Visual Versus Quantitative Assessment of Intratumor 18F-FDG PET Uptake Heterogeneity: Prognostic Value in Non-Small Cell Lung Cancer.

Florent Tixier; Mathieu Hatt; Clémence Valla; Vincent Fleury; Corinne Lamour; Safaa Ezzouhri; Pierre Ingrand; Remy Perdrisot; Dimitris Visvikis; Catherine Cheze Le Rest

Abstract : The goal of this study was to compare visual assessment of intra-tumor 18F-FDG PET uptake distribution with a textural features (TF) automated quantification and to establish their respective prognostic value in non-small cell lung cancer (NSCLC). METHODS: The study retrospectively included 102 consecutive patients. Only primary tumors were considered. Intra-tumor heterogeneity was visually scored (3-level scale (Hvisu)) by two nuclear medicine physicians. Tumor volumes were automatically delineated and heterogeneity was quantified with TF. Mean and maximum SUV were also included. Visual inter-observer agreement and correlations with quantitative assessment were evaluated using the Kappa test and Spearman rank (r) coefficient respectively. Association with overall survival (OS) and recurrence-free survival (RFS) was investigated using the Kaplan-Meier method and Cox regression models. RESULTS: Moderate correlations (0.4

Keywords : heterogeneity 18FDG-PET/CT NSCLC textural features prognosis

Type de document :

Article dans une revue

Journal of Nuclear Medicine, Society of Nuclear Medicine, 2014, 55 (8), pp.1235-1241

Domaine :

Sciences du Vivant [q-bio] / Ingénierie biomédicale / Médecine nucléaire

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http://www.hal.inserm.fr/inserm-01074715
Contributeur : Mathieu Hatt <>
Soumis le : mercredi 15 octobre 2014 - 11:47:31
Dernière modification le : jeudi 20 septembre 2018 - 15:03:29
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Visual Versus Quantitative Assessment of Intratumor 18F-FDG PET Uptake Heterogeneity: Prognostic Value in Non-Small Cell Lung Cancer.: FDG PET heterogeneity in NSCLC

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