D. Kalousek, The effect of confined placental mosaicism on development of the human aneuploid conceptus, Birth Defects Orig Artic Ser, vol.29, pp.39-51, 1993.

J. Liu, W. Wang, X. Sun, L. Liu, J. H. Li et al., DNA microarray reveals that high proportions of human blastocysts from women of advanced maternal age are aneuploid and mosaic, Biol Reprod, vol.87, p.148, 2012.

W. Robinson, D. Mcfadden, and M. Stephenson, The Origin of Abnormalities in Recurrent Aneuploidy/Polyploidy, The American Journal of Human Genetics, vol.69, issue.6, pp.1245-54, 2001.
DOI : 10.1086/324468

H. Kurahashi, H. Kogo, M. Tsutsumi, H. Inagaki, and T. Ohye, Failure of homologous synapsis and sex-specifi c reproduction problems, Front Genet, vol.3, p.112, 2012.

A. Musacchio and E. Salmon, The spindle-assembly checkpoint in space and time, Nature Reviews Molecular Cell Biology, vol.6, issue.5, pp.379-93, 2007.
DOI : 10.1038/nrm2163

A. Lopez-carrasco, S. Oltra, S. Monfort, S. Mayo, M. Rosello et al., Mutation screening of AURKB and SYCP3 in patients with reproductive problems, Molecular Human Reproduction, vol.19, issue.2, pp.102-110, 2013.
DOI : 10.1093/molehr/gas047

Q. Shi, M. Hu, M. Luo, Q. Liu, F. Jiang et al., Reduced expression of Mad2 and Bub1 proteins is associated with spontaneous miscarriages, Molecular Human Reproduction, vol.17, issue.1, pp.14-21, 2011.
DOI : 10.1093/molehr/gaq065

S. Nath, M. Moghe, A. Chowdhury, K. Godbole, G. Godbole et al., Is germline transmission of MAD2 gene deletion associated with human fetal loss?, Molecular Human Reproduction, vol.18, issue.11, pp.554-62, 2012.
DOI : 10.1093/molehr/gas031

S. Caburet, V. Arboleda, E. Llano, P. Overbeek, J. Barbero et al., Mutant Cohesin in Premature Ovarian Failure, New England Journal of Medicine, vol.370, issue.10, pp.943-952, 2014.
DOI : 10.1056/NEJMoa1309635
URL : https://hal.archives-ouvertes.fr/hal-00992209

G. Bridge, R. Monteiro, S. Henderson, V. Emuss, D. Lagos et al., The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis, Blood, vol.120, issue.25, pp.5063-72, 2012.
DOI : 10.1182/blood-2012-04-423004

S. Lyu, H. Song, J. Yoon, M. Chin, S. Sung et al., Transcriptional profiling with a pathway-oriented analysis in the placental villi of unexplained miscarriage, Placenta, vol.34, issue.2, pp.133-173, 2013.
DOI : 10.1016/j.placenta.2012.12.003

D. Easton, K. Pooley, A. Dunning, P. Pharoah, D. Thompson et al., Genome-wide association study identifies novel breast cancer susceptibility loci, Nature, vol.70, issue.7148, pp.1087-93, 2007.
DOI : 10.1038/nature05887

I. Kirkinezos and C. Moraes, Reactive oxygen species and mitochondrial diseases, Seminars in Cell & Developmental Biology, vol.12, issue.6, pp.449-57, 2001.
DOI : 10.1006/scdb.2001.0282

S. Gupta, A. Agarwal, J. Banerjee, and J. Alvarez, The Role of Oxidative Stress in Spontaneous Abortion and Recurrent Pregnancy Loss: A Systematic Review, Obstetrical & Gynecological Survey, vol.62, issue.5, pp.335-382, 2007.
DOI : 10.1097/01.ogx.0000261644.89300.df

E. Ruder, T. Hartman, and M. Goldman, Impact of oxidative stress on female fertility, Current Opinion in Obstetrics and Gynecology, vol.21, issue.3, pp.219-241, 2009.
DOI : 10.1097/GCO.0b013e32832924ba

M. Khadzhieva, N. Lutcenko, I. Volodin, K. Morozova, and L. Salnikova, Association of oxidative stress-related genes with idiopathic recurrent miscarriage, Free Radical Research, vol.731, issue.5, pp.534-575, 2014.
DOI : 10.3109/14767058.2012.733766

J. Tarry-adkins, M. Martin-gronert, D. Fernandez-twinn, I. Hargreaves, M. Alfaradhi et al., Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart, The FASEB Journal, vol.27, issue.1, pp.379-90, 2013.
DOI : 10.1096/fj.12-218685

T. Cotechini, M. Komisarenko, A. Sperou, S. Macdonald-goodfellow, M. Adams et al., Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia, The Journal of Experimental Medicine, vol.5, issue.1, pp.165-79, 2014.
DOI : 10.1007/s00011-012-0507-x

L. Myatt, Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta, Placenta, vol.31, pp.66-75, 2010.
DOI : 10.1016/j.placenta.2009.12.021

M. Su, S. Lin, and Y. Chen, Genetic association studies of angiogenesis- and vasoconstriction-related genes in women with recurrent pregnancy loss: a systematic review and meta-analysis, Human Reproduction Update, vol.17, issue.6
DOI : 10.1093/humupd/dmr027

