Chronic Bickerstaff's encephalitis with cognitive impairment, a reality? - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles BMC Neurology Year : 2014

Chronic Bickerstaff's encephalitis with cognitive impairment, a reality?

Abstract

BACKGROUND: Bickerstaff's encephalitis (BE) is an acute post-infectious demyelinating disease with albuminocytological dissociation. A chronic form has rarely been described previously. CASE PRESENTATION: A 44-year-old man was hospitalized for drowsiness, cognitive complaint limb weakness, ataxia and sensory disturbance after diarrhea. Neuropsychological evaluation showed slowing, memory and executive function impairment, while analysis of the CSF showed albuminocytological dissociation. Immunologic tests showed positive anti-ganglioside antibodies (anti-GM1 IgM, anti-GD1a IgG and anti-GD1b IgM). Brain MRI was normal but SPECT showed bilateral temporal and frontal hypoperfusion. Outcome under immunoglobulin treatment (IVIG) was favorable with an initial improvement but was marked by worsening after a few weeks. Consequently, the patient was treated with IVIG every 2 months due to the recurrence of symptoms after 6 weeks. CONCLUSION: This case raises the question of the existence of a chronic form of BE with cognitive impairment, in the same way as chronic inflammatory demyelinating polyneuropathy is considered to be a chronic form of Guillain-Barré syndrome.
Fichier principal
Vignette du fichier
1471-2377-14-99.pdf (259.85 Ko) Télécharger le fichier
1471-2377-14-99.xml (37.17 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00998281 , version 1 (31-05-2014)

Identifiers

Cite

Mathilde Renaud, Jérôme Aupy, Guillaume Camuset, Nicolas Collongues, Jean-Baptiste Chanson, et al.. Chronic Bickerstaff's encephalitis with cognitive impairment, a reality?. BMC Neurology, 2014, 14 (1), pp.99. ⟨10.1186/1471-2377-14-99⟩. ⟨inserm-00998281⟩
290 View
234 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More