N. White, S. Pukrittayakamee, T. Hien, M. Faiz, and O. Mokuolu, Malaria. Lancet: published online Aug 15, Available, pp.140-673660024, 1013.
URL : https://hal.archives-ouvertes.fr/inserm-00730637

N. White, G. Turner, N. Day, and A. Dondorp, Lethal Malaria: Marchiafava and Bignami Were Right, Journal of Infectious Diseases, vol.208, issue.2, pp.192-198, 2013.
DOI : 10.1093/infdis/jit116

A. Craig and A. Scherf, Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion, Molecular and Biochemical Parasitology, vol.115, issue.2, pp.129-143, 2001.
DOI : 10.1016/S0166-6851(01)00275-4

E. Marchiafava and A. Bignami, On summer-autumn malarial fevers, Two monographs on malaria and the parasites of malarial fevers), 1894.

J. Montgomery, F. Mphande, M. Berriman, A. Pain, and S. Rogerson, Differential var gene expression in the organs of patients dying of falciparum malaria, Molecular Microbiology, vol.8, issue.4, pp.959-967, 2007.
DOI : 10.1016/j.molbiopara.2006.03.012

G. Macpherson, M. Warrell, N. White, S. Looareesuwan, and D. Warrell, Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration, Am J Pathol, vol.119, pp.385-401, 1985.

K. Silamut, N. Phu, C. Whitty, G. Turner, and K. Louwrier, A Quantitative Analysis of the Microvascular Sequestration of Malaria Parasites in the Human Brain, The American Journal of Pathology, vol.155, issue.2, pp.395-410, 1999.
DOI : 10.1016/S0002-9440(10)65136-X

M. Avril, A. Tripathi, A. Brazier, C. Andisi, and J. Janes, A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells, Proceedings of the National Academy of Sciences, vol.109, issue.26, pp.1782-1790, 2012.
DOI : 10.1073/pnas.1120534109

A. Claessens, Y. Adams, A. Ghumra, G. Lindergard, and C. Buchan, A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells, Proceedings of the National Academy of Sciences, vol.109, issue.26, pp.1772-1781, 2012.
DOI : 10.1073/pnas.1120461109

T. Lavstsen, L. Turner, F. Saguti, P. Magistrado, and T. Rask, Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children, Proceedings of the National Academy of Sciences, vol.109, issue.26, pp.1791-1800, 2012.
DOI : 10.1073/pnas.1120455109

I. Clark and K. Rockett, The cytokine theory of human cerebral malaria, Parasitology Today, vol.10, issue.10, pp.410-412, 1994.
DOI : 10.1016/0169-4758(94)90237-2

G. Grau and S. De-kossodo, Cerebral malaria: Mediators, mechanical obstruction or more?, Parasitology Today, vol.10, issue.10, pp.408-409, 1994.
DOI : 10.1016/0169-4758(94)90236-4

A. Dondorp, C. Ince, P. Charunwatthana, J. Hanson, and A. Van-kuijen, Direct In Vivo Assessment of Microcirculatory Dysfunction in Severe Falciparum Malaria, The Journal of Infectious Diseases, vol.197, issue.1, pp.79-84, 2008.
DOI : 10.1086/523762

R. Idro, N. Jenkins, and C. Newton, Pathogenesis, clinical features, and neurological outcome of cerebral malaria, The Lancet Neurology, vol.4, issue.12, pp.827-840, 2005.
DOI : 10.1016/S1474-4422(05)70247-7

L. Miller, D. Baruch, K. Marsh, and O. Doumbo, The pathogenic basis of malaria, Nature, vol.415, issue.6872, pp.673-679, 2002.
DOI : 10.1038/415673a

M. Gillrie, K. Lee, D. Gowda, S. Davis, and M. Monestier, Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction, The American Journal of Pathology, vol.180, issue.3, pp.1028-1039, 2012.
DOI : 10.1016/j.ajpath.2011.11.037

