Detection of RHDV strains in the Iberian hare ( Lepus granatensis ): earliest evidence of rabbit lagovirus cross-species infection.

Ana Lopes 1, 2, 3 Sara Marques 2 Eliane Silva 2, 4 Maria Magalhães 2 Ana Pinheiro 2, 3, 5 Paulo Alves 2, 3, 6 Jacques Le Pendu 1 Pedro Esteves 2, 3, 7 Gertrude Thompson 2, 4 Joana Abrantes 1, 2, *
* Auteur correspondant
1 CRCNA - Centre de Recherche en Cancérologie / Nantes - Angers
2 CIBIO-UP - Centro de Investigação em Biodiversidade e Recursos Genéticos
3 Departamento de Biologia
4 Departamento de Clínicas Veterinárias
5 IREC - Instituto de Investigación en Recursos Cinegéticos
6 Wildlife Biology Program
7 Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
Abstract : : Rabbit hemorrhagic disease virus (RHDV) is a highly lethal Lagovirus, family Caliciviridae, that threatens European rabbits (Oryctolagus cuniculus). Although a related virus severely affects hares, cross-species infection was only recently described for new variant RHDV2 in Cape hares (Lepus capensis). We sequenced two strains from dead Iberian hares (Lepus granatensis) collected in the 1990s in Portugal. Clinical signs were compatible with a Lagovirus infection. Phylogenetic analysis of the complete capsid gene positioned them in the RHDV genogroup that circulated on the Iberian Peninsula at that time. This is the earliest evidence of RHDV affecting a species other than European rabbits.
Type de document :
Article dans une revue
Veterinary Research, BioMed Central, 2014, 45 (1), pp.94. 〈10.1186/PREACCEPT-2643101671316388〉
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Ana Lopes, Sara Marques, Eliane Silva, Maria Magalhães, Ana Pinheiro, et al.. Detection of RHDV strains in the Iberian hare ( Lepus granatensis ): earliest evidence of rabbit lagovirus cross-species infection.. Veterinary Research, BioMed Central, 2014, 45 (1), pp.94. 〈10.1186/PREACCEPT-2643101671316388〉. 〈inserm-01072010〉

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