Skip to Main content Skip to Navigation
Journal articles

Does machine perfusion decrease ischemia reperfusion injury?

Abstract : In 1990's, use of machine perfusion for organ preservation has been abandoned because of improvement of preservation solutions, efficient without perfusion, easy to use and cheaper. Since the last 15 years, a renewed interest for machine perfusion emerged based on studies performed on preclinical model and seems to make consensus in case of expanded criteria donors or deceased after cardiac death donations. We present relevant studies highlighted the efficiency of preservation with hypothermic machine perfusion compared to static cold storage. Machines for organ preservation being in constant evolution, we also summarized recent developments included direct oxygenation of the perfusat. Machine perfusion technology also enables organ reconditioning during the last hours of preservation through a short period of perfusion on hypothermia, subnormothermia or normothermia. We present significant or low advantages for machine perfusion against ischemia reperfusion injuries regarding at least one primary parameter: risk of DFG, organ function or graft survival.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-01057473
Contributor : Delphine Bon <>
Submitted on : Friday, August 22, 2014 - 3:49:08 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:04 AM

Identifiers

Collections

Citation

Delphine Bon, Pierre-Olivier Delpech, Nicolas Chatauret, Thierry Hauet, Lionel Badet, et al.. Does machine perfusion decrease ischemia reperfusion injury?. Progrès en Urologie, Elsevier Masson, 2014, 24 Suppl 1, pp.S44-50. ⟨10.1016/S1166-7087(14)70063-6⟩. ⟨inserm-01057473⟩

Share

Metrics

Record views

381