URL : http://doi.org/10.1016/j.ajpath.2011.11.037

G. Krishnegowda, A. Hajjar, J. Zhu, E. Douglass, and S. Uematsu, Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum: CELL SIGNALING RECEPTORS, GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) STRUCTURAL REQUIREMENT, AND REGULATION OF GPI ACTIVITY, Journal of Biological Chemistry, vol.280, issue.9, pp.8606-8616, 2005.
DOI : 10.1074/jbc.M413541200

M. Prato, D. 'alessandro, S. Van-den-steen, P. Opdenakker, G. Arese et al., Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium, Cellular Microbiology, vol.114, issue.48, pp.1275-1285, 2011.
DOI : 10.1111/j.1462-5822.2011.01620.x

L. Schofield and G. Grau, Immunological processes in malaria pathogenesis, Nature Reviews Immunology, vol.87, issue.9, pp.722-735, 2005.
DOI : 10.1128/CMR.14.4.810-820.2001

G. Turner, H. Morrison, M. Jones, T. Davis, and S. Looareesuwan, An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration, Am J Pathol, vol.145, pp.1057-1069, 1994.

C. Hemmer, P. Kern, F. Holst, K. Radtke, and R. Egbring, Activation of the host response in human plasmodium falciparum malaria: Relation of parasitemia to tumor necrosis factor/cachectin, thrombin-antithrombin III, and protein C levels, The American Journal of Medicine, vol.91, issue.1, pp.37-44, 1991.
DOI : 10.1016/0002-9343(91)90071-5

P. Gerardin, C. Rogier, A. Ka, P. Jouvencel, and V. Brousse, Prognostic value of thrombocytopenia in African children with falciparum malaria, Am J Trop Med Hyg, vol.66, pp.686-691, 2002.

V. Combes, T. Taylor, I. Juhan-vague, J. Mege, and J. Mwenechanya, Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma, JAMA, vol.291, pp.2542-2544, 2004.

I. Medana and G. Turner, Human cerebral malaria and the blood???brain barrier, International Journal for Parasitology, vol.36, issue.5, pp.555-568, 2006.
DOI : 10.1016/j.ijpara.2006.02.004

W. Taylor, J. Hanson, G. Turner, N. White, and A. Dondorp, Respiratory Manifestations of Malaria, Chest, vol.142, issue.2, pp.492-505, 2012.
DOI : 10.1378/chest.11-2655

Z. Taoufiq, F. Gay, J. Balvanyos, L. Ciceron, and M. Tefit, Rho Kinase Inhibition in Severe Malaria: Thwarting Parasite???Induced Collateral Damage to Endothelia, The Journal of Infectious Diseases, vol.197, issue.7, pp.1062-1073, 2008.
DOI : 10.1086/528988

Z. Taoufiq, P. Pino, N. Dilimabaka, N. Arrouss, I. Assi et al., Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage, Malaria Journal, vol.10, issue.1, p.52, 2011.
DOI : 10.1016/j.exppara.2010.01.005

URL : https://hal.archives-ouvertes.fr/inserm-00663669

R. Jambou, V. Combes, M. Jambou, B. Weksler, and P. Couraud, Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions, PLoS Pathogens, vol.19, issue.7, p.1001021, 2010.
DOI : 10.1371/journal.ppat.1001021.g009

URL : https://hal.archives-ouvertes.fr/pasteur-00837812

S. Zougbede, F. Miller, P. Ravassard, A. Rebollo, and L. Ciceron, Intraerythrocytic Stages Alters Blood???Brain Barrier Integrity, Journal of Cerebral Blood Flow & Metabolism, vol.101, issue.2, pp.514-526, 2011.
DOI : 10.1016/j.ijpara.2006.02.004

A. Tripathi, D. Sullivan, and M. Stins, ???Infected Erythrocytes Decrease the Integrity of Human Blood???Brain Barrier Endothelial Cell Monolayers, The Journal of Infectious Diseases, vol.195, issue.7, pp.942-950, 2007.
DOI : 10.1086/512083