C. Tempfer, G. Unfried, R. Zeillinger, L. Hefl-er, F. Nagele et al., Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage, Human Reproduction, vol.16, issue.8, pp.1644-1651, 2001.
DOI : 10.1093/humrep/16.8.1644

V. Suryanarayana, L. Rao, M. Kanakavalli, V. Padmalatha, M. Deenadayal et al., Recurrent early pregnancy loss and endothelial nitric oxide synthase gene polymorphisms, Archives of Gynecology and Obstetrics, vol.17, issue.1, pp.119-143, 2006.
DOI : 10.1007/s00404-005-0107-x

W. Fan, S. Li, and Y. Wang, Association of genetic polymorphisms in endothelial nitric oxide synthase 3 gene with recurrent early spontaneous abortion, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, vol.24, pp.23-29, 2007.

S. Shin, H. Lee, S. Cha, J. Kim, S. Shim et al., Endothelial nitric oxide synthase gene polymorphisms (???786T>C, 4a4b, 894G>T) and haplotypes in Korean patients with recurrent spontaneous abortion, European Journal of Obstetrics & Gynecology and Reproductive Biology, vol.152, issue.1, pp.64-71, 2010.
DOI : 10.1016/j.ejogrb.2010.05.014

F. Parveen, R. Faridi, V. Das, G. Tripathi, and S. Agrawal, Genetic association of phase I and phase II detoxification genes with recurrent miscarriages among North Indian women, Molecular Human Reproduction, vol.16, issue.3, pp.207-221, 2009.
DOI : 10.1093/molehr/gap096

L. Hefl-er, C. Tempfer, M. Bashford, G. Unfried, R. Zeillinger et al., Polymorphisms of the angiotensinogen gene, the endothelial nitric oxide synthase gene, and the interleukin-1beta gene promoter in women with idiopathic recurrent miscarriage, Molecular Human Reproduction, vol.8, issue.1, pp.95-100, 2002.
DOI : 10.1093/molehr/8.1.95

T. Buchholz, P. Lohse, E. Kosian, and C. Thaler, Vasoconstrictively Acting AT1R A1166C and NOS3 4/5 Polymorphisms in Recurrent Spontaneous Abortions (RSA)*, American Journal of Reproductive Immunology, vol.5, issue.5, pp.323-331, 2004.
DOI : 10.1126/science.274.5289.995

A. Makino, T. Nakanishi, M. Sugiura-ogasawara, Y. Ozaki, N. Suzumori et al., No Association of C677T Methylenetetrahydrofolate Reductase and an Endothelial Nitric Oxide Synthase Polymorphism with Recurrent Pregnancy Loss, American Journal of Reproductive Immunology, vol.61, issue.1, pp.60-66, 2004.
DOI : 10.1159/000016347

W. Zammiti, N. Mtiraoui, and T. Mahjoub, Lack of consistent association between endothelial nitric oxide synthase gene polymorphisms, homocysteine levels and recurrent pregnancy loss in tunisian women

M. Karvela, S. Papadopoulou, E. Tsaliki, E. Konstantakou, A. Hatzaki et al., Endothelial nitric oxide synthase gene polymorphisms in recurrent spontaneous abortions, Archives of Gynecology and Obstetrics, vol.97, issue.4, pp.349-52, 2008.
DOI : 10.1007/s00404-008-0577-8

M. Munafo and J. Flint, Meta-analysis of genetic association studies, Trends in Genetics, vol.20, issue.9, pp.439-483, 2004.
DOI : 10.1016/j.tig.2004.06.014

E. Bonney and P. Matzinger, The maternal immune system's interaction with circulating fetal cells, J Immunol, vol.158, pp.40-47, 1997.

G. Chaouat, Inflammation, NK cells and implantation: friend and foe (the good, the bad and the ugly?): replacing placental viviparity in an evolutionary perspective, Journal of Reproductive Immunology, vol.97, issue.1, pp.2-13, 2013.
DOI : 10.1016/j.jri.2012.10.009

T. Gill and . Rd, Role of the Major Histocompatibility Complex Region in Reproduction, Cancer, and Autoimmunity, American Journal of Reproductive Immunology, vol.165, issue.3, pp.211-216, 1996.
DOI : 10.1111/j.1600-0897.1996.tb00033.x

C. Coulam, B. Kaider, A. Kaider, P. Janowicz, and R. Roussev, Antiphospholipid antibodies associated with implantation failure after IVF/ET, Journal of Assisted Reproduction and Genetics, vol.14, issue.10, pp.603-611, 1997.
DOI : 10.1023/A:1022588903620

H. Carp, C. Selmi, and Y. Shoenfeld, The autoimmune bases of infertility and pregnancy loss, Journal of Autoimmunity, vol.38, issue.2-3, pp.266-274, 2012.
DOI : 10.1016/j.jaut.2011.11.016

Y. Shoenfeld, H. Carp, V. Molina, M. Blank, R. Cervera et al., Autoantibodies and Prediction of Reproductive Failure, American Journal of Reproductive Immunology, vol.10, issue.8387, pp.337-381, 2006.
DOI : 10.1016/S0029-7844(01)01646-5

