M. Agromayor, N. Soler, A. Caballe, T. Kueck, S. M. Freund et al., The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain, Structure, vol.20, issue.3, pp.414-428, 2012.
DOI : 10.1016/j.str.2011.12.013

E. Bailes, F. Gao, F. Bibollet-ruche, V. Courgnaud, M. Peeters et al., Hybrid Origin of SIV in Chimpanzees, Science, vol.300, issue.5626, 2003.
DOI : 10.1126/science.1080657

C. Besnard-guerin, N. Belaidouni, I. Lassot, E. Segeral, A. Jobart et al., HIV-1 Vpu Sequesters ??-Transducin Repeat-containing Protein (??TrCP) in the Cytoplasm and Provokes the Accumulation of ??-Catenin and Other SCF??TrCP Substrates, Journal of Biological Chemistry, vol.279, issue.1, pp.788-795, 2004.
DOI : 10.1074/jbc.M308068200

S. Bour, C. Perrin, H. Akari, and K. Strebel, The Human Immunodeficiency Virus Type 1 Vpu Protein Inhibits NF-??B Activation by Interfering with ??TrCP-mediated Degradation of I??B, Journal of Biological Chemistry, vol.276, issue.19, pp.15920-15928, 2001.
DOI : 10.1074/jbc.M010533200

M. Caillet, K. Janvier, A. Pelchen-matthews, D. Delcroix-genete, G. Camus et al., Rab7A Is Required for Efficient Production of Infectious HIV-1, PLoS Pathogens, vol.2, issue.11, 2011.
DOI : 10.1371/journal.ppat.1002347.s006

URL : https://hal.archives-ouvertes.fr/inserm-00693726

N. Casartelli, M. Sourisseau, J. Feldmann, F. Guivel-benhassine, A. Mallet et al., Tetherin restricts productive HIV-1 cellto-cell transmission, PLoS Pathog, 2010.

R. Chaudhuri, O. W. Lindwasser, W. J. Smith, J. H. Hurley, and B. , Downregulation of CD4 by human immunodeficiency virus type 1, J. S, 2007.

L. J. Cocka and P. Bates, Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling Activities, PLoS Pathogens, vol.8, issue.9, 2012.
DOI : 10.1371/journal.ppat.1002931.s007

V. Courgnaud, P. Formenty, C. Akoua-koffi, R. Noe, C. Boesch et al., Partial Molecular Characterization of Two Simian Immunodeficiency Viruses (SIV) from African Colobids: SIVwrc from Western Red Colobus (Piliocolobus badius) and SIVolc from Olive Colobus (Procolobus verus), Journal of Virology, vol.77, issue.1, pp.744-748, 2003.
DOI : 10.1128/JVI.77.1.744-748.2003

V. Courgnaud, M. Salemi, X. Pourrut, E. Mpoudi-ngole, B. Abela et al., Characterization of a Novel Simian Immunodeficiency Virus with a vpu Gene from Greater Spot-Nosed Monkeys (Cercopithecus nictitans) Provides New Insights into Simian/Human Immunodeficiency Virus Phylogeny, Journal of Virology, vol.76, issue.16, pp.8298-8309, 2002.
DOI : 10.1128/JVI.76.16.8298-8309.2002

B. Crise, L. Buonocore, R. , and J. K. , CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor, J. Virol, vol.64, pp.5585-5593, 1990.

J. L. Douglas, K. Viswanathan, M. N. Mccarroll, J. K. Gustin, K. Fruh et al., Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a ??TrCP-Dependent Mechanism, Journal of Virology, vol.83, issue.16, pp.7931-7947, 1128.
DOI : 10.1128/JVI.00242-09

M. Dube, C. Paquay, B. B. Roy, M. G. Bego, J. Mercier et al., HIV-1 Vpu Antagonizes BST-2 by Interfering Mainly with the Trafficking of Newly Synthesized BST-2 to the Cell Surface, Traffic, vol.78, issue.3, pp.1714-1729, 2011.
DOI : 10.1111/j.1600-0854.2011.01277.x

R. P. Galao, L. Tortorec, A. Pickering, S. Kueck, T. et al., Innate Sensing of HIV-1 Assembly by Tetherin Induces NF??B-Dependent Proinflammatory Responses, Cell Host & Microbe, vol.12, issue.5, pp.633-644, 2012.
DOI : 10.1016/j.chom.2012.10.007

F. Gao, E. Bailes, D. L. Robertson, Y. Chen, C. M. Rodenburg et al., Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes, Nature, vol.397, issue.6718, pp.436-441, 1038.
DOI : 10.1038/17130

C. Goffinet, I. Allespach, S. Homann, H. M. Tervo, A. Habermann et al., HIV-1 Antagonism of CD317 Is Species Specific and Involves Vpu-Mediated Proteasomal Degradation of the Restriction Factor, Cell Host & Microbe, vol.5, issue.3, pp.285-297, 2009.
DOI : 10.1016/j.chom.2009.01.009

C. Goffinet, S. Homann, I. Ambiel, N. Tibroni, D. Rupp et al., Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu, Journal of Virology, vol.84, issue.8, pp.4089-4094, 1128.
DOI : 10.1128/JVI.01549-09

S. Gummuluru, C. M. Kinsey, and M. Emerman, An in vitro rapid-turnover assay for human immunodeficiency virus type 1 replication selects for cell-tocell spread of virus, J. Virol, vol.74, 2000.