M. Gillrie, G. Krishnegowda, K. Lee, A. Buret, and S. Robbins, Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins, Blood, vol.110, issue.9, pp.3426-3435, 2007.
DOI : 10.1182/blood-2007-04-084582

N. Mita-mendoza, D. Van-de-hoef, T. Lopera-mesa, S. Doumbia, and D. Konate, A Potential Role for Plasma Uric Acid in the Endothelial Pathology of Plasmodium falciparum malaria, PLoS ONE, vol.52, issue.2, p.54481, 2013.
DOI : 10.1371/journal.pone.0054481.t003

C. Hemmer, H. Lehr, K. Westphal, M. Unverricht, and M. Kratzius, Plasmodium falciparum Malaria: Reduction of Endothelial Cell Apoptosis In Vitro, Infection and Immunity, vol.73, issue.3, pp.1764-1770, 2005.
DOI : 10.1128/IAI.73.3.1764-1770.2005

P. Pino, I. Vouldoukis, N. Dugas, G. Hassani-loppion, and B. Dugas, -Infected Erythrocytes, Annals of the New York Academy of Sciences, vol.12, issue.1, pp.582-586, 2003.
DOI : 10.1196/annals.1299.109

URL : https://hal.archives-ouvertes.fr/hal-01009683

A. Tripathi, W. Sha, V. Shulaev, M. Stins, D. Sullivan et al., Plasmodium falciparum-infected erythrocytes induce NF-??B regulated inflammatory pathways in human cerebral endothelium, Blood, vol.114, issue.19, pp.4243-4252, 2009.
DOI : 10.1182/blood-2009-06-226415

S. Wassmer, V. Combes, F. Candal, I. Juhan-vague, and G. Grau, Platelets Potentiate Brain Endothelial Alterations Induced by Plasmodium falciparum, Infection and Immunity, vol.74, issue.1, pp.645-653, 2006.
DOI : 10.1128/IAI.74.1.645-653.2006

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346683

F. Toure, O. Ouwe-missi-oukem-boyer, U. Bisvigou, O. Moussa, and C. Rogier, Apoptosis: a potential triggering mechanism of neurological manifestation in Plasmodium falciparum malaria, Parasite Immunology, vol.168, issue.0, pp.47-51, 2008.
DOI : 10.1086/322012

E. Zang-edou, U. Bisvigou, Z. Taoufiq, F. Lekoulou, and J. Lekana-douki, Inhibition of Plasmodium falciparum Field Isolates-Mediated Endothelial Cell Apoptosis by Fasudil: Therapeutic Implications for Severe Malaria, PLoS ONE, vol.5, issue.2, p.13221, 2010.
DOI : 10.1371/journal.pone.0013221.t002

A. Siau, F. Toure, O. Ouwe-missi-oukem-boyer, L. Ciceron, and N. Mahmoudi, Field Isolates: Identification of New Pathogenicity Factors, The Journal of Infectious Diseases, vol.196, issue.11, pp.1603-1612, 2007.
DOI : 10.1086/522012

C. Punsawad, Y. Maneerat, U. Chaisri, K. Nantavisai, and P. Viriyavejakul, Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria, Malaria Journal, vol.12, issue.1, p.260, 2013.
DOI : 10.1186/1475-2875-12-260

K. Muanza, F. Gay, C. Behr, and A. Scherf, Primary culture of human lung microvessel endothelial cells : A useful in vitro model for studying Plasmodium falciparum-infected erythrocyte cytoadherence, Research in Immunology, vol.147, issue.3, pp.149-163, 1996.
DOI : 10.1016/0923-2494(96)83167-1

B. Weksler, I. Romero, and P. Couraud, The hCMEC/D3 cell line as a model of the human blood brain barrier, Fluids and Barriers of the CNS, vol.10, issue.1, p.16, 2013.
DOI : 10.1038/nbt.2247

