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Journal articles
The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.
Abstract : HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology. Although both viruses replicate in the T cells of infected patients, only HIV-2 replicates efficiently in dendritic cells (DCs) and activates innate immune pathways. How HIV is sensed in DC is unknown. Capsid-mutated HIV-2 revealed that sensing by the host requires viral cDNA synthesis, but not nuclear entry or genome integration. The HIV-1 capsid prevented viral cDNA sensing up to integration, allowing the virus to escape innate recognition. In contrast, DCs sensed capsid-mutated HIV-1 and enhanced stimulation of T cells in the absence of productive infection. Finally, we found that DC sensing of HIV-1 and HIV-2 required the DNA sensor cGAS. Thus, the HIV capsid is a determinant of innate sensing of the viral cDNA by cGAS in dendritic cells. This pathway might potentially be harnessed to develop effective vaccines against HIV-1.
Cited literature [19 references]
https://www.hal.inserm.fr/inserm-00959028
Contributor : Georges Guellaen Connect in order to contact the contributor
Submitted on : Thursday, March 13, 2014 - 5:07:26 PM
Last modification on : Tuesday, December 8, 2020 - 3:37:06 AM
Long-term archiving on: : Sunday, April 9, 2017 - 11:58:19 PM
Contributor : Georges Guellaen Connect in order to contact the contributor
Submitted on : Thursday, March 13, 2014 - 5:07:26 PM
Last modification on : Tuesday, December 8, 2020 - 3:37:06 AM
Long-term archiving on: : Sunday, April 9, 2017 - 11:58:19 PM
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