this study was to analyze the associations between hematological and hemorheological parameters and chronic complications in adult SC patients.

Keywords : Sickle cell disease sickle cell-hemoglobin C disease blood viscosity otologic disorders retinopathy

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Journal articles

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Life Sciences [q-bio] / Santé publique et épidémiologie

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2014, Lemonne - Impaired blood...

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Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease: Blood viscosity in hemoglobin SC disease

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Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease: Blood viscosity in hemoglobin SC disease

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