Skip to Main content Skip to Navigation
Journal articles

Powers of the likelihood ratio test and the correlation test using empirical bayes estimates for various shrinkages in population pharmacokinetics.

Abstract : We compared the powers of the likelihood ratio test (LRT) and the Pearson correlation test (CT) from empirical Bayes estimates (EBEs) for various designs and shrinkages in the context of nonlinear mixed-effect modeling. Clinical trial simulation was performed with a simple pharmacokinetic model with various weight (WT) effects on volume (V). Data sets were analyzed with NONMEM 7.2 using first-order conditional estimation with interaction and stochastic approximation expectation maximization algorithms. The powers of LRT and CT in detecting the link between individual WT and V or clearance were computed to explore hidden or induced correlations, respectively. Although the different designs and variabilities could be related to the large shrinkage of the EBEs, type 1 errors and powers were similar in LRT and CT in all cases. Power was mostly influenced by covariate effect size and, to a lesser extent, by the informativeness of the design. Further studies with more models are needed.
Complete list of metadatas

Cited literature [24 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00978660
Contributor : François Combes <>
Submitted on : Monday, April 14, 2014 - 2:56:30 PM
Last modification on : Friday, October 23, 2020 - 4:52:00 PM
Long-term archiving on: : Monday, July 14, 2014 - 11:50:31 AM

Identifiers

Citation

François Combes, Sylvie Retout, Nicolas Frey, France Mentré. Powers of the likelihood ratio test and the correlation test using empirical bayes estimates for various shrinkages in population pharmacokinetics.. CPT: Pharmacometrics and Systems Pharmacology, American Society for Clinical Pharmacology and Therapeutics ; International Society of Pharmacometrics, 2014, 3, pp.e109. ⟨10.1038/psp.2014.5⟩. ⟨inserm-00978660⟩

Share

Metrics

Record views

486

Files downloads

891