A. Moravej, M. Jeddi-tehrani, A. Salek-moghaddam, P. Dokouhaki, R. Ghods et al., Evaluation of thyroglobulin expression in murine reproductive organs during pregnancy, American Journal of Reproductive Immunology, vol.1, pp.97-103, 2010.
DOI : 10.1111/j.1600-0897.2010.00827.x

J. Salmon, C. Heuser, M. Triebwasser, M. Liszewski, D. Kavanagh et al., Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort, PLoS Medicine, vol.143, issue.3, p.1001013, 2011.
DOI : 10.1371/journal.pmed.1001013.t003

G. Girardi, D. Yarilin, J. Thurman, V. Holers, and J. Salmon, Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction, The Journal of Experimental Medicine, vol.80, issue.9, pp.2165-75, 2006.
DOI : 10.1038/383086a0

G. Galazios, D. Papazoglou, P. Tsikouras, and G. Kolios, Vascular endothelial growth factor gene polymorphisms and pregnancy, The Journal of Maternal-Fetal & Neonatal Medicine, vol.16, issue.1
DOI : 10.1093/humupd/8.5.463

S. Bouvier, E. Cochery-nouvellon, G. Lavigne-lissalde, E. Mercier, P. Fabbro-peray et al., Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study, Blood, vol.123, issue.3, pp.414-435, 2014.
DOI : 10.1182/blood-2013-09-525014

C. Fang, V. Fremeaux-bacchi, M. Liszewski, G. Pianetti, M. Noris et al., Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome, Blood, vol.111, issue.2, pp.624-656, 2008.
DOI : 10.1182/blood-2007-04-084533

J. Risk, B. Flanagan, and P. Johnson, Polymorphism of the human CD46 gene in normal individuals and in recurrent spontaneous abortion, Human Immunology, vol.30, issue.3, pp.162-169, 1991.
DOI : 10.1016/0198-8859(91)90030-D

T. Laitinen, M. Lokki, M. Tulppala, O. Ylikorkala, and S. Koskimies, Tumour Necrosis Factor B Gene Polymorphism in Relation to Complotype in Couples with Spontaneous Abortions and in Control Families, Scandinavian Journal of Immunology, vol.33, issue.2, pp.131-136, 1992.
DOI : 10.1084/jem.135.1.68

N. Zutshi, M. Gandhi, and P. Kaul, CD46 polymorphism: A probable risk factor for recurrent spontaneous abortion in a northern Indian population, Natl Med J India, vol.23, pp.85-92, 2010.

F. Mohlin, E. Mercier, V. Fremeaux-bacchi, M. Liszewski, J. Atkinson et al., Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss, European Journal of Immunology, vol.69, issue.6, pp.1617-1646, 2013.
DOI : 10.1002/eji.201243196

J. Dausset, The major histocompatibility complex in man, Science, vol.213, issue.4515, pp.1469-74, 1981.
DOI : 10.1126/science.6792704

W. Faulk, A. Sanderson, and A. Temple, Distribution of MHC antigens in human placental chorionic villi, Transplant Proc, vol.9, pp.1379-84, 1977.

J. Hunt and H. Orr, HLA and maternal-fetal recognition, FASEB J, vol.6, pp.2344-2352, 1992.

C. Redman, J. Bodmer, W. Bodmer, L. Beilin, and J. Bonnar, HLA antigens in severe pre-eclampsia, Lancet, vol.2, pp.397-406, 1978.

K. Takakuwa, M. Higashino, H. Ueda, K. Yamada, K. Asano et al., Significant Compatibility Does Not Exist at the HLA-DQB Gene Locus in Couples With Unexplained Recurrent Abortions, American Journal of Reproductive Immunology, vol.141, issue.1, pp.12-18, 1992.
DOI : 10.1111/j.1600-0897.1992.tb00750.x

I. Hataya, K. Takakuwa, and K. Tanaka, Human leukocyte antigen class II genotype in patients with recurrent fetal miscarriage who are positive for anticardiolipin antibody, Fertility and Sterility, vol.70, issue.5, pp.919-942, 1998.
DOI : 10.1016/S0015-0282(98)00314-8

K. Takakuwa, I. Hataya, M. Arakawa, A. Kikuchi, M. Higashino et al., Possible Susceptibility of the HLA-DPB1*0402 and HLA-DPB1*04 Alleles to Unexplained Recurrent Abortion: Analysis by means of Polymerase Chain Reaction-Restricted Fragment Length Polymorphism Method, American Journal of Reproductive Immunology, vol.313, issue.4, pp.233-242, 1999.
DOI : 10.1111/j.1600-0897.1999.tb00096.x

K. Takakuwa, H. Adachi, I. Hataya, K. Ishii, M. Tamura et al., Molecular genetic studies of HLA-DRB1 alleles in patients with unexplained recurrent abortion in the Japanese population, Human Reproduction, vol.18, issue.4, pp.728-761, 2003.
DOI : 10.1093/humrep/deg188

P. Sagot, J. Bignon, A. Cesbron, M. Cheneau, G. Boog et al., Lack of evidence for a role of HLA-DP in unexplained recurrent spontaneous abortion, Transfusion Clinique et Biologique, vol.2, issue.3, pp.145-50, 1995.
DOI : 10.1016/S1246-7820(05)80041-2