URL : https://hal.archives-ouvertes.fr/inserm-00812147

B. Weksler, E. Subileau, N. Perriere, P. Charneau, and K. Holloway, Blood-brain barrier-specific properties of a human adult brain endothelial cell line, The FASEB Journal, vol.19, pp.1872-1874, 2005.
DOI : 10.1096/fj.04-3458fje

I. Goodyer, J. Johnson, R. Eisenthal, and D. Hayes, by gelatine flotation, Annals of Tropical Medicine & Parasitology, vol.27, issue.2, pp.209-211, 1994.
DOI : 10.1080/00034983.1978.11719283

J. Gardner, R. Pinches, D. Roberts, and C. Newbold, Variant antigens and endothelial receptor adhesion in Plasmodium falciparum., Proceedings of the National Academy of Sciences, vol.93, issue.8, pp.3503-3508, 1996.
DOI : 10.1073/pnas.93.8.3503

N. Day, N. Phu, N. Mai, T. Chau, and P. Loc, The pathophysiologic and prognostic significance of acidosis in severe adult malaria, Critical Care Medicine, vol.28, issue.6, pp.1833-1840, 2000.
DOI : 10.1097/00003246-200006000-00025

S. Wassmer, J. De-souza, C. Frere, F. Candal, and I. Juhan-vague, TGF-??1 Released from Activated Platelets Can Induce TNF-Stimulated Human Brain Endothelium Apoptosis: A New Mechanism for Microvascular Lesion during Cerebral Malaria, The Journal of Immunology, vol.176, issue.2, pp.1180-1184, 2006.
DOI : 10.4049/jimmunol.176.2.1180

W. Aird, Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms, Circulation Research, vol.100, issue.2, pp.158-173, 2007.
DOI : 10.1161/01.RES.0000255691.76142.4a

J. Hanson, S. Lam, K. Mahanta, R. Pattnaik, and S. Alam, Relative Contributions of Macrovascular and Microvascular Dysfunction to Disease Severity in Falciparum Malaria, Journal of Infectious Diseases, vol.206, issue.4, pp.571-579, 2012.
DOI : 10.1093/infdis/jis400

S. Chakravorty, C. Carret, G. Nash, A. Ivens, and T. Szestak, Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective?, International Journal for Parasitology, vol.37, issue.8-9, pp.975-987, 2007.
DOI : 10.1016/j.ijpara.2007.02.006

R. Elias, M. Correa-costa, C. Barreto, R. Silva, and C. Hayashida, Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection, PLoS ONE, vol.7, issue.8, p.44004, 2012.
DOI : 10.1371/journal.pone.0044004.g009

L. Schofield, S. Novakovic, P. Gerold, R. Schwarz, and M. Mcconville, Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction, J Immunol, vol.156, pp.1886-1896, 1996.

J. Peters, E. Fowler, D. Krause, Q. Cheng, and M. Gatton, Transcription during Adaptation to Culture, The Journal of Infectious Diseases, vol.195, issue.5, pp.748-755, 2007.
DOI : 10.1086/511436

F. Mckenzie, D. Smith, O. Meara, W. Riley, and E. , Chapter 1 Strain Theory of Malaria, Adv Parasitol, vol.66, pp.1-46, 2008.
DOI : 10.1016/S0065-308X(08)00201-7

L. Schofield, M. Hewitt, K. Evans, M. Siomos, and P. Seeberger, Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria, Nature, vol.8, issue.6899, pp.785-789, 2002.
DOI : 10.1084/jem.192.11.1563

C. Hemmer, M. Lobermann, M. Unverricht, A. Vogt, and R. Krause, Activated protein C protects vascular endothelial cells from apoptosis in malaria and in sepsis, Tropical Medicine & International Health, vol.37, issue.8, pp.906-913, 2011.
DOI : 10.1111/j.1365-3156.2011.02788.x