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Journal Articles News in Physiological Sciences Year : 2014

GLP-1-based strategies: a physiological analysis of differential mode of action.

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Abstract

DPP4 inhibitors and GLP-1 receptor agonists used in incretin-based strategies treat Type 2 diabetes with different modes of action. The pharmacological blood GLP-1R agonist concentration targets pancreatic and some extrapancreatic GLP-1R, whereas DPP4i favors the physiological activation of the gut-brain-periphery axis that could allow clinicians to adapt the management of Type 2 diabetes, according to the patient's pathophysiological characteristics.
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Dates and versions

inserm-00995704 , version 1 (23-05-2014)

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Rémy Burcelin, Pierre Gourdy, Stéphane Dalle. GLP-1-based strategies: a physiological analysis of differential mode of action.. News in Physiological Sciences, 2014, 29 (2), pp.108-21. ⟨10.1152/physiol.00009.2013⟩. ⟨inserm-00995704⟩
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