O. Christiansen, O. Mathiesen, M. Husth, C. Jersild, and N. Grunnet, Studies of RFLP-inferred HLA-DR-DQ haplotypes in Danish women with recurrent fetal losses, Tissue Antigens, vol.30, issue.3, pp.134-143, 1992.
DOI : 10.1111/j.1399-0039.1992.tb02105.x

O. Christiansen, K. Rasmussen, C. Jersild, and N. Grunnet, HLA class II alleles confer susceptibility to recurrent fetal losses in Danish women, Tissue Antigens, vol.13, issue.4, pp.225-258, 1994.
DOI : 10.1111/j.1399-0039.1994.tb02387.x

C. Kruse, R. Steffensen, K. Varming, and O. Christiansen, A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage, Human Reproduction, vol.19, issue.5, pp.1215-1236, 2004.
DOI : 10.1093/humrep/deh200

T. Laitinen, S. Koskimies, and P. Westman, FOETO-MATERNAL COMPATIBILITY IN HLA-DR, -DQ, AND -DP LOCI IN FINNISH COUPLES SUFFERING FROM RECURRENT SPONTANEOUS ABORTIONS, European Journal of Immunogenetics, vol.38, issue.4, pp.249-58, 1993.
DOI : 10.1073/pnas.89.2.773

Q. Lin, P. Lu, and X. Wang, Study on human leucocyte antigen-DQ region gene polymorphism in cases of habitual abortion with anticardiolipin antibody, Zhonghua Fu Chan Ke Za Zhi, vol.35, pp.208-219, 2000.

X. Wang, Q. Lin, P. Lu, Z. Ma, and A. Zhao, Association of HLA-DQB1 coding region with unexplained recurrent spontaneous abortion, Chin Med J (Engl), vol.117, pp.492-499, 2004.

M. Zheng and L. Niu, Association of soluble human leukocyte antigen DQB1 with recurrent spontaneous abortion, Zhonghua Fu Chan Ke Za Zhi, vol.41, pp.152-156, 2006.

E. Bompeixe, C. Santos, P. Vargas, R. Von-linsingen, R. Zeck et al., HLA class II polymorphisms and recurrent spontaneous abortion in a Southern Brazilian cohort, International Journal of Immunogenetics, vol.40, issue.3, pp.186-91, 2012.
DOI : 10.1111/j.1744-313X.2012.01155.x

A. Gonzalez, V. Rebmann, J. Lemaoult, P. Horn, E. Carosella et al., The immunosuppressive molecule HLA-G and its clinical implications, Critical Reviews in Clinical Laboratory Sciences, vol.78, issue.1, pp.63-84, 2012.
DOI : 10.1007/s00428-005-0144-7

P. Hsu, B. Santner-nanan, J. Dahlstrom, M. Fadia, A. Chandra et al., Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia, The American Journal of Pathology, vol.181, issue.6, pp.2149-60, 2012.
DOI : 10.1016/j.ajpath.2012.08.032

I. Nowak, A. Malinowski, H. Tchorzewski, E. Barcz, J. Wilczynski et al., HLA-C C1C2 heterozygosity may protect women bearing the killer immunoglobulin-like receptor AA genotype from spontaneous abortion, Journal of Reproductive Immunology, vol.88, issue.1, pp.32-39, 2012.
DOI : 10.1016/j.jri.2010.11.001

S. Hiby, J. Walker, O. Shaughnessy, K. Redman, C. Carrington et al., Combinations of maternal KIR and fetal HLA-C genes infl uence the risk of preeclampsia and reproductive success

D. Kotze and T. Kruger, HLA-G as a marker for embryo selection in assisted reproductive technology, Fertility and Sterility, vol.100, issue.6, p.44, 2013.
DOI : 10.1016/j.fertnstert.2013.10.014

J. Karhukorpi, T. Laitinen, and A. Tiilikainen, HLA-G polymorphism in Finnish couples with recurrent spontaneous miscarriage, BJOG: An International Journal of Obstetrics and Gynaecology, vol.170, issue.10, pp.1212-1216, 1997.
DOI : 10.1016/0198-8859(96)85493-0

T. Yamashita, T. Fujii, K. Tokunaga, K. Tadokoro, Y. Hamai et al., Analysis of Human Leukocyte Antigen-G Polymorphism Including Intron 4 in Japanese Couples with Habitual Abortion, American Journal of Reproductive Immunology, vol.104, issue.2, pp.159-63, 1999.
DOI : 10.1111/j.1600-0897.1999.tb00089.x

T. Hviid, O. Christiansen, J. Johansen, U. Hviid, C. Lundegaard et al., Characterization of a new HLA-G allele encoding a nonconservative amino acid substitution in the ??3 domain (exon 4) and its relevance to certain complications in pregnancy, Immunogenetics, vol.53, issue.1, pp.48-53, 2001.
DOI : 10.1007/s002510100296

C. Aldrich, M. Stephenson, T. Karrison, R. Odem, D. Branch et al., HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage, Molecular Human Reproduction, vol.7, issue.12, pp.1167-72, 2001.
DOI : 10.1093/molehr/7.12.1167

