Skip to Main content Skip to Navigation
Journal articles

Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.

Abstract : Triglycerides in adipose tissue are rapidly mobilized during times of energy needs via lipolysis, a catabolic process that plays important role in whole body triglyceride turnover. Lipolysis is regulated through cell surface receptors via neurotransmitters, hormones, and paracrine factors that activate various intracellular pathways. These pathways converge on the lipid droplet, the site of action of lipases and cofactors. Fat cell lipolysis is also involved in the pathogenesis of metabolic disorders, and recent human studies have underscored its role in disease states such as cancer cachexia and obesity-induced insulin resistance. We highlight here topics and findings with physiological and clinical relevance, namely lipid turnover in human fat cells and the role of lipolysis in cancer cachexia and obesity-induced insulin resistance.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-01055325
Contributor : Marie Francoise Simon <>
Submitted on : Tuesday, August 12, 2014 - 2:39:46 PM
Last modification on : Friday, January 10, 2020 - 9:09:54 PM

Identifiers

Collections

Citation

Peter Arner, Dominique Langin. Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.. Trends Endocrinol Metab, 2014, 25 (5), pp.255-62. ⟨10.1016/j.tem.2014.03.002⟩. ⟨inserm-01055325⟩

Share

Metrics

Record views

173