G. Bazzoni and E. Dejana, Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis, Physiological Reviews, vol.84, issue.3, pp.869-901, 2004.
DOI : 10.1152/physrev.00035.2003

E. Dejana, Endothelial cell???cell junctions: happy together, Nature Reviews Molecular Cell Biology, vol.5, issue.4, pp.261-270, 2004.
DOI : 10.1038/nrm1357

E. Dejana and C. Giampietro, Vascular endothelial-cadherin and vascular stability, Current Opinion in Hematology, vol.19, issue.3, pp.218-223, 2012.
DOI : 10.1097/MOH.0b013e3283523e1c

C. Kirkpatrick and M. Peifer, Not just glue: cell-cell junctions as cellular signaling centers, Current Opinion in Genetics & Development, vol.5, issue.1, pp.56-65, 1995.
DOI : 10.1016/S0959-437X(95)90054-3

U. Cavallaro, S. Liebner, and E. Dejana, Endothelial cadherins and tumor angiogenesis, Experimental Cell Research, vol.312, issue.5, pp.659-667, 2006.
DOI : 10.1016/j.yexcr.2005.09.019

M. Takeichi, The cadherins: cell-cell adhesion molecules controlling animal morphogenesis, Development, vol.102, pp.639-655, 1988.

K. Hatta and M. Takeichi, Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development, Nature, vol.97, issue.6061, pp.447-449, 1986.
DOI : 10.1038/320447a0

Y. Pouliot, P. Holland, and O. Blaschuk, Developmental regulation of a cadherin during the differentiation of skeletal myoblasts, Developmental Biology, vol.141, issue.2, pp.292-298, 1990.
DOI : 10.1016/0012-1606(90)90385-V

L. Derycke and M. Bracke, N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling, The International Journal of Developmental Biology, vol.48, issue.5-6, pp.463-476, 2004.
DOI : 10.1387/ijdb.041793ld

G. Radice, H. Rayburn, H. Matsunami, K. Knudsen, M. Takeichi et al., Developmental Defects in Mouse Embryos Lacking N-Cadherin, Developmental Biology, vol.181, issue.1, pp.64-78, 1997.
DOI : 10.1006/dbio.1996.8443

P. Carmeliet, M. Lampugnani, L. Moons, F. Breviario, V. Compernolle et al., Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis, Cell, vol.98, issue.2, pp.147-157, 1999.
DOI : 10.1016/S0092-8674(00)81010-7

A. Gentil-dit-maurin, S. Oun, S. Almagro, S. Bouillot, M. Courcon et al., Unraveling the distinct distributions of VE- and N-cadherins in endothelial cells: A key role for p120-catenin, Experimental Cell Research, vol.316, issue.16, pp.2587-2599, 2010.
DOI : 10.1016/j.yexcr.2010.06.015

C. Giampietro, A. Taddei, M. Corada, G. Sarra-ferraris, M. Alcalay et al., Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells, Blood, vol.119, issue.9, pp.2159-2170, 2012.
DOI : 10.1182/blood-2011-09-381012

Y. Luo and G. Radice, N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis, The Journal of Cell Biology, vol.128, issue.1, pp.29-34, 2005.
DOI : 10.1038/35025215

V. Vassilev, M. Mandai, S. Yonemura, and M. Takeichi, Loss of N-Cadherin from the Endothelium Causes Stromal Edema and Epithelial Dysgenesis in the Mouse Cornea, Investigative Opthalmology & Visual Science, vol.53, issue.11, pp.7183-7193, 2012.
DOI : 10.1167/iovs.12-9949

D. Fougerolles, A. Stacker, S. Schwarting, R. Springer, and T. , Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1, Journal of Experimental Medicine, vol.174, issue.1, pp.253-267, 1991.
DOI : 10.1084/jem.174.1.253

M. Huang, J. Mason, G. Birdsey, V. Amsellem, N. Gerwin et al., Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis, Blood, vol.106, issue.5, pp.1636-1643, 2005.
DOI : 10.1182/blood-2004-12-4716

J. Bradley, S. Thiru, and J. Pober, Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules, Am J Pathol, vol.147, pp.627-641, 1995.

J. Xie, R. Li, P. Kotovuori, C. Vermot-desroches, J. Wijdenes et al., Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain, J Immunol, vol.155, pp.3619-3628, 1995.

M. Huang, K. Larbi, C. Scheiermann, A. Woodfin, N. Gerwin et al., ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration, Blood, vol.107, issue.12, pp.4721-4727, 2006.
DOI : 10.1182/blood-2005-11-4683

L. Heiska, C. Kantor, T. Parr, D. Critchley, P. Vilja et al., Binding of the cytoplasmic domain of intercellular adhesion molecule-2 (ICAM-2) to alpha-actinin, J BiolChem, vol.271, pp.26214-26219, 1996.

