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Journal articles
First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.
Charlotte Rouzaud Laborde
1, 2
Clément Delmas
3
Jeanne Mialet-Perez
2
Nathalie Pizzinat
2
Caroline Biendel-Picquet
3
Nicolas Boudou
3
Nicolas Dumonteil
3
Odile Spreux-Varoquaux
4
Didier Carrié
3, 5
Michel Galinier
3
Angelo Parini
2
Olivier Lairez
2, 3, 5, 6, *
Charlotte Rouzaud Laborde 1, 2
Author
Clément Delmas 3
Author
Jeanne Mialet-Perez 2
Author
Nathalie Pizzinat 2
Author
Caroline Biendel-Picquet 3
Author
Nicolas Boudou 3
Author
Nicolas Dumonteil 3
Author
Odile Spreux-Varoquaux 4
Author
Didier Carrié 3, 5
Author
Michel Galinier 3
Author
Angelo Parini 2
Author
Olivier Lairez 2, 3, 5, 6
Correspondent author
1
Service de Pharmacie (1, avenue du Pr Jean Poulhès - TSA 50032 - 31059 Toulouse Cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital de Rangueil (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
2
I2MC - Institut des Maladies Métaboliques et Cardiovasculaires (1 avenue du Prof Jean Poulhes - BP 84225 - 31432 Toulouse Cedex 4 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR1048 (101, rue de Tolbiac, 75013 Paris - France)
3
Service de cardiologie [Toulouse] (Pôle Cardiovasculaire et Métabolique, 1, avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse cedex 9 - France)
- Hôpital de Rangueil (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
4
CHV - Centre Hospitalier de Versailles André Mignot (Versailles, Trappes, Andrésy et Bois d'Arcy, Chesnay - France)
5
Centre d'Imagerie Cardiaque (1, avenue du Pr Jean Poulhès - TSA 50032 - 31059 Toulouse Cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital de Rangueil (France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
6
Service de Médecine Nucléaire [Toulouse] (Place du Docteur Baylac - TSA 40031 - 31059 Toulouse cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
Abstract : BACKGROUND: There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and healthy control subjects (HCS). METHODS AND RESULTS: Plasma serotonin levels in 14 consecutive patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. Plasma serotonin levels at admission were markedly higher in patients with TTC and STEMI as compared to HCS (3.9 ± 4.6, P = 0.02 versus control; 5.7 ± 5.6, P = 0.001 versus control; and 1 ± 0.4 ng/mL, resp.). There was no difference in serotonin levels between patients with TTC and those with STEMI (P = 0.33). CONCLUSION: This finding suggests that serotonin could participate to the pathophysiology of TTC.
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Journal articles
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https://www.hal.inserm.fr/inserm-01053501
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, July 31, 2014 - 11:11:27 AM
Last modification on : Tuesday, July 7, 2020 - 2:06:08 PM
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, July 31, 2014 - 11:11:27 AM
Last modification on : Tuesday, July 7, 2020 - 2:06:08 PM
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- HAL Id : inserm-01053501, version 1
- DOI : 10.1155/2013/847069
- PUBMED : 24175304
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Charlotte Rouzaud Laborde, Clément Delmas, Jeanne Mialet-Perez, Nathalie Pizzinat, Caroline Biendel-Picquet, et al.. First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.. BioMed Research International , Hindawi Publishing Corporation, 2013, 2013, pp.847069. ⟨10.1155/2013/847069⟩. ⟨inserm-01053501⟩
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