T. Hviid, S. Hylenius, A. Hoegh, C. Kruse, and O. Christiansen, HLA-G polymorphisms in couples with recurrent spontaneous abortions, Tissue Antigens, vol.84, issue.2, pp.122-154, 2002.
DOI : 10.1101/gr.10.12.1968

T. Hviid, S. Hylenius, A. Lindhard, and O. Christiansen, Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome, Tissue Antigens, vol.58, issue.1, pp.66-75, 2004.
DOI : 10.1093/intimm/11.5.803

P. Tripathi, A. Abbas, S. Naik, and S. Agrawal, gene in the maintenance of pregnancy, Tissue Antigens, vol.156, issue.6, pp.706-716, 2004.
DOI : 10.1111/j.1399-0039.2004.00308.x

T. Kano, T. Mori, M. Furudono, H. Ishikawa, H. Watanabe et al., Human Leukocyte Antigen May Predict Outcome of Primary Recurrent Spontaneous Abortion Treated with Paternal Lymphocyte Alloimmunization Therapy, American Journal of Reproductive Immunology, vol.67, issue.4, pp.383-390, 2007.
DOI : 10.1111/j.1399-0039.2006.00723.x

W. Yan, L. Fan, J. Yang, L. Xu, Y. Ge et al., HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion, International Journal of Immunogenetics, vol.41, issue.1, pp.55-63, 2006.
DOI : 10.1034/j.1399-0039.2001.057001015.x

W. Yan, A. Lin, X. Chen, M. Dai, L. Gan et al., Association of the maternal 14-bp insertion polymorphism in the HLA-G gene in women with recurrent spontaneous abortions, Tissue Antigens, vol.16, issue.6, pp.521-524, 2006.
DOI : 10.1016/S0198-8859(00)00123-3

O. Sipak-szmigiel, C. Cybulski, J. Lubinski, and E. Ronin-walknowska, HLA-G polymorphism in a Polish population and reproductive failure, Tissue Antigens, vol.41, issue.0, pp.67-71, 2008.
DOI : 10.1111/j.1399-0039.2006.763_7.x

O. Sipak-szmigiel, C. Cybulski, D. Wokolorczyk, J. Lubinski, R. Kurzawa et al., fertilization failure in a Polish population, Tissue Antigens, vol.64, issue.Suppl 1, pp.348-52, 2009.
DOI : 10.1111/j.1399-0039.2008.01205.x

M. Aruna, P. Sirisha, A. Bhaskar, S. Tarakeswari, S. Thangaraj et al., Role of 14-bp insertion/deletion polymorphism in HLA-G among Indian women with recurrent spontaneous abortions, Tissue Antigens, vol.71, issue.2, pp.131-136, 2011.
DOI : 10.1111/j.1399-0039.2010.01584.x

R. Jassem, W. Shani, D. Loisel, M. Sharief, C. Billstrand et al., HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq, Human Immunology, vol.73, issue.8, pp.811-818, 2012.
DOI : 10.1016/j.humimm.2012.05.009

S. Xue, Y. J. Yao, F. Xu, L. Fan, and L. , Recurrent spontaneous abortions patients have more ???14 bp/+14 bp heterozygotes in the 3???UT region of the HLA-G gene in a Chinese Han population, Tissue Antigens, vol.64, issue.1, pp.153-158, 2007.
DOI : 10.1111/j.1399-0039.2006.763_7.x

X. Wang, W. Jiang, and D. Zhang, gene with unexplained recurrent spontaneous abortion: a meta-analysis, Tissue Antigens, vol.20, issue.Suppl 1, pp.108-123, 2013.
DOI : 10.1111/tan.12056

V. Suryanarayana, L. Rao, M. Kanakavalli, V. Padmalatha, T. Raseswari et al., Association Between Novel HLA-G Genotypes and Risk of Recurrent Miscarriages: A Case-Control Study in a South Indian Population, Reproductive Sciences, vol.15, issue.8, pp.817-841, 2008.
DOI : 10.1177/1933719107314061

A. Kolte, R. Steffensen, H. Nielsen, T. Hviid, and O. Christiansen, Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, and HLA-G-DRB1 haplotypes in families with recurrent miscarriage, Human Immunology, vol.71, issue.5, pp.482-490, 2010.
DOI : 10.1016/j.humimm.2010.02.001

D. Berger, W. Hogge, M. Barmada, and R. Ferrell, Comprehensive Analysis of HLA-G: Implications for Recurrent Spontaneous Abortion, Reproductive Sciences, vol.17, issue.4, pp.331-339, 2010.
DOI : 10.1177/1933719109356802

R. Vargas, P. Sarturi, S. Mattar, E. Bompeixe, S. Jdos et al., Association of HLA-G alleles and 3??? UTR 14 bp haplotypes with recurrent miscarriage in Brazilian couples, Human Immunology, vol.72, issue.6, pp.479-85, 2011.
DOI : 10.1016/j.humimm.2011.02.011

O. Christiansen, A. Kolte, M. Dahl, E. Larsen, R. Steffensen et al., Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients, Human Immunology, vol.73, issue.7, pp.699-705, 2012.
DOI : 10.1016/j.humimm.2012.04.014

