Skip to Main content Skip to Navigation
Journal articles

Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.

Abstract : BACKGROUND: We evaluated if plasma β-amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study. METHODS: Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators. RESULTS: A relationship between high plasma Aβ1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01-1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels. CONCLUSIONS: Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.
Document type :
Journal articles
Complete list of metadata

Cited literature [38 references]  Display  Hide  Download
Contributor : Claudine Berr Connect in order to contact the contributor
Submitted on : Wednesday, July 16, 2014 - 5:12:41 PM
Last modification on : Friday, August 5, 2022 - 10:42:17 AM
Long-term archiving on: : Monday, November 24, 2014 - 4:52:12 PM


Files produced by the author(s)



Audrey Gabelle, Susanna Schraen, Laure-Anne Gutierrez, Cecile Pays, Olivier Rouaud, et al.. Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.. Alzheimer's and Dementia, Elsevier, 2015, 11 (6), pp.672-80. ⟨10.1016/j.jalz.2014.04.515⟩. ⟨inserm-01024830⟩



Record views


Files downloads