Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice.

Kazunari Nohara 1 Suhuan Liu 1 Matthew Meyers 1 Aurélie Waget 2 Mathieu Ferron 2 Gérard Karsenty 2 Rémy Burcelin 3 Franck Mauvais-Jarvis 1, 4, *
* Auteur correspondant
1 Division of Endocrinology, Metabolism and Molecular Medicine and Comprehensive Center on Obesity
2 Department of Genetics and Development
3 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
4 Division of Endocrinology
Abstract : Polycystic ovary syndrome is a common endocrine disorder in females of reproductive age and is believed to have a developmental origin in which gestational androgenization programs reproductive and metabolic abnormalities in offspring. During gestation, both male and female fetuses are exposed to potential androgen excess. In this study, we determined the consequences of developmental androgenization in male mice exposed to neonatal testosterone (NTM). Adult NTM displayed hypogonadotropic hypogonadism with decreased serum testosterone and gonadotropin concentrations. Hypothalamic KiSS1 neurons are believed to be critical to the onset of puberty and are the target of leptin. Adult NTM exhibited lower hypothalamic Kiss1 expression and a failure of leptin to upregulate Kiss1 expression. NTM displayed an early reduction in lean mass, decreased locomotor activity, and decreased energy expenditure. They displayed a delayed increase in subcutaneous white adipose tissue amounts. Thus, excessive neonatal androgenization disrupts reproduction and energy homeostasis and predisposes to hypogonadism and obesity in adult male mice.
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Journal of Endocrinology, BioScientifica, 2013, 219 (3), pp.259-68. 〈10.1530/JOE-13-0230〉
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http://www.hal.inserm.fr/inserm-00997962
Contributeur : Marie Francoise Simon <>
Soumis le : vendredi 30 mai 2014 - 07:57:51
Dernière modification le : jeudi 13 septembre 2018 - 10:50:02

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Kazunari Nohara, Suhuan Liu, Matthew Meyers, Aurélie Waget, Mathieu Ferron, et al.. Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice.. Journal of Endocrinology, BioScientifica, 2013, 219 (3), pp.259-68. 〈10.1530/JOE-13-0230〉. 〈inserm-00997962〉

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