Skip to Main content Skip to Navigation
Journal articles

HIV-1 Vpr—a still "enigmatic multitasker"

Abstract : Like other HIV-1 auxiliary proteins, Vpr is conserved within all the human (HIV-1, HIV-2) and simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx are the only viral auxiliary proteins specifically incorporated into virus particles through direct interaction with the Gag precursor, indicating that this presence in the core of the mature virions is mainly required for optimal establishment of the early steps of the virus life cycle in the newly infected cell. In spite of its small size, a plethora of effects and functions have been attributed to Vpr, including induction of cell cycle arrest and apoptosis, modulation of the fidelity of reverse transcription, nuclear import of viral DNA in macrophages and other non-dividing cells, and transcriptional modulation of viral and host cell genes. Even if some more recent studies identified a few cellular targets that HIV-1 Vpr may utilize in order to perform its different tasks, the real role and functions of Vpr during the course of natural infection are still enigmatic. In this review, we will summarize the main reported functions of HIV-1 Vpr and their significance in the context of the viral life cycle.
Document type :
Journal articles
Complete list of metadata

Cited literature [171 references]  Display  Hide  Download
Contributor : Mireille Bos Connect in order to contact the contributor
Submitted on : Tuesday, October 28, 2014 - 2:24:27 PM
Last modification on : Wednesday, October 27, 2021 - 2:51:24 PM
Long-term archiving on: : Friday, April 14, 2017 - 12:01:37 PM


Publisher files allowed on an open archive




Carolin A Guenzel, Cécile Hérate, Serge Benichou. HIV-1 Vpr—a still "enigmatic multitasker". Frontiers in Microbiology, Frontiers Media, 2014, pp.127. ⟨10.3389/fmicb.2014.00127⟩. ⟨inserm-01078252⟩



Record views


Files downloads