C. Ober, C. Aldrich, I. Chervoneva, C. Billstrand, F. Rahimov et al., Variation in the HLA-G Promoter Region Influences Miscarriage Rates, The American Journal of Human Genetics, vol.72, issue.6, pp.1425-1460, 2003.
DOI : 10.1086/375501

R. Calicchio, L. Doridot, F. Miralles, C. Mehats, and D. Vaiman, DNA Methylation, An Epigenetic Mode of Gene Expression Regulation in Reproductive Science, Current Pharmaceutical Design, vol.20, issue.11, pp.1726-50, 2014.
DOI : 10.2174/13816128113199990517

A. Akhter, R. Faridi, V. Das, A. Pandey, S. Naik et al., In vitro up-regulation of HLA-G using dexamethasone and hydrocortisone in first-trimester trophoblast cells of women experiencing recurrent miscarriage, Tissue Antigens, vol.3, issue.2, pp.126-161, 2012.
DOI : 10.1111/j.1399-0039.2012.01884.x

T. Hviid and O. Christiansen, Linkage Disequilibrium Between Human Leukocyte Antigen (HLA) Class II and HLA-G???Possible Implications for Human Reproduction and Autoimmune Disease, Human Immunology, vol.66, issue.6, pp.688-99, 2005.
DOI : 10.1016/j.humimm.2005.03.003

C. Witt, J. Goodridge, M. Gerbase-delima, S. Daher, and F. Christiansen, Maternal KIR repertoire is not associated with recurrent spontaneous abortion, Human Reproduction, vol.19, issue.11, pp.2653-2660, 2004.
DOI : 10.1093/humrep/deh483

J. Karhukorpi, T. Laitinen, R. Karttunen, and A. Tiilikainen, The functionally important IL-10 promoter polymorphism (-1082G->A) is not a major genetic regulator in recurrent spontaneous abortions, Molecular Human Reproduction, vol.7, issue.2, pp.201-204, 2001.
DOI : 10.1093/molehr/7.2.201

W. Zammiti, N. Mtiraoui, E. Cochery-nouvellon, T. Mahjoub, W. Almawi et al., Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with idiopathic recurrent spontaneous abortion, Molecular Human Reproduction, vol.12, issue.12, pp.771-777, 2006.
DOI : 10.1093/molehr/gal084

G. Unfried, S. Bocskor, G. Endler, F. Nagele, J. Huber et al., A polymorphism of the interleukin-6 gene promoter and idiopathic recurrent miscarriage, Human Reproduction, vol.18, issue.2, pp.267-70, 2003.
DOI : 10.1093/humrep/deg094

Y. Saijo, F. Sata, H. Yamada, T. Kondo, E. Kato et al., Single nucleotide polymorphisms in the promoter

X. Ma, L. Xu, J. Wang, M. Xian, and M. Liu, Association of IL-1?? and IL-6 gene polymorphisms with recurrent spontaneous abortion in a Chinese Han population, International Journal of Immunogenetics, vol.11, issue.1, pp.15-24, 2011.
DOI : 10.1111/j.1744-313X.2011.01049.x

G. Unfried, C. Tempfer, C. Schneeberger, B. Widmar, F. Nagele et al., Interleukin 1 receptor antagonist polymorphism in women with idiopathic recurrent miscarriage, Fertility and Sterility, vol.75, issue.4, pp.683-690, 2001.
DOI : 10.1016/S0015-0282(01)01675-2

J. Karhukorpi, T. Laitinen, H. Kivela, A. Tiilikainen, and M. Hurme, IL-1 receptor antagonist gene polymorphism in recurrent spontaneous abortion, Journal of Reproductive Immunology, vol.58, issue.1, pp.61-68, 2003.
DOI : 10.1016/S0165-0378(02)00044-X

S. Linjawi, T. Li, S. Laird, and A. Blakemore, Interleukin-1 receptor antagonist and interleukin-1 beta polymorphisms in women with recurrent miscarriage, Fertility and Sterility, vol.83, issue.5, pp.1549-52, 2005.
DOI : 10.1016/j.fertnstert.2004.10.052

S. Levrant, C. Coulam, and R. Jeyendran, ORIGINAL ARTICLE: Interleukin 1 Receptor Antagonist Gene Polymorphisms Are Not Risk Factors for Recurrent Pregnancy Loss: Evaluation of Couples, American Journal of Reproductive Immunology, vol.12, issue.3, pp.224-232, 2008.
DOI : 10.1111/j.1600-0897.2008.00617.x

M. Dai, Y. Pan, D. Xu, X. Chen, R. Qian et al., IL-1 receptor antagonist gene polymorphism in idiopathic recurrent spontaneous abortion in a Chinese Han population, International Journal of Immunogenetics, vol.189, issue.5, pp.393-399, 2010.
DOI : 10.1111/j.1744-313X.2010.00939.x

E. Traina, S. Daher, A. Moron, S. Sun, C. Franchim et al., Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion, Journal of Reproductive Immunology, vol.88, issue.1, pp.53-60, 2010.
DOI : 10.1016/j.jri.2010.07.006

Y. Saijo, F. Sata, H. Yamada, T. Konodo, E. Kato et al., Interleukin-4 Gene Polymorphism is not Involved in the Risk of Recurrent Pregnancy Loss, American Journal of Reproductive Immunology, vol.45, issue.2, pp.143-149, 2004.
DOI : 10.1093/humrep/deh159

