First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.

Charlotte Rouzaud Laborde; Clément Delmas; Jeanne Mialet-Perez; Nathalie Pizzinat; Caroline Biendel-Picquet; Nicolas Boudou; Nicolas Dumonteil; Odile Spreux-Varoquaux; Didier Carrié; Michel Galinier; Angelo Parini; Olivier Lairez

doi:10.1155/2013/847069

First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.

Charlotte Rouzaud Laborde ^{1, 2} Clément Delmas ³ Jeanne Mialet-Perez ² Nathalie Pizzinat ² Caroline Biendel-Picquet ³ Nicolas Boudou ³ Nicolas Dumonteil ³ Odile Spreux-Varoquaux ⁴ Didier Carrié ^{3, 5} Michel Galinier ³ Angelo Parini ² Olivier Lairez ^{2, 3, 5, 6, *}

* Auteur correspondant

1 Service de Pharmacie

2 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires

3 Service de cardiologie [Toulouse]

4 Unité de Pharmacologie - Toxicologie

5 Centre d'Imagerie Cardiaque

6 Médecine nucléaire [Rangueil]

Abstract : BACKGROUND: There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and healthy control subjects (HCS). METHODS AND RESULTS: Plasma serotonin levels in 14 consecutive patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. Plasma serotonin levels at admission were markedly higher in patients with TTC and STEMI as compared to HCS (3.9 ± 4.6, P = 0.02 versus control; 5.7 ± 5.6, P = 0.001 versus control; and 1 ± 0.4 ng/mL, resp.). There was no difference in serotonin levels between patients with TTC and those with STEMI (P = 0.33). CONCLUSION: This finding suggests that serotonin could participate to the pathophysiology of TTC.

Type de document :

Article dans une revue

BioMed Research International , Hindawi Publishing Corporation, 2013, 2013, pp.847069. 〈10.1155/2013/847069〉

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http://www.hal.inserm.fr/inserm-01053501
Contributeur : Marie Francoise Simon <>
Soumis le : jeudi 31 juillet 2014 - 11:11:27
Dernière modification le : jeudi 4 octobre 2018 - 09:50:10

First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.

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First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.

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