Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

Stéphanie Dutertre; Claude Prigent

doi:10.1124/mi.3.3.127

Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

Stéphanie Dutertre ¹ Claude Prigent ¹

Abstract : The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistance to spindle-checkpoint-targeting drugs such as paclitaxel (Taxol). Indeed, a recent publication by Anand et al. indicates that overexpression of AURORA-A may interfere with spindle-microtubule attachment and disrupt the regulation of the spindle checkpoint by allowing cells with abnormal chromosomal separation to enter anaphase. Thus, the design of new drugs that specifically target aurora-A rather than other checkpoint proteins might alleviate the resistance to Taxol-like clinical therapeutics observed in some tumors.

Type de document :

Article dans une revue

Molecular Interventions, American Society for Pharmacology and Experimental Therapeutics, 2003, 3 (3), pp.127-30. 〈10.1124/mi.3.3.127〉

Domaine :

Sciences du Vivant [q-bio] / Biologie cellulaire

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00966541
Contributeur : Claude Prigent <>
Soumis le : mercredi 26 mars 2014 - 17:09:31
Dernière modification le : mercredi 16 mai 2018 - 11:23:33

Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

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Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

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