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Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

Abstract : The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistance to spindle-checkpoint-targeting drugs such as paclitaxel (Taxol). Indeed, a recent publication by Anand et al. indicates that overexpression of AURORA-A may interfere with spindle-microtubule attachment and disrupt the regulation of the spindle checkpoint by allowing cells with abnormal chromosomal separation to enter anaphase. Thus, the design of new drugs that specifically target aurora-A rather than other checkpoint proteins might alleviate the resistance to Taxol-like clinical therapeutics observed in some tumors.
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https://www.hal.inserm.fr/inserm-00966541
Contributor : Claude Prigent <>
Submitted on : Wednesday, March 26, 2014 - 5:09:31 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:33 AM

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Stéphanie Dutertre, Claude Prigent. Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.. Molecular Interventions, American Society for Pharmacology and Experimental Therapeutics, 2003, 3 (3), pp.127-30. ⟨10.1124/mi.3.3.127⟩. ⟨inserm-00966541⟩

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