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Visual Versus Quantitative Assessment of Intratumor 18F-FDG PET Uptake Heterogeneity: Prognostic Value in Non-Small Cell Lung Cancer.: FDG PET heterogeneity in NSCLC

Abstract : The goal of this study was to compare visual assessment of intra-tumor 18F-FDG PET uptake distribution with a textural features (TF) automated quantification and to establish their respective prognostic value in non-small cell lung cancer (NSCLC). METHODS: The study retrospectively included 102 consecutive patients. Only primary tumors were considered. Intra-tumor heterogeneity was visually scored (3-level scale (Hvisu)) by two nuclear medicine physicians. Tumor volumes were automatically delineated and heterogeneity was quantified with TF. Mean and maximum SUV were also included. Visual inter-observer agreement and correlations with quantitative assessment were evaluated using the Kappa test and Spearman rank (r) coefficient respectively. Association with overall survival (OS) and recurrence-free survival (RFS) was investigated using the Kaplan-Meier method and Cox regression models. RESULTS: Moderate correlations (0.4
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https://www.hal.inserm.fr/inserm-01074715
Contributor : Mathieu Hatt <>
Submitted on : Wednesday, October 15, 2014 - 11:47:31 AM
Last modification on : Wednesday, June 24, 2020 - 4:18:10 PM
Long-term archiving on: : Friday, January 16, 2015 - 10:16:37 AM

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  • HAL Id : inserm-01074715, version 1
  • PUBMED : 24904113

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Florent Tixier, Mathieu Hatt, Clémence Valla, Vincent Fleury, Corinne Lamour, et al.. Visual Versus Quantitative Assessment of Intratumor 18F-FDG PET Uptake Heterogeneity: Prognostic Value in Non-Small Cell Lung Cancer.: FDG PET heterogeneity in NSCLC. Journal of Nuclear Medicine, Society of Nuclear Medicine, 2014, 55 (8), pp.1235-1241. ⟨inserm-01074715⟩

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