Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes. - Archive ouverte HAL Access content directly
Journal Articles Critical Care Year : 2014

Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes.

(1) , (2) , (1) , (3) , (4) , (5) , (6) , (7) , (8) , (9) , (9) , (9) , (9) , (9) , (9) , (1) , (1)
1
2
3
4
5
6
7
8
9
Qin Lu
  • Function : Correspondent author
  • PersonId : 917659

Connectez-vous pour contacter l'auteur
Philippe Eggimann
  • Function : Author
  • PersonId : 953051
Charles-Edouard Luyt
  • Function : Author
  • PersonId : 943529
Michel Wolff
  • Function : Author
  • PersonId : 953052
Michael Tamm
  • Function : Author
  • PersonId : 953053
Emmanuelle Mercier
  • Function : Author
  • PersonId : 832230
Jorge Garbino
  • Function : Author
  • PersonId : 953054
Pierre-François Laterre
  • Function : Author
  • PersonId : 953055
Holger Koch
  • Function : Author
  • PersonId : 953056
Verena Gafner
  • Function : Author
  • PersonId : 953057
Michael Rudolf
  • Function : Author
  • PersonId : 953058
Erkan Mus
  • Function : Author
  • PersonId : 953059
Antonio Perez
  • Function : Author
  • PersonId : 953060
Hedvika Lazar
  • Function : Author
  • PersonId : 953061
Jean Chastre
  • Function : Author
  • PersonId : 953062
Jean-Jacques Rouby
  • Function : Author
  • PersonId : 953063

Abstract

INTRODUCTION: Pseudomonas aeruginosa frequently causes nosocomial pneumonia and is associated with poor outcome. The purpose of this study was to assess the prevalence and clinical outcome of nosocomial pneumonia caused by serotype specific Pseudomonas aeruginosa in critically ill patients under appropriate antimicrobial therapy management. METHODS: A retrospective, non-interventional epidemiological multicenter cohort study involving 143 patients with confirmed nosocomial pneumonia caused by Pseudomonas aeruginosa. Patients were analyzed for a period of 30 days from time of nosocomial pneumonia onset. Fourteen patients fulfilling the same criteria from a Phase IIa study conducted at the same time/centers were included in the prevalence calculations but not in the clinical outcome analysis. RESULTS: The prevalence of serotypes was: O6 (29%), O11 (23%), O10 (10%), O2 (9%) and O1 (8%). Serotypes with a prevalence < 5% were found in 13% of patients, 8% were classified as not typeable. Across all serotypes there was 19% mortality, 70% clinical resolution, 11% clinical continuation and 5% clinical recurrence. Age and higher APACHE II were predictive risk factors associated with probability of death and lower clinical resolution for Pseudomonas aeruginosa nosocomial pneumonia. Mortality tends to be higher with O1 (40%) and lower with O2 (0%); clinical resolution tends to be better with O2 (82%) compared to other serotypes. Persisting pneumonia with O6 and O11 was respectively 8% and 21%; clinical resolution with O6 and O11 was respectively 75% and 57%. CONCLUSIONS: In Pseudomonas aeruginosa nosocomial pneumonia, the most prevalent serotypes were O6 and O11. Further studies including larger group sizes are needed to correlate clinical outcome with virulence factors of Pseudomonas aeruginosa in patients with nosocomial pneumonia caused by various serotypes; and to compare O6 and O11, the 2 serotypes most frequently encountered in critically ill patients.
Fichier principal
Vignette du fichier
cc13697.pdf (261.14 Ko) Télécharger le fichier
Vignette du fichier
cc13697.xml (99.77 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00950094 , version 1 (20-02-2014)

Identifiers

Cite

Qin Lu, Philippe Eggimann, Charles-Edouard Luyt, Michel Wolff, Michael Tamm, et al.. Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes.. Critical Care, 2014, 18 (1), pp.R17. ⟨10.1186/cc13697⟩. ⟨inserm-00950094⟩
464 View
245 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More