J. Reid, N. Simpson, R. Walker, O. Economidou, J. Shillito et al., The Carriage of Pro-Inflammatory Cytokine Gene Polymorphisms in Recurrent Pregnancy Loss, American Journal of Reproductive Immunology, vol.45, issue.1, pp.35-40, 2001.
DOI : 10.1111/j.8755-8920.2001.450106.x

L. Hefl-er, C. Tempfer, G. Unfried, C. Schneeberger, K. Lessl et al., A polymorphism of the interleukin-1?? gene and idiopathic recurrent miscarriage, Fertility and Sterility, vol.76, issue.2, pp.377-386, 2001.
DOI : 10.1016/S0015-0282(01)01914-8

Z. Wang, E. Yunis, M. De-los-santos, L. Xiao, D. Anderson et al., T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region, Genes and Immunity, vol.3, issue.1, pp.38-42, 2002.
DOI : 10.1038/sj.gene.6363812

S. Babbage, P. Arkwright, G. Vince, C. Perrey, V. Pravica et al., Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss, Journal of Reproductive Immunology, vol.51, issue.1, pp.21-28, 2001.
DOI : 10.1016/S0165-0378(01)00069-9

A. Alkhuriji, A. Alhimaidi, Z. Babay, and A. Wary, The relationship between cytokine gene polymorphism and unexplained recurrent spontaneous abortion in Saudi females, Saudi Med J, vol.34, pp.484-493, 2013.

S. Messaoudi, G. Khateeb, M. Dendana, M. Sater, K. Jazia et al., Genetic variations in the interleukin-21 gene and the risk of recurrent idiopathic spontaneous miscarriage, Eur Cytokine Netw, vol.22, pp.123-129, 2011.

L. Bouteiller, P. Tabiasco, and J. , Killers become builders during pregnancy, Nature Medicine, vol.329, issue.9, pp.991-993, 2006.
DOI : 10.1038/nm0906-991

J. Hanna, D. Goldman-wohl, Y. Hamani, I. Avraham, C. Greenfi-eld et al., Decidual NK cells regulate key developmental processes at the human fetal-maternal interface, Nature Medicine, vol.4, issue.9, pp.1065-74, 2006.
DOI : 10.1038/nm1452

S. Ostojic, M. Volk, I. Medica, M. Kapovic, H. Meden-vrtovec et al., Polymorphisms in the Interleukin-12/18 Genes and Recurrent Spontaneous Abortion, American Journal of Reproductive Immunology, vol.19, issue.5, pp.403-411, 2007.
DOI : 10.1084/jem.194.2.143

G. Al-khateeb, M. Sater, R. Finan, F. Mustafa, A. Busaidi et al., Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage, Fertility and Sterility, vol.96, issue.4, pp.921-927, 2011.
DOI : 10.1016/j.fertnstert.2011.06.079

S. Messaoudi, M. Dandana, K. Magdoud, S. Meddeb, B. Slama et al., Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population, Journal of Reproductive Immunology, vol.93, issue.2, pp.109-122, 2012.
DOI : 10.1016/j.jri.2011.12.002

S. Bombell and W. Mcguire, Cytokine polymorphisms in women with recurrent pregnancy loss: Meta-analysis, The Australian and New Zealand Journal of Obstetrics and Gynaecology, vol.142, issue.2, pp.147-54, 2008.
DOI : 10.1016/j.ajog.2004.01.001

I. Medica, S. Ostojic, N. Pereza, A. Kastrin, and B. Peterlin, Association between genetic polymorphisms in cytokine genes and recurrent miscarriage ??? a meta-analysis, Reproductive BioMedicine Online, vol.19, issue.3, pp.406-420, 2009.
DOI : 10.1016/S1472-6483(10)60176-9

S. Agrawal, F. Parveen, R. Faridi, and S. Prakash, Interleukin-1 gene cluster variants and recurrent pregnancy loss among North Indian women: retrospective study and meta-analysis, Reproductive BioMedicine Online, vol.24, issue.3, pp.342-51, 2012.
DOI : 10.1016/j.rbmo.2011.11.021

B. Sibai, Thrombophilia and Severe Preeclampsia: Time to Screen and Treat in Future Pregnancies?, Hypertension, vol.46, issue.6, pp.1252-1255, 2005.
DOI : 10.1161/01.HYP.0000188904.47575.7e

C. Redman and I. Sargent, Latest Advances in Understanding Preeclampsia, Science, vol.308, issue.5728, pp.1592-1596, 2005.
DOI : 10.1126/science.1111726

W. Davenport and W. Kutteh, Inherited Thrombophilias and Adverse Pregnancy Outcomes, Obstetrics and Gynecology Clinics of North America, vol.41, issue.1, pp.133-177, 2014.
DOI : 10.1016/j.ogc.2013.10.005

Z. Wang, P. Wang, X. Wang, X. He, D. Xu et al., Significant association between angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of recurrent miscarriage: A systematic review and meta-analysis, Metabolism, vol.62, issue.9, pp.1227-1265, 2013.
DOI : 10.1016/j.metabol.2013.03.003

