Exhaled nitric oxide, nitrite/nitrate levels, allergy, rhinitis and asthma in the EGEA study.

Rachel Nadif 1 Marta Rava 1 Brigitte Decoster 2 Hélène Huyvaert 3, 2 Nicole Le Moual 1 Jean Bousquet 1, 4 Valérie Siroux 5 Raphaëlle Varraso 1 Isabelle Pin 5, 6 Farid Zerimech 3 Régis Matran 2
1 CESP - Centre de recherche en épidémiologie et santé des populations
2 Université Lille Nord de France
3 Laboratoire de biochimie
4 CHU Arnaud de Villeneuve
5 INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
6 Service de pédiatrie
Abstract : Although interest in biomarkers in the nitrate-nitrite-NO pathway has recently increased, associations between nitrite (NO2(-)) and nitrate (NO3(-)), and asthma, allergic sensitisation and rhinitis remain unclear. The study aimed to evaluate the associations between NO2(-)/NO3(-) and exhaled fraction of nitric oxide (FeNO) levels with asthma, allergic sensitisation and rhinitis. Plasma and exhaled breath condensate (EBC) NO2(-)/NO3(-) and FeNO levels were measured in 523 adults of the French Epidemiological study on Genetics and Environment of Asthma. Allergic sensitisation was defined by a positive skin prick test for at least one aeroallergen. Subjects were classified as non-sensitised, sensitised and as having allergic rhinitis. Plasma NO2 (-)/NO3(-) level was unrelated to any disease phenotypes. EBC NO2(-)/NO3(-) level was unrelated to any asthma phenotypes. EBC NO2(-)/NO3(-) and FeNO levels were correlated in sensitised subjects only (r = 0.21 ± 0.10, p=0.01). EBC NO2(-)/NO3(-) and FeNO levels were higher in sensitised than in non-sensitised subjects (adjusted geometric mean (95% CI): 2.36 (1.96-2.84) versus 1.72 (1.38-2.14) μmol per mg proteins, p=0.008; and 18.3 (16.7-20.0) versus 14.8 (13.3-16.5) ppb, p=0.0006, respectively), with gradual relationships from sensitised subjects to those with allergic rhinitis (p<0.0001). Results suggest that EBC NO2(-)/NO3(-) and FeNO levels may be considered as biological markers of intensity of allergic sensitisation and rhinitis.
Keywords : exhaled breath condensate exhaled fraction of NO allergic sensitization rhinitis total nitrite/nitrate asthma adults NO metabolism
Type de document :
Article dans une revue
European Respiratory Journal, European Respiratory Society, 2014, 44 (2), pp.351-60. 〈10.1183/09031936.00202413〉
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Dernière modification le : mercredi 10 janvier 2018 - 10:12:02
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U823 | CESP | EGEA | UVSQ | UGA

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Rachel Nadif, Marta Rava, Brigitte Decoster, Hélène Huyvaert, Nicole Le Moual, et al.. Exhaled nitric oxide, nitrite/nitrate levels, allergy, rhinitis and asthma in the EGEA study.. European Respiratory Journal, European Respiratory Society, 2014, 44 (2), pp.351-60. 〈10.1183/09031936.00202413〉. 〈inserm-01077107〉

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