Idiopathic eosinophilic pneumonia in children: the French experience.

Lisa Giovannini-Chami 1, 2, * Alice Hadchouel 3 Nadia Nathan 4, 5 François Brémont 6 Jean-Christophe Dubus 7 Michael Fayon 8, 9 Véronique Houdouin 10 Michèle Berlioz-Baudoin 1 Virginie Feret 8, 9 Thierry Leblanc 11 Karine Morelle 6 Marc Albertini 1, 2 Annick Clement 3, 5 Jacques De Blic 3
* Auteur correspondant
1 Service de Pneumologie Allergologie pédiatriques
2 UNS - Université Nice Sophia Antipolis
3 Service de Pneumologie Allergologie [CHU Necker]
4 CR Saint-Antoine - Centre de Recherche Saint-Antoine
5 Service de pneumologie
6 Pédiatrie - Pneumologie, Allergologie
7 Service de pneumologie pédiatrique
8 Service de pneumologie pédiatrique
9 CIC - Bordeaux
10 Service de pneumologie pédiatrique
11 Service d'hématologie et immunologie pédiatrique
Abstract : BACKGROUND: Idiopathic eosinophilic pneumonia is extremely rare in children and adults. We present herein the first series describing the specificities of idiopathic chronic (ICEP) and acute (IAEP) eosinophilic pneumonia in children. METHODS: We retrospectively analyzed all cases of ICEP and IAEP in children that were retrieved from French Reference Centers for rare pediatric lung diseases. RESULTS: Five cases of pediatric ICEP were identified. Corticosteroid or immunosuppressive therapy dramatically improved the outcome in three cases. The remaining two cases had a persistent interstitial pattern with progressive development of cystic airspace lesions. Three cases of IAEP in adolescents were reported, with one requiring four days of extracorporeal membrane oxygenation. CONCLUSION: ICEP is a rare disease with a polymorphic clinical presentation in children. We identified patients with persistent interstitial patterns progressing to cystic airspace regions, for which the boundaries with idiopathic interstitial pneumonias are difficult to establish. We therefore propose a specific pediatric definition and classification algorithm. IAEP in children remains an inflammatory reaction of the lung to an acute toxic exposure, mainly tobacco, as in adults. International studies are required to comprehensively assess the various clinical forms of the disease as well as the appropriate therapeutic regimens.
Keywords : Idiopathic chronic eosinophilic pneumonia Idiopathic acute eosinophilic pneumonia Child Eosinophilic lung disease Interstitial lung disease
Type de document :
Article dans une revue
Orphanet Journal of Rare Diseases, BioMed Central, 2014, 9 (1), pp.28. 〈10.1186/1750-1172-9-28〉
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Dernière modification le : vendredi 31 août 2018 - 09:13:22
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Lisa Giovannini-Chami, Alice Hadchouel, Nadia Nathan, François Brémont, Jean-Christophe Dubus, et al.. Idiopathic eosinophilic pneumonia in children: the French experience.. Orphanet Journal of Rare Diseases, BioMed Central, 2014, 9 (1), pp.28. 〈10.1186/1750-1172-9-28〉. 〈inserm-00952981〉

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