F. The, U. Consortium, J. Lathrop, K. Hager-jeremy, and . Nicholson, The Wellcome Trust Centre for Human Genetics CEA-Genomics Institute, Centre National de Génotypage

I. T. Watson-research and . Centre, Yorktown Hgts, NY 10598, USA. 5 CEA-Genomics Institute, Centre National de Génotypage, Evry 91057, France. 6 The Wellcome Trust Centre for Human Genetics, 7 INSERM UMRS872, Centre de Recherche des Cordeliers, 15 Rue de l'école de Médecine, 11022801.

A. Abchee, H. Puzantian, S. Azar, H. Shbaklo, A. Nasrallah et al., Predictors of coronary artery disease in the Lebanese population, Thrombosis Research, vol.117, issue.6, pp.631-637, 2006.
DOI : 10.1016/j.thromres.2005.05.022

R. Alexander, Hypertension and the Pathogenesis of Atherosclerosis : Oxidative Stress and the Mediation of Arterial Inflammatory Response: A New Perspective, Hypertension, vol.25, issue.2, pp.155-161, 1995.
DOI : 10.1161/01.HYP.25.2.155

M. Arnaout, W. Almahmeed, M. Ibrahim, J. Ker, M. Khalil et al., Hypertension and its management in countries in Africa and the Middle East, with special reference to the place of beta-blockade, Al Mousa E, 2011.

J. Balligand, ??3-Adrenoceptor Stimulation on Top of ??1-Adrenoceptor Blockade, Journal of the American College of Cardiology, vol.53, issue.17, pp.1539-1542, 2009.
DOI : 10.1016/j.jacc.2009.01.048

R. Benfante, D. Reed, C. Maclean, and K. Yano, Risk factors in middle age that predict early and late onset of coronary heart disease, Journal of Clinical Epidemiology, vol.42, issue.2, pp.95-104, 1989.
DOI : 10.1016/0895-4356(89)90082-6

C. Besler, C. Doerries, G. Giannotti, T. Lüscher, and U. Landmesser, Pharmacological approaches to improve endothelial repair mechanisms, Expert Review of Cardiovascular Therapy, vol.6, issue.8, pp.1071-1082, 2008.
DOI : 10.1586/14779072.6.8.1071

L. Chen, M. Chester, and J. Kaski, Clinical Factors and Angiographic Features Associated With Premature Coronary Artery Disease, Chest, vol.108, issue.2, pp.364-369, 1995.
DOI : 10.1378/chest.108.2.364

R. Collins, R. Peto, S. Macmahon, P. Hebert, N. Fiebach et al., Blood pressure, stroke, and coronary heart disease, The Lancet, vol.335, issue.8693, pp.827-838, 1990.
DOI : 10.1016/0140-6736(90)90944-Z

C. Cuspidi, F. Negri, V. Giudici, A. Capra, and C. Sala, Effects of antihypertensive drugs on carotid intima-media thickness: Focus on angiotensin II receptor blockers. A review of randomized, controlled trials, Integrated Blood Pressure Control, vol.2, pp.1-8, 2009.
DOI : 10.2147/IBPC.S5174

B. Dahlof, R. Devereux, S. Kjeldsen, J. S. Beevers, G. De-faire et al., Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol, The Lancet, vol.359, issue.9311, pp.995-1003, 2002.
DOI : 10.1016/S0140-6736(02)08089-3

T. Dawber, W. Kannel, N. Revotskie, J. Stokes-3rd, A. Kagan et al., Some Factors Associated with the Development of Coronary Heart Disease???Six Years' Follow-Up Experience in the Framingham Study, American Journal of Public Health and the Nations Health, vol.49, issue.10, pp.1349-1356, 1959.
DOI : 10.2105/AJPH.49.10.1349

J. Ioannidis, Prediction of Cardiovascular Disease Outcomes and Established Cardiovascular Risk Factors by Genome-Wide Association Markers, Circulation: Cardiovascular Genetics, vol.2, issue.1, pp.7-15, 2009.
DOI : 10.1161/CIRCGENETICS.108.833392

T. Lakka, R. Salonen, G. Kaplan, and J. Salonen, Blood Pressure and the Progression of Carotid Atherosclerosis in Middle-Aged Men, Hypertension, vol.34, issue.1, pp.51-56, 1999.
DOI : 10.1161/01.HYP.34.1.51

S. Lewington, R. Clarke, N. Qizilbash, R. Peto, and R. Collins, Prospective Studies Collaboration Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies, Lancet, vol.360, pp.1903-1913, 2002.

L. Jjchen and J. , Inflammation may be a bridge connecting hypertension and atherosclerosis, Med Hypotheses, vol.64, pp.925-929, 2005.

A. Mackenzie, Endothelium-derived vasoactive agents, AT1 receptors and inflammation, Pharmacology & Therapeutics, vol.131, issue.2, pp.187-203, 2011.
DOI : 10.1016/j.pharmthera.2010.11.001

S. Macmahon, R. Peto, J. Cutler, R. Collins, P. Sorlie et al., Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias, The Lancet, vol.335, issue.8692, pp.765-774, 1990.
DOI : 10.1016/0140-6736(90)90878-9

A. Menotti, D. Kromhout, H. Blackburn, D. Jacobs, and M. Lanti, Early and late coronary deaths in the US Railroad study predicted by major coronary risk factors, European Journal of Cardiovascular Prevention & Rehabilitation, vol.82, issue.1, pp.382-388, 2004.
DOI : 10.1097/00149831-200410000-00004

