The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells. - Archive ouverte HAL Access content directly
Journal Articles Biochemical and Biophysical Research Communications Year : 2014

The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

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Abstract

Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain.
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Dates and versions

inserm-00968932 , version 1 (01-04-2014)

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Shaden A. M. Khalifa, Philippe de Médina, Anna Erlandsson, Hesham R. El-Seedi, Sandrine Silvente-Poirot, et al.. The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.. Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.681-6. ⟨10.1016/j.bbrc.2013.12.134⟩. ⟨inserm-00968932⟩
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