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Aurora B -TACC1 protein complex in cytokinesis.

Abstract : Taxins are a family of centrosomal proteins important for the regulation of mitosis and microtubule dynamics. Cytokinesis, the last step of M phase, is essential for chromosomal integrity and cell division. It is highly regulated and involves a reorganization of microtubules and actin filaments. We show here that TACC1 localizes diffusely to the midzone spindle in anaphase and strongly to the midbody during cytokinesis, indicating a possible involvement of this protein in the exit of M phase. TACC1 also relocalizes to the nucleolus in interphase. We demonstrate that TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. We further show that Aurora B knocked down by RNA-mediated interference prevents the formation of the midbody - and consequently affects TACC1 localization at this site - and leads to abnormal cell division and multinucleated cells.
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https://www.hal.inserm.fr/inserm-00966547
Contributor : Claude Prigent <>
Submitted on : Wednesday, March 26, 2014 - 5:24:41 PM
Last modification on : Tuesday, November 24, 2020 - 4:42:03 PM

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Bénédicte Delaval, Alexia Ferrand, Nathalie Conte, Christian Larroque, Danièle Hernandez-Verdun, et al.. Aurora B -TACC1 protein complex in cytokinesis.. Oncogene, Nature Publishing Group, 2004, 23 (26), pp.4516-22. ⟨10.1038/sj.onc.1207593⟩. ⟨inserm-00966547⟩

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