Z. Rahimi, A. Aghaei, and A. Vaisi-raygani, AT2R ???1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9 ???1562 C:T polymorphisms: Risk factors for susceptibility to preeclampsia, Gene, vol.538, issue.1, pp.176-81, 2014.
DOI : 10.1016/j.gene.2013.12.013

I. Martinelli, E. Taioli, I. Cetin, A. Marinoni, S. Gerosa et al., Mutations in Coagulation Factors in Women with Unexplained Late Fetal Loss, New England Journal of Medicine, vol.343, issue.14, pp.1015-1023, 2000.
DOI : 10.1056/NEJM200010053431405

C. Napoli, J. Witztum, F. De-nigris, G. Palumbo, D. Armiento et al., Intracranial Arteries of Human Fetuses Are More Resistant to Hypercholesterolemia-Induced Fatty Streak Formation Than Extracranial Arteries, Circulation, vol.99, issue.15, pp.2003-2013, 1999.
DOI : 10.1161/01.CIR.99.15.2003

M. Jasper, K. Tremellen, and S. Robertson, Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue, Molecular Human Reproduction, vol.12, issue.5, pp.301-309, 2006.
DOI : 10.1093/molehr/gal032

E. Rey, S. Kahn, M. David, and I. Shrier, Thrombophilic disorders and fetal loss: a meta-analysis, The Lancet, vol.361, issue.9361, pp.901-909, 2003.
DOI : 10.1016/S0140-6736(03)12771-7

J. Cao, J. Cai, D. Huang, Q. Han, Q. Yang et al., miR-335 represents an invasion suppressor gene in ovarian cancer by targeting Bcl-w

E. Guerra-shinohara, J. Bertinato, T. Bueno, C. , C. Da-silva et al., Polymorphisms in antithrombin and in tissue factor pathway inhibitor genes are associated with recurrent pregnancy loss, Thrombosis and Haemostasis, vol.108, issue.4, pp.693-700, 2013.
DOI : 10.1160/TH12-03-0177

A. Kolte, H. Nielsen, I. Moltke, B. Degn, B. Pedersen et al., A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage, Molecular Human Reproduction, vol.17, issue.6, pp.379-85, 2011.
DOI : 10.1093/molehr/gar003

O. Christiansen, K. Riisom, J. Lauritsen, N. Grunnet, and C. Jersild, Association of maternal HLA haplotypes with recurrent spontaneous abortions, Tissue Antigens, vol.319, issue.suppl 52, pp.190-199, 1989.
DOI : 10.1111/j.1399-0039.1989.tb01736.x

L. Kluijtmans, J. Kastelein, J. Lindemans, G. Boers, S. Heil et al., Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease, Circulation, vol.96, issue.8, pp.2573-2580, 1997.
DOI : 10.1161/01.CIR.96.8.2573

W. Nelen, E. Van-der-molen, H. Blom, S. Heil, E. Steegers et al., Recurrent early pregnancy loss and genetic-related disturbances in folate and homocysteine metabolism, Br J Hosp Med, vol.58, pp.511-514, 1997.

E. Mercier, G. Lissalde-lavigne, and J. Gris, V617F Mutation in Unexplained Loss of First Pregnancy, New England Journal of Medicine, vol.357, issue.19, pp.1984-1989, 2007.
DOI : 10.1056/NEJMc071528

P. Laissue, G. Burgio, D. Hote, R. G. Marchiol-fournigault, C. Fradelizi et al., Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography, The International Journal of Developmental Biology, vol.53, issue.4, pp.623-632, 2009.
DOI : 10.1387/ijdb.082613pl
URL : https://hal.archives-ouvertes.fr/hal-01370041

M. Vatin, S. Bouvier, L. Bellazi, X. Montagutelli, P. Laissue et al., Polymorphisms of Human Placental Alkaline Phosphatase Are Associated with in??Vitro Fertilization Success and Recurrent Pregnancy Loss, The American Journal of Pathology, vol.184, issue.2, pp.362-370, 2014.
DOI : 10.1016/j.ajpath.2013.10.024

D. Cohen, A. Buurma, N. Goemaere, G. Girardi, S. Le-cessie et al., Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss, The Journal of Pathology, vol.174, issue.suppl A
DOI : 10.1002/path.2893

G. Girardi and J. Salmon, The Role of Complement in Pregnancy and Fetal Loss, Autoimmunity, vol.36, issue.1, pp.19-26, 2003.
DOI : 10.1080/0891693031000067322

X. Wu, D. Spitzer, D. Mao, S. Peng, H. Molina et al., Membrane Protein Crry Maintains Homeostasis of the Complement System, The Journal of Immunology, vol.181, issue.4
DOI : 10.4049/jimmunol.181.4.2732

S. Pedroni, J. Gonzalez, J. Wade, M. Jansen, A. Serio et al., Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1842, issue.1, pp.107-122, 2014.
DOI : 10.1016/j.bbadis.2013.10.011

A. Takeshita, K. Kusakabe, M. Hiyama, N. Kuniyoshi, T. Kondo et al., Dynamics and reproductive effects of complement factors in the spontaneous abortion model of CBA/J??DBA/2 mice, Immunobiology, vol.219, issue.5, pp.385-91, 2014.
DOI : 10.1016/j.imbio.2014.01.001