S. Yonemura, M. Hirao, Y. Doi, N. Takahashi, T. Kondo et al., Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2, The Journal of Cell Biology, vol.149, issue.4, pp.885-895, 1998.
DOI : 10.1083/jcb.120.2.437

S. Louvet-vallee, ERM proteins: From cellular architecture to cell signaling, Biology of the Cell, vol.92, issue.5, pp.305-316, 2000.
DOI : 10.1016/S0248-4900(00)01078-9

R. Williams, S. Courtneidge, and E. Wagner, Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene, Cell, vol.52, pp.121-131, 1988.

L. Heiska, K. Alfthan, M. Gronholm, P. Vilja, A. Vaheri et al., Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2), Regulation by phosphatidylinositol J BiolChem, vol.4, issue.273, pp.5-21893, 1998.

K. Hatanaka, M. Simons, and M. Murakami, Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation, AJP: Heart and Circulatory Physiology, vol.300, issue.1, pp.162-172, 2011.
DOI : 10.1152/ajpheart.00650.2010

O. Perez, S. Kinoshita, Y. Hitoshi, D. Payan, T. Kitamura et al., Activation of the PKB/AKT Pathway by ICAM-2, Immunity, vol.16, issue.1, pp.51-65, 2002.
DOI : 10.1016/S1074-7613(02)00266-2

K. Hamada, T. Shimizu, S. Yonemura, S. Tsukita, S. Tsukita et al., Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex, The EMBO Journal, vol.22, issue.3, pp.502-514, 2003.
DOI : 10.1093/emboj/cdg039

V. Braga, L. Machesky, A. Hall, and N. Hotchin, The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell???Cell Contacts, The Journal of Cell Biology, vol.11, issue.6, pp.1421-1431, 1997.
DOI : 10.1016/S0955-0674(96)80050-0

K. Takaishi, T. Sasaki, H. Kotani, H. Nishioka, and Y. Takai, Regulation of Cell???Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells, The Journal of Cell Biology, vol.11, issue.4, pp.1047-1059, 1997.
DOI : 10.1083/jcb.120.2.477

B. Wojciak-stothard, A. Entwistle, R. Garg, and A. Ridley, Regulation of TNF-??-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells, Journal of Cellular Physiology, vol.267, issue.1, pp.150-165, 1998.
DOI : 10.1002/(SICI)1097-4652(199807)176:1<150::AID-JCP17>3.0.CO;2-B

M. Quinlan, Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation, Oncogene, vol.18, issue.47, pp.6434-6442, 1999.
DOI : 10.1038/sj.onc.1203026

M. Del-pozo, M. Vicente-manzanares, R. Tejedor, J. Serrador, and F. Sanchez-madrid, Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes, Eur J Immunol, vol.29, pp.3609-3620, 1999.

E. Auvinen, N. Kivi, and A. Vaheri, Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells, Experimental Cell Research, vol.313, issue.4, pp.824-833, 2007.
DOI : 10.1016/j.yexcr.2006.12.002

B. Wojciak-stothard, S. Potempa, T. Eichholtz, and A. Ridley, Rho and Rac but not Cdc42 regulate endothelial cell permeability, J Cell Sci, vol.114, pp.1343-1355, 2001.

V. Spindler, N. Schlegel, and J. Waschke, Role of GTPases in control of microvascular permeability, Cardiovascular Research, vol.87, issue.2, pp.243-253, 2010.
DOI : 10.1093/cvr/cvq086

P. Navarro, L. Ruco, and E. Dejana, Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization, The Journal of Cell Biology, vol.102, issue.6, pp.1475-1484, 1998.
DOI : 10.1074/jbc.272.21.13463

M. Jaggi, M. Wheelock, and K. Johnson, Differential Displacement of Classical Cadherins by VE-Cadherin, Cell Communication & Adhesion, vol.67, issue.8, pp.103-115, 2002.
DOI : 10.1023/A:1011319507155

D. Ferreri, F. Minnear, T. Yin, A. Kowalczyk, and P. Vincent, N-Cadherin Levels in Endothelial Cells Are Regulated by Monolayer Maturity and p120 Availability, Cell Communication & Adhesion, vol.26, issue.4, pp.333-349, 2008.
DOI : 10.1158/1078-0432.CCR-03-0262

N. Gerwin, J. Gonzalo, C. Lloyd, A. Coyle, Y. Reiss et al., Prolonged Eosinophil Accumulation in Allergic Lung Interstitium of ICAM-2-Deficient Mice Results in Extended Hyperresponsiveness, Immunity, vol.10, issue.1, pp.9-19, 1999.
DOI : 10.1016/S1074-7613(00)80002-3

R. Lyck, Y. Reiss, N. Gerwin, J. Greenwood, P. Adamson et al., T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells, Blood, vol.102, issue.10, pp.3675-3683, 2003.
DOI : 10.1182/blood-2003-02-0358

D. Salomon, O. Ayalon, R. Patel-king, R. Hynes, and B. Geiger, Extrajunctional distribution of N-cadherin in cultured human endothelial cells, J Cell Sci, vol.102, pp.7-17, 1992.