R. K. Gupta, S. Hue, T. Schaller, E. Verschoor, D. Pillay et al., Mutation of a single residue renders human tetherin resistant to HIV-1, 2009.

R. K. Gupta, P. Mlcochova, A. Pelchen-matthews, S. J. Petit, G. Mattiuzzo et al., Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration, Proceedings of the National Academy of Sciences, vol.106, issue.49, pp.20889-20894, 2009.
DOI : 10.1073/pnas.0907075106

J. K. Gustin, J. L. Douglas, Y. Bai, and A. V. Moses, Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not Require Lysine, Serine, or Threonine Residues within the BST-2 Cytoplasmic Domain, Journal of Biological Chemistry, vol.287, issue.18, pp.14837-14850, 2012.
DOI : 10.1074/jbc.M112.349928

A. Habermann, J. Krijnse-locker, H. Oberwinkler, M. Eckhardt, S. Homann et al., CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection, Journal of Virology, vol.84, issue.9, pp.4646-4658, 1128.
DOI : 10.1128/JVI.02421-09

J. Hammonds, J. J. Wang, H. Yi, and P. Spearman, Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma Membrane, PLoS Pathogens, vol.74, issue.11, 2010.
DOI : 10.1371/journal.ppat.1000749.s003

H. Hauser, L. A. Lopez, S. J. Yang, J. E. Oldenburg, C. M. Exline et al., HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment, Retrovirology, vol.7, issue.1, pp.51-61, 2010.
DOI : 10.1186/1742-4690-7-51

M. S. Hill, A. Ruiz, K. Schmitt, and E. B. Stephens, Identification of amino acids within the second alpha helical domain of the human immunodeficiency virus type 1 Vpu that are critical for preventing CD4 cell surface expression, Virology, vol.397, issue.1, pp.104-112, 2010.
DOI : 10.1016/j.virol.2009.10.048

Y. Iwabu, H. Fujita, M. Kinomoto, K. Kaneko, Y. Ishizaka et al., HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes, Journal of Biological Chemistry, vol.284, issue.50, pp.35060-35072, 2009.
DOI : 10.1074/jbc.M109.058305

M. A. Jabbar and D. P. Nayak, Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane, J. Virol, vol.64, pp.6297-6304, 1990.

K. Janvier, A. Pelchen-matthews, J. B. Renaud, M. Caillet, M. Marsh et al., The ESCRT-0 component HRS is required for HIV-1, 2011.

K. Janvier, N. Roy, and C. Berlioz-torrent, Role of the Endosomal ESCRT Machinery in HIV-1 Vpu-Induced Down- Regulation of BST2/Tetherin, Current HIV Research, vol.10, issue.4, pp.315-320, 2012.
DOI : 10.2174/157016212800792414

URL : https://hal.archives-ouvertes.fr/inserm-00693708

B. Jia, R. Serra-moreno, W. Neidermyer, A. Rahmberg, J. Mackey et al., Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2, PLoS Pathogens, vol.213, issue.5, 2009.
DOI : 10.1371/journal.ppat.1000429.g009

C. Jolly, N. J. Booth, N. , and S. J. , Cell-Cell Spread of Human Immunodeficiency Virus Type 1 Overcomes Tetherin/BST-2-Mediated Restriction in T cells, Journal of Virology, vol.84, issue.23, pp.12185-12199, 2010.
DOI : 10.1128/JVI.01447-10

T. Kobayashi, H. Ode, T. Yoshida, K. Sato, P. Gee et al., Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility, Journal of Virology, vol.85, issue.2, pp.932-945, 2011.
DOI : 10.1128/JVI.01668-10

T. Kueck, N. , and S. J. , A cytoplasmic tail determinant in HIV-1, 2012.

S. Kupzig, V. Korolchuk, R. Rollason, A. Sugden, A. Wilde et al., Bst-2/HM1.24 Is a Raft-Associated Apical Membrane Protein with an Unusual Topology, Traffic, vol.29, issue.2, pp.694-709, 2003.
DOI : 10.1034/j.1600-0854.2003.00129.x

