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Imaging visceral adhesion to polymeric mesh using pneumoperitoneal-MRI in an experimental rat model

Abstract : Background: Intraperitoneal mesh implantation is often associated with formation of adhesion to the mesh. This experimental study examines the potential of minimally invasive pneumoperitoneal-MRI to assess these adhesions in a preclinical context. Methods: Uncoated polyethylene terephthalate meshes were placed intraperitoneally in rats, in regard to the caecum previously scraped to promote petechial bleeding and subsequent adhesions. Examinations were performed 2-weeks post mesh implantation using a rodent dedicated high field MRI. Respiratory-triggered T2 weighted images were acquired prior to and after intraperitoneal injection of ~8-10mL gas to induce a mechanical stress on the abdominal wall. Results Adhesions are occasionally seen in sham operated rats as opposed to rats receiving polyethylene terephthalate meshes. On high-resolution images, meshes can be detected due to their characteristic net-shape. Angers.. However, evidence of adherence is only found if intraperitoneal gas injection is performed, when a ~1-cm elevation of the abdominal wall is observed. When adherence occurs between the mesh and the caecum, the latter remains in contact with the wall. Looser adherences between visceral tissue and meshes are also observed. Conclusions T2-weighted pneumoperitoneal-MR imaging is a powerful tool for assessing adherence after intraperitoneal mesh implantation. According to the mini-invasive procedure adopted here, this approach may allow a temporal follow-up of adherence fate.
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Contributor : Laurent Lemaire Connect in order to contact the contributor
Submitted on : Tuesday, October 28, 2014 - 8:34:12 AM
Last modification on : Monday, May 9, 2022 - 1:36:01 PM
Long-term archiving on: : Thursday, January 29, 2015 - 10:13:24 AM


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Florence Franconi, Jérome Roux, Céline Lefebvre-Lacoeuille, Laurent Lemaire. Imaging visceral adhesion to polymeric mesh using pneumoperitoneal-MRI in an experimental rat model. Surgical Endoscopy, Springer Verlag (Germany), 2015, 2014, in press. ⟨10.1007/s00464-014-3843-9⟩. ⟨inserm-01078106⟩



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