Aurora B -TACC1 protein complex in cytokinesis.

Bénédicte Delaval 1 Alexia Ferrand 1 Nathalie Conte 1 Christian Larroque 2 Danièle Hernandez-Verdun 3 Claude Prigent 4 Daniel Birnbaum 1
1 Cancérologie expérimentale
2 CRLC Val d'Aurelle-Paul Lamarque
3 IJM - Institut Jacques Monod
4 Génétique et Développement
Abstract : Taxins are a family of centrosomal proteins important for the regulation of mitosis and microtubule dynamics. Cytokinesis, the last step of M phase, is essential for chromosomal integrity and cell division. It is highly regulated and involves a reorganization of microtubules and actin filaments. We show here that TACC1 localizes diffusely to the midzone spindle in anaphase and strongly to the midbody during cytokinesis, indicating a possible involvement of this protein in the exit of M phase. TACC1 also relocalizes to the nucleolus in interphase. We demonstrate that TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. We further show that Aurora B knocked down by RNA-mediated interference prevents the formation of the midbody - and consequently affects TACC1 localization at this site - and leads to abnormal cell division and multinucleated cells.
Keywords : Aurora kinase cell division cytokinesis microtubule midbody TACC protein Taxin RNAi
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Article dans une revue
Oncogene, Nature Publishing Group, 2004, 23 (26), pp.4516-22. 〈10.1038/sj.onc.1207593〉
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Contributeur : Claude Prigent <>
Soumis le : mercredi 26 mars 2014 - 17:24:41
Dernière modification le : mercredi 16 mai 2018 - 11:23:33

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Bénédicte Delaval, Alexia Ferrand, Nathalie Conte, Christian Larroque, Danièle Hernandez-Verdun, et al.. Aurora B -TACC1 protein complex in cytokinesis.. Oncogene, Nature Publishing Group, 2004, 23 (26), pp.4516-22. 〈10.1038/sj.onc.1207593〉. 〈inserm-00966547〉

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