Skip to Main content Skip to Navigation
Journal articles

[Progesterone and preterm delivery: Back to the future?].

Abstract : Progesterone was widely used in France during the 1980s and 1990s to prevent preterm birth until some published cases of cholestasis suddenly stopped its prescription. Since then, multiple randomized controlled trials have emerged and demonstrated the efficiency of the treatment but also its safety at low doses. In order to clarify its indications, we performed a current literature review. We analyzed literature data according to different categories of risk and different routes of administration. Results confirm that progesterone is an efficient treatment to prevent preterm birth in singleton gestation with short cervical length, and in singleton gestation with prior preterm birth with or without short cervical length. Apart from these indications, progesterone, especially 17-alpha-hydroxyprogesterone (17OHP), should not be used outside research protocols.
Document type :
Journal articles
Complete list of metadatas

Cited literature [51 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00960303
Contributor : Florent Fuchs <>
Submitted on : Monday, March 17, 2014 - 11:02:48 PM
Last modification on : Wednesday, September 16, 2020 - 5:06:56 PM
Long-term archiving on: : Monday, April 10, 2017 - 1:06:01 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Florent Fuchs, François Audibert, Marie-Victoire Senat. [Progesterone and preterm delivery: Back to the future?].. Gynécologie Obstétrique & Fertilité, Elsevier Masson, 2014, 42 (2), pp.112-22. ⟨10.1016/j.gyobfe.2013.12.006⟩. ⟨inserm-00960303⟩

Share

Metrics

Record views

556