Acute electromyostimulation decreases muscle sympathetic nerve activity in patients with advanced chronic heart failure (EMSICA Study).

Marc Labrunée 1, * Fabien Despas 2 Philippe Marque 3, 4 Thibaut Guiraud 5 Michel Galinier 3, 6 Jean Michel Senard 2 Atul Pathak 7
* Auteur correspondant
1 Equipe 8 Inserm U1048
I2MC - Institut des Maladies Métaboliques et Cardiovasculaires, Fédération Française de Cardiologie, Médecine Physique et de Réadaptation, Service de Pharmacologie Clinique
2 Equipe 8 Inserm U1048
I2MC - Institut des Maladies Métaboliques et Cardiovasculaires, Service de Pharmacologie Clinique
5 Equipe 8 Inserm U1048
I2MC - Institut des Maladies Métaboliques et Cardiovasculaires, Centre de Rééducation Cardiovasculaire et Pulmonaire [Clinique Saint Orens - Toulouse)
7 Equipe 8 Inserm U1048
I2MC - Institut des Maladies Métaboliques et Cardiovasculaires, Fédération Française de Cardiologie, Service de Pharmacologie Clinique
Abstract : BACKGROUND: Muscle passive contraction of lower limb by neuromuscular electrostimulation (NMES) is frequently used in chronic heart failure (CHF) patients but no data are available concerning its action on sympathetic activity. However, Transcutaneous Electrical Nerve Stimulation (TENS) is able to improve baroreflex in CHF. The primary aim of the present study was to investigate the acute effect of TENS and NMES compared to Sham stimulation on sympathetic overactivity as assessed by Muscle Sympathetic Nerve Activity (MSNA). METHODS: We performed a serie of two parallel, randomized, double blinded and sham controlled protocols in twenty-two CHF patients in New York Heart Association (NYHA) Class III. Half of them performed stimulation by TENS, and the others tested NMES. RESULTS: Compare to Sham stimulation, both TENS and NMES are able to reduce MSNA (63.5 ± 3.5 vs 69.7 ± 3.1 bursts / min, p < 0.01 after TENS and 51.6 ± 3.3 vs 56.7 ± 3.3 bursts / min, p < 0, 01 after NMES). No variation of blood pressure, heart rate or respiratory parameters was observed after stimulation. CONCLUSION: The results suggest that sensory stimulation of lower limbs by electrical device, either TENS or NMES, could inhibit sympathetic outflow directed to legs in CHF patients. These properties could benefits CHF patients and pave the way for a new non-pharmacological approach of CHF.
Type de document :
Article dans une revue
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e79438. 〈10.1371/journal.pone.0079438〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-01015931
Contributeur : Marie Francoise Simon <>
Soumis le : vendredi 27 juin 2014 - 14:32:04
Dernière modification le : jeudi 4 octobre 2018 - 09:50:10

Lien texte intégral

Identifiants

Collections

Citation

Marc Labrunée, Fabien Despas, Philippe Marque, Thibaut Guiraud, Michel Galinier, et al.. Acute electromyostimulation decreases muscle sympathetic nerve activity in patients with advanced chronic heart failure (EMSICA Study).. PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e79438. 〈10.1371/journal.pone.0079438〉. 〈inserm-01015931〉

Partager

Métriques

Consultations de la notice

51