Skip to Main content Skip to Navigation
Journal articles

Notch inhibits yorkie activity in Drosophila wing discs.

Abstract : During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk between these pathways also pattern these discs to specify different regions with different fates and growth potentials. We show that the Notch signaling pathway is both required and sufficient to inhibit the activity of Yorkie (Yki), the Salvador/Warts/Hippo (SWH) pathway terminal transcription activator, but only in the central regions of the wing disc, where the TEAD factor and Yki partner Scalloped (Sd) is expressed. We show that this cross-talk between the Notch and SWH pathways is mediated, at least in part, by the Notch target and Sd partner Vestigial (Vg). We propose that, by altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs.
Document type :
Journal articles
Complete list of metadata
Contributor : Yves Le Ster Connect in order to contact the contributor
Submitted on : Wednesday, September 24, 2014 - 10:53:50 AM
Last modification on : Monday, October 11, 2021 - 1:23:32 PM
Long-term archiving on: : Thursday, December 25, 2014 - 10:30:42 AM


Publisher files allowed on an open archive



Alexandre Djiane, Sophie Zaessinger, Burcu Babaoğlan, Sarah Bray. Notch inhibits yorkie activity in Drosophila wing discs.. PLoS ONE, Public Library of Science, 2014, 9 (8), pp.e106211. ⟨10.1371/journal.pone.0106211⟩. ⟨inserm-01067825⟩



Les métriques sont temporairement indisponibles