Surface smoothing: a way back in early brain morphogenesis.

Julien Lefèvre; Victor Intwali; Lucie Hertz-Pannier; Petra Hüppi; Jean-Francois Mangin; Jessica Dubois; David Germanaud

Surface smoothing: a way back in early brain morphogenesis.

Julien Lefèvre ^{1, *} Victor Intwali ² Lucie Hertz-Pannier ^{3, 4} Petra Hüppi ⁵ Jean-Francois Mangin ⁴ Jessica Dubois ⁶ David Germanaud ^{3, 4}

* Corresponding author

1 LSIS - Laboratoire des Sciences de l'Information et des Systèmes

2 Sciences de l'ingénieur

3 U1129 - Epilepsies de l'Enfant et Plasticité Cérébrale

4 LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur

5 Child Development Disorders

6 UNICOG-U992 - Neuroimagerie cognitive

Abstract : In this article we propose to investigate the analogy between early cortical folding process and cortical smoothing by mean curvature flow. First, we introduce a one-parameter model that is able to fit a developmental trajectory as represented in a Volume-Area plot and we propose an efficient optimization strategy for parameter estimation. Second, we validate the model on forty cortical surfaces of preterm newborns by comparing global geometrical indices and trajectories of central sulcus along developmental and simulation time.

Document type :

Journal articles

Domain :

Computer Science [cs] / Modeling and Simulation

Computer Science [cs] / Medical Imaging

Life Sciences [q-bio] / Human health and pathology / Pediatrics

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https://www.hal.inserm.fr/inserm-00944650
Contributor : Julien Lefèvre <>
Submitted on : Monday, February 10, 2014 - 9:09:22 PM
Last modification on : Thursday, April 11, 2019 - 4:02:24 PM
Long-term archiving on : Monday, May 12, 2014 - 1:20:13 PM

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Surface smoothing: a way back in early brain morphogenesis.

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Surface smoothing: a way back in early brain morphogenesis.

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