N. Laguette, B. Sobhian, N. Casartelli, M. Ringeard, C. Chable-bessia et al., SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx, Nature, vol.38, issue.7353, pp.654-657, 1038.
DOI : 10.1038/nature10117

URL : https://hal.archives-ouvertes.fr/hal-00616451

D. Lau, W. Kwan, and J. Guatelli, Role of the Endocytic Pathway in the Counteraction of BST-2 by Human Lentiviral Pathogens, Journal of Virology, vol.85, issue.19, pp.9834-9846, 2011.
DOI : 10.1128/JVI.02633-10

L. Tortorec, A. , N. , and S. J. , Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope Glycoprotein, Journal of Virology, vol.83, issue.22, pp.11966-11978, 2009.
DOI : 10.1128/JVI.01515-09

J. G. Magadan and J. S. Bonifacino, Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu, Journal of Virology, vol.86, issue.2, pp.757-772, 2012.
DOI : 10.1128/JVI.05933-11

J. G. Magadan, F. J. Perez-victoria, R. Sougrat, Y. Ye, K. Strebel et al., Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps, PLoS Pathogens, vol.19, issue.4, 2010.
DOI : 10.1371/journal.ppat.1000869.s005

F. Maldarelli, M. Y. Chen, R. L. Willey, and K. Strebel, Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein, J. Virol, vol.67, pp.5056-5061, 1993.

M. H. Malim and P. D. Bieniasz, HIV Restriction factors and mechanisms of evasion. Cold Spring Harb, 2012.

M. H. Malim and M. Emerman, HIV-1 Accessory Proteins???Ensuring Viral Survival in a Hostile Environment, Cell Host & Microbe, vol.3, issue.6, 2008.
DOI : 10.1016/j.chom.2008.04.008

B. Mangeat, G. Gers-huber, M. Lehmann, M. Zufferey, J. Luban et al., HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation, PLoS Pathogens, vol.213, issue.9, 2009.
DOI : 10.1371/journal.ppat.1000574.g009

F. Margottin, S. P. Bour, H. Durand, L. Selig, S. Benichou et al., A Novel Human WD Protein, h-??TrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif, Molecular Cell, vol.1, issue.4, pp.565-574, 1998.
DOI : 10.1016/S1097-2765(00)80056-8

N. Masuyama, T. Kuronita, R. Tanaka, T. Muto, Y. Hirota et al., HM1.24 Is Internalized from Lipid Rafts by Clathrin-mediated Endocytosis through Interaction with ??-Adaptin, Journal of Biological Chemistry, vol.284, issue.23, pp.15927-15941, 2009.
DOI : 10.1074/jbc.M109.005124

A. Matsuda, Y. Suzuki, G. Honda, S. Muramatsu, O. Matsuzaki et al., Large-scale identification and characterization of human genes that activate NF-??B and MAPK signaling pathways, Oncogene, vol.22, issue.21, pp.3307-3318, 2003.
DOI : 10.1038/sj.onc.1206406

M. W. Mcnatt, T. Zang, and P. D. Bieniasz, Vpu Binds Directly to Tetherin and Displaces It from Nascent Virions, PLoS Pathogens, vol.7, issue.4, 2013.
DOI : 10.1371/journal.ppat.1003299.s003

R. S. Mitchell, C. Katsura, M. A. Skasko, K. Fitzpatrick, D. Lau et al., Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking, PLoS Pathog, 2009.

E. Miyagi, A. J. Andrew, S. Kao, and K. Strebel, Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion, Proceedings of the National Academy of Sciences, vol.106, issue.8, pp.2868-2873, 2009.
DOI : 10.1073/pnas.0813223106

M. Moll, S. K. Andersson, A. Smed-sorensen, and J. K. Sandberg, Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments, Blood, vol.116, issue.11, pp.1876-1884, 2010.
DOI : 10.1182/blood-2009-09-243667

S. J. Neil, The Antiviral Activities of Tetherin, Curr. Top. Microbiol. Immunol, vol.371, pp.67-104, 2013.
DOI : 10.1007/978-3-642-37765-5_3

S. J. Neil, T. Zang, and P. D. Bieniasz, Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu, Nature, vol.2, issue.7177, pp.425-430, 2008.
DOI : 10.1038/nature06553

C. Pardieu, R. Vigan, S. J. Wilson, A. Calvi, T. Zang et al., The RING-CH Ligase K5 Antagonizes Restriction of KSHV and HIV-1 Particle Release by Mediating Ubiquitin-Dependent Endosomal Degradation of Tetherin, PLoS Pathogens, vol.1, issue.4, 2010.
DOI : 10.1371/journal.ppat.1000843.s002

D. Perez-caballero, T. Zang, A. Ebrahimi, M. W. Mcnatt, D. A. Gregory et al., Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells, Cell, vol.139, issue.3, pp.499-511, 2009.
DOI : 10.1016/j.cell.2009.08.039

S. Pickering, S. Hue, E. Y. Kim, S. Reddy, S. M. Wolinsky et al., Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals, PLoS Pathogens, vol.26, issue.1, 2014.
DOI : 10.1371/journal.ppat.1003895.s008

C. Raiborg, H. Stenmark, N. Ray, and R. W. Doms, The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins HIV-1 coreceptors and their inhibitors, Nature Curr. Top. Microbiol. Immunol, vol.458, issue.303, pp.445-452, 2006.