M. Lampugnani, M. Corada, P. Andriopoulou, S. Esser, W. Risau et al., Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells, J Cell Sci, vol.110, pp.2065-2077, 1997.

R. Heymann, I. About, U. Lendahl, J. Franquin, B. Obrink et al., E- and N-Cadherin Distribution in Developing and Functional Human Teeth under Normal and Pathological Conditions, The American Journal of Pathology, vol.160, issue.6, pp.2123-2133, 2002.
DOI : 10.1016/S0002-9440(10)61161-3

T. Nakashima, C. Huang, D. Liu, K. Kameyama, D. Masuya et al., Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients, British Journal of Cancer, vol.88, issue.11, pp.1727-1733, 2003.
DOI : 10.1038/sj.bjc.6600955

L. Derycke, L. Morbidelli, M. Ziche, D. Wever, O. Bracke et al., Soluble N-cadherin fragment promotes angiogenesis, Clinical & Experimental Metastasis, vol.109, issue.3-4, pp.187-201, 2006.
DOI : 10.1007/s10585-006-9029-7

URL : http://hdl.handle.net/1854/LU-351771

S. Koh, J. Cheng, R. Dodson, C. Ku, and C. Abbondandolo, VIP down-regulates the inflammatory potential and promotes survival of dying (neural crest-derived) corneal endothelial cells ex vivo: necrosis to apoptosis switch and up-regulation of Bcl-2 and N-cadherin, pp.792-806, 2009.

M. Nakagawa, M. Fukata, M. Yamaga, N. Itoh, and K. Kaibuchi, Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites, J Cell Sci, vol.114, pp.1829-1838, 2001.

N. Noren, C. Niessen, B. Gumbiner, and K. Burridge, Cadherin Engagement Regulates Rho family GTPases, Journal of Biological Chemistry, vol.276, issue.36, pp.33305-33308, 2001.
DOI : 10.1074/jbc.C100306200

Y. Takai and H. Nakanishi, Nectin and afadin: novel organizers of intercellular junctions, Journal of Cell Science, vol.116, issue.1, pp.17-27, 2003.
DOI : 10.1242/jcs.00167

M. Corada, L. Zanetta, F. Orsenigo, F. Breviario, M. Lampugnani et al., A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability, Blood, vol.100, issue.3, pp.905-911, 2002.
DOI : 10.1182/blood.V100.3.905

E. Lidington, R. Rao, F. Marelli-berg, P. Jat, D. Haskard et al., Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2 K(b)-tsA58 mice, Am J Physiol Cell Physiol, vol.282, pp.67-74, 2002.

E. Jaffe, R. Nachman, C. Becker, and C. Minick, Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA, Journal of Clinical Investigation, vol.52, issue.11, pp.2745-2756, 1973.
DOI : 10.1172/JCI107470

A. Santel, M. Aleku, O. Keil, J. Endruschat, V. Esche et al., RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy, Gene Therapy, vol.23, issue.18, pp.1360-1370, 2006.
DOI : 10.1038/sj.gt.3302778

F. Gavins and B. Chatterjee, Intravital microscopy for the study of mouse microcirculation in anti-inflammatory drug research: Focus on the mesentery and cremaster preparations, Journal of Pharmacological and Toxicological Methods, vol.49, issue.1, pp.1-14, 2004.
DOI : 10.1016/S1056-8719(03)00057-1

B. Chatterjee, S. Yona, G. Rosignoli, R. Young, S. Nourshargh et al., Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro, Journal of Leukocyte Biology, vol.78, issue.3, pp.639-646, 2005.
DOI : 10.1189/jlb.0405206

X. Ren and M. Schwartz, Determination of GTP loading on Rho, Methods Enzymol, vol.325, pp.264-272, 2000.
DOI : 10.1016/S0076-6879(00)25448-7

. Amsellem, ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling, Cell Communication and Signaling, vol.12, issue.1, p.12, 2014.
DOI : 10.1016/S1056-8719(03)00057-1

URL : https://hal.archives-ouvertes.fr/inserm-00973193