J. Keefe, M. Carter, and C. Lavie, Primary and Secondary Prevention of Cardiovascular Diseases: A Practical Evidence-Based Approach, Mayo Clinic Proceedings, vol.84, issue.8, pp.741-757, 2009.
DOI : 10.4065/84.8.741

R. Papp, A. Csaszar, E. Paulik, and S. Balogh, Correlations between prescription of anti-hypertensive medication and mortality due to stroke, BMC Cardiovascular Disorders, vol.356, issue.9227, p.15, 2012.
DOI : 10.1016/S0140-6736(00)02526-5

C. Pepine, E. Handberg, R. Cooper-dehoff, R. Marks, P. Kowey et al., A calcium antagonist vs. a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease: the international verapamil-trandolapril study (INVEST): a randomized controlled trial, ACC Current Journal Review, vol.13, issue.2, pp.2805-2816, 2003.
DOI : 10.1016/j.accreview.2003.12.023

B. Psaty, T. Lumley, C. Furberg, G. Schellenbaum, M. Pahor et al., Health Outcomes Associated With Various Antihypertensive Therapies Used as First-Line Agents, JAMA, vol.289, issue.19, pp.2534-2544, 2003.
DOI : 10.1001/jama.289.19.2534

R. Reibis, A. Treszl, K. Wegscheider, K. Bestehorn, B. Karmann et al., Disparity in risk factor pattern in premature versus late-onset coronary artery disease: a survey of 15,381 patients, Vascular Health and Risk Management, vol.8, pp.473-481, 2012.
DOI : 10.2147/VHRM.S33305

R. Sadeghi, N. Adnani, A. Erfanifar, L. Gachkar, and Z. Maghsoomi, Premature coronary heart disease and traditional risk factors-can we do better?, Int Cardiovasc Res J, vol.7, pp.46-50, 2013.

C. Sengul, O. Ozveren, C. Cevik, C. Izgi, Y. Karavelio?lu et al., Comparison of psychosocial risk factors between patients who experience acute myocardial infarction before and after 40 years of age, Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, vol.39, issue.5, pp.396-402, 2011.
DOI : 10.5543/tkda.2011.01412

A. Sibai, A. Fletcher, M. Hills, and O. Campbell, Non-communicable disease mortality rates using the verbal autopsy in a cohort of middle aged and older populations in Beirut during wartime, J Epidemiol Community Health, vol.55, pp.1983-93271, 2001.

S. Alevenson and J. , Effects of calcium channel blockers on atherosclerosis: new insights, Acta Cardiol, vol.57, pp.249-255, 2002.

I. Sipahi, E. Tuzcu, K. Wolski, S. Nicholls, P. Schoenhagen et al., ??-Blockers and Progression of Coronary Atherosclerosis: Pooled Analysis of 4 Intravascular Ultrasonography Trials, Annals of Internal Medicine, vol.147, issue.1, pp.10-18, 2007.
DOI : 10.7326/0003-4819-147-1-200707030-00003

T. Slavin, T. Feng, A. Schnell, X. Zhu, and R. Elston, Two-marker association tests yield new disease associations for coronary artery disease and hypertension, Human Genetics, vol.34, issue.6, pp.725-733, 2011.
DOI : 10.1007/s00439-011-1009-6

R. Tate, J. Manfreda, and T. Cuddy, The Effect of Age on Risk Factors for Ischemic Heart Disease, Annals of Epidemiology, vol.8, issue.7, pp.1948-1993, 1998.
DOI : 10.1016/S1047-2797(98)00011-8

R. Tohme, A. Jurjus, and A. Estephan, The prevalence of hypertension and its association with other cardiovascular disease risk factors in a representative sample of the Lebanese population, Journal of Human Hypertension, vol.109, issue.11, pp.861-868, 2005.
DOI : 10.1038/sj.jhh.1001909

A. Tropeano, N. Saleh, N. Hawajri, I. Macquin-mavier, and M. P. , Do all antihypertensive drugs improve carotid intima-media thickness????A network meta-analysis of randomized controlled trials, Fundamental & Clinical Pharmacology, vol.22, issue.Suppl, pp.395-404, 2011.
DOI : 10.1111/j.1472-8206.2010.00832.x

W. Ketopol and E. , Pathobiology of atherosclerosis: are there racial and ethnic differences?, Rev Cardiovasc Med, vol.5, pp.14-21, 2004.

W. White, Angiotensin-Converting Enzyme Inhibitors in the Treatment of Hypertension: An Update, The Journal of Clinical Hypertension, vol.28, issue.2, pp.876-882, 2007.
DOI : 10.1111/j.1524-6175.2007.07782.x

S. Youhanna, D. Platt, A. Rebeiz, M. Lauridsen, M. Deeb et al., Parental consanguinity and family history of coronary artery disease strongly predict early stenosis, Atherosclerosis, vol.212, issue.2, pp.559-563, 2010.
DOI : 10.1016/j.atherosclerosis.2010.07.013

S. Yusuf, P. Sleight, J. Pogue, J. Bosch, R. Davies et al., Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators, N Engl J Med, vol.342, pp.145-153, 2000.

X. Zhu, T. Feng, Y. Li, Q. Lu, and R. Elston, Detecting rare variants for complex traits using family and unrelated data, Genetic Epidemiology, vol.14, issue.2, pp.171-187, 2010.
DOI : 10.1002/gepi.20449

A. Zuhdi, J. Mariapun, M. Hairi, N. , W. Ahmad et al., Young coronary artery disease in patients undergoing percutaneous coronary intervention, Annals of Saudi Medicine, vol.33, issue.6, pp.572-578, 2013.
DOI : 10.5144/0256-4947.2013.572