Relationship between CT air trapping criteria and lung function in small airway impairment quantification.

Sébastien Bommart 1, 2, * Grégory Marin 3 Arnaud Bourdin 2, 4 Nicolas Molinari 3 François Klein 2 Maurice Hayot 2, 5 Isabelle Vachier 4 Pascal Chanez 6 Jacques Mercier 2, 5 Hélène Vernhet-Kovacsik 2
* Auteur correspondant
1 Imagerie Arnaud de Villeneuve
2 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
3 Statistiques
4 Service des Maladies Respiratoires [Montpellier]
5 Service de Physiologie Clinique
6 Service des Maladies Respiratoires [Marseille]
Abstract : BACKGROUND: Small airways are regarded as the elective anatomic site of obstruction in most chronic airway diseases. Expiratory computed tomography (CT) is increasingly used to assess obstruction at this level but there is no consensus regarding the best quantification method. We aimed to evaluate software-assisted CT quantification of air trapping for assessing small airway obstruction and determine which CT criteria better predict small airway obstruction on single breath nitrogen test (SBNT). METHODS: Eighty-nine healthy volunteers age from 60 to 90 years old, underwent spirometrically-gated inspiratory (I) and expiratory (E) CT and pulmonary function tests (PFTs) using SBNT, performed on the same day. Air trapping was estimated using dedicated software measuring on inspiratory and expiratory CT low attenuation area (LAA) lung proportion and mean lung density (MLD). CT indexes were compared to SBNT results using the Spearman correlation coefficient and hierarchical dendrogram analysis. In addition, receiver operating characteristic (ROC) curve analysis was performed to determine the optimal CT air-trapping criterion. RESULTS: 43 of 89 subjects (48,3%) had dN2 value above the threshold defining small airway obstruction (i.e. 2.5% N2/l). Expiratory to inspiratory MLD ratio (r = 0.40) and LAA for the range -850 -1024 HU (r = 0.29) and for the range -850 -910 HU (r = 0.37) were positively correlated with SBNT results. E/I MLD was the most suitable criterion for its expression. Expiratory to inspiratory MLD ratio (E/I MLD) showed the highest AUC value (0.733) for small airway obstruction assessment. CONCLUSION: Among all CT criteria, all correlating with small airway obstruction on SBNT, E/I MLD was the most suitable criterion for its expression in asymptomatic subjects with mild small airway obstruction TRIAL REGISTRATION: Registered at Clinicaltrials.gov, identifier: NCT01230879.
Keywords : Air trapping Bronchiole Single breath nitrogen test Biomarker Software-assisted CT quantification
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Article dans une revue
BMC Pulmonary Medicine, BioMed Central, 2014, 14 (1), pp.29. 〈10.1186/1471-2466-14-29〉
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http://www.hal.inserm.fr/inserm-00973201
Contributeur : Ed. Bmc <>
Soumis le : vendredi 4 avril 2014 - 09:06:54
Dernière modification le : lundi 27 août 2018 - 09:44:38
Document(s) archivé(s) le : vendredi 4 juillet 2014 - 10:46:25

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Sébastien Bommart, Grégory Marin, Arnaud Bourdin, Nicolas Molinari, François Klein, et al.. Relationship between CT air trapping criteria and lung function in small airway impairment quantification.. BMC Pulmonary Medicine, BioMed Central, 2014, 14 (1), pp.29. 〈10.1186/1471-2466-14-29〉. 〈inserm-00973201〉

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