The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

Shaden Khalifa; Philippe De Medina; Anna Erlandsson; Hesham El-Seedi; Sandrine Silvente-Poirot; Marc Poirot

doi:10.1016/j.bbrc.2013.12.134

The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

Shaden Khalifa ¹ Philippe De Medina ^{2, 3, 4} Anna Erlandsson ⁵ Hesham El-Seedi ⁶ Sandrine Silvente-Poirot ^{2, 3, 7} Marc Poirot ^{2, 3, 7}

1 Department of Neuroscience

2 CRCT - Centre de Recherche en Cancérologie de Toulouse

3 UPS - Université Toulouse III - Paul Sabatier

4 Chimie

5 Department of Public Health and Caring Sciences

6 Department of Medicinal Chemistry

7 Institut Claudius Regaud

Abstract : Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain.

keyword : Neural stem cells Neurosteroids Oxysterols Dendrogenin

Type de document :

Article dans une revue

Biochemical and Biophysical Research Communications, Elsevier, 2014, 446 (3), pp.681-6. 〈10.1016/j.bbrc.2013.12.134〉

Domaine :

Sciences du Vivant [q-bio] / Sciences pharmaceutiques

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https://www.hal.inserm.fr/inserm-00968932
Contributeur : Marc Poirot <>
Soumis le : mardi 1 avril 2014 - 18:44:51
Dernière modification le : mardi 6 novembre 2018 - 16:04:07

The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

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