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Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein.

Abstract : BACKGROUND: Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly altered kidney function was to evaluate levels of inactive, dephospho-uncarboxylated MGP(dp-ucMGP) and total uncarboxylated MGP(t-ucMGP) and assess their links with biological and clinical parameters (including peripheral vascular calcification). METHODS: The DIACART study is a cross-sectional cohort study of 198 patients with type 2 diabetes and normal or slightly altered kidney function. Matrix Gla protein levels were measured with an ELISA and all patients underwent multislice spiral computed tomography scans to score below-knee arterial calcification. RESULTS: In the study population as a whole, the mean dp-ucMGP and t-ucMGP levels were 627 +/- 451 pM and 4868 +/- 1613 nM, respectively. Glomerular filtration rate, age and current vitamin K antagonist use were independently associated with dp-ucMGP levels. When the study population was divided according to the median peripheral arterial calcification score, patients with the higher score displayed significantly lower t-ucMGP and significantly higher dp-ucMGP levels. Furthermore, plasma dp-ucMGP was positively associated with the peripheral arterial calcification score (independently of age, gender, previous cardiovascular disease and t-ucMGP levels). CONCLUSIONS: High dp-ucMGP levels were independently associated with below-knee arterial calcification score in patients with type 2 diabetes and normal or slightly altered kidney function. The reversibility of the elevation of dp-ucMGP levels and the latter's relationship with clinical events merit further investigation.
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Submitted on : Monday, May 12, 2014 - 9:05:42 AM
Last modification on : Friday, October 23, 2020 - 4:51:13 PM
Long-term archiving on: : Tuesday, August 12, 2014 - 11:10:21 AM

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Sophie Liabeuf, Bourron Olivier, Cees Vemeer, Elke Theuwissen, Elke Magdeleyns, et al.. Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein.. Cardiovascular Diabetology, BioMed Central, 2014, 13 (1), pp.85. ⟨10.1186/1475-2840-13-85⟩. ⟨inserm-00989533⟩

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