Diagnosis of genital herpes simplex virus infection in the clinical laboratory. - Archive ouverte HAL Access content directly
Journal Articles Virology Journal Year : 2014

Diagnosis of genital herpes simplex virus infection in the clinical laboratory.

(1) , (2) , (2)
1
2

Abstract

Since the type of herpes simplex virus (HSV) infection affects prognosis and subsequent counseling, type-specific testing to distinguish HSV-1 from HSV-2 is always recommended. Although PCR has been the diagnostic standard method for HSV infections of the central nervous system, until now viral culture has been the test of choice for HSV genital infection. However, HSV PCR, with its consistently and substantially higher rate of HSV detection, could replace viral culture as the gold standard for the diagnosis of genital herpes in people with active mucocutaneous lesions, regardless of anatomic location or viral type. Alternatively, antigen detection-an immunofluorescence test or enzyme immunoassay from samples from symptomatic patients--could be employed, but HSV type determination is of importance. Type-specific serology based on glycoprotein G should be used for detecting asymptomatic individuals but widespread screening for HSV antibodies is not recommended. In conclusion, rapid and accurate laboratory diagnosis of HSV is now become a necessity, given the difficulty in making the clinical diagnosis of HSV, the growing worldwide prevalence of genital herpes and the availability of effective antiviral therapy.
Fichier principal
Vignette du fichier
1743-422X-11-83.pdf (266.31 Ko) Télécharger le fichier
Vignette du fichier
1743-422X-11-83.xml (155.92 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00995797 , version 1 (24-05-2014)

Identifiers

Cite

Jérôme Legoff, Hélène Péré, Laurent Bélec. Diagnosis of genital herpes simplex virus infection in the clinical laboratory.. Virology Journal, 2014, 11 (1), pp.83. ⟨10.1186/1743-422X-11-83⟩. ⟨inserm-00995797⟩
350 View
1176 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More