D. Sauter, M. Schindler, A. Specht, W. N. Landford, J. Munch et al., Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains, Cell Host & Microbe, vol.6, issue.5, pp.409-421, 2009.
DOI : 10.1016/j.chom.2009.10.004

H. L. Schubert, Q. Zhai, V. Sandrin, D. M. Eckert, M. Garcia-maya et al., Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations, Proceedings of the National Academy of Sciences, vol.107, issue.42, pp.17951-17956, 2010.
DOI : 10.1073/pnas.1008206107

U. Schubert, K. A. Clouse, and K. Strebel, Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes, J. Virol, vol.69, pp.7699-7711, 1995.

R. Serra-moreno, B. Jia, M. Breed, X. Alvarez, and D. T. Evans, Compensatory Changes in the Cytoplasmic Tail of gp41 Confer Resistance to Tetherin/BST-2 in a Pathogenic Nef-Deleted SIV, Cell Host & Microbe, vol.9, issue.1, pp.46-57, 2011.
DOI : 10.1016/j.chom.2010.12.005

A. H. Shah, B. Sowrirajan, Z. B. Davis, J. P. Ward, E. M. Campbell et al., Degranulation of Natural Killer Cells Following Interaction with HIV-1-Infected Cells Is Hindered by Downmodulation of NTB-A by Vpu, Cell Host & Microbe, vol.8, issue.5, pp.397-409, 2010.
DOI : 10.1016/j.chom.2010.10.008

A. M. Sheehy, N. C. Gaddis, J. D. Choi, and M. H. Malim, Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein, Nature, vol.71, issue.6898, pp.646-650, 1038.
DOI : 10.1093/emboj/16.15.4531

M. Skasko, Y. Wang, Y. Tian, A. Tokarev, J. Munguia et al., HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions, Journal of Biological Chemistry, vol.287, issue.1, pp.58-67, 2012.
DOI : 10.1074/jbc.M111.296772

B. Skaug, X. Jiang, C. , and Z. J. , The Role of Ubiquitin in NF-??B Regulatory Pathways, Annual Review of Biochemistry, vol.78, issue.1, pp.769-796, 2009.
DOI : 10.1146/annurev.biochem.78.070907.102750

K. Strebel, T. Klimkait, and M. A. Martin, A novel gene of HIV-1, vpu, and its 16-kilodalton product, Science, vol.241, issue.4870, pp.1221-1223, 1988.
DOI : 10.1126/science.3261888

M. Stremlau, C. M. Owens, M. J. Perron, M. Kiessling, P. Autissier et al., The cytoplasmic body component TRIM5?? restricts HIV-1 infection in Old World monkeys, Nature, vol.427, issue.6977, pp.848-853, 1038.
DOI : 10.1038/nature02343

H. M. Tervo, S. Homann, I. Ambiel, J. V. Fritz, O. T. Fackler et al., Beta-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release, Retrovirology, vol.8, 2011.

A. Tokarev, M. Suarez, W. Kwan, K. Fitzpatrick, R. Singh et al., Stimulation of NF-??B Activity by the HIV Restriction Factor BST2, Journal of Virology, vol.87, issue.4, pp.2046-2057, 2013.
DOI : 10.1128/JVI.02272-12

A. A. Tokarev, J. Munguia, and J. C. Guatelli, Serine-Threonine Ubiquitination Mediates Downregulation of BST-2/Tetherin and Relief of Restricted Virion Release by HIV-1 Vpu, Journal of Virology, vol.85, issue.1, pp.51-63, 2010.
DOI : 10.1128/JVI.01795-10

N. Van-damme, D. Goff, C. Katsura, R. L. Jorgenson, R. Mitchell et al., The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein, Cell Host & Microbe, vol.3, issue.4, pp.245-252, 2008.
DOI : 10.1016/j.chom.2008.03.001

S. Venkatesh and P. D. Bieniasz, Mechanism of HIV-1 Virion Entrapment by Tetherin, PLoS Pathogens, vol.76, issue.7, 2013.
DOI : 10.1371/journal.ppat.1003483.t002