Robust estimation of the cerebral blood flow in arterial spin labelling

Camille Maumet 1 Pierre Maurel 2 Jean-Christophe Ferré 3 Christian Barillot 1
1 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
2 Medesis Pharma
3 UNIROUEN - UFR Santé
Abstract : The introduction of Arterial Spin Labelling (ASL) techniques in Magnetic Resonance Imaging (MRI) has made feasible a non-invasive measurement of the Cerebral Blood Flow (CBF). However, to date, the low signal-to-noise ratio of ASL gives us no option but to repeat the acquisition to accumulate enough data in order to get a reliable signal. The perfusion signal is then usually extracted by averaging across the repetitions. But the sample mean is very sensitive to outliers. A single incorrect observation can therefore be the source of strong detrimental effects on the perfusion-weighted image estimated with the sample mean. We propose to estimate robust ASL CBF maps with M-estimators to overcome the deleterious effects of outliers. The behaviour of this method is compared to z-score thresholding as recommended in [1]. Validation on simulated and real data is provided. Quantitative validation is undertaken by measuring the correlation with the most widespread technique to measure perfusion with MRI: Dynamic Susceptibility weighted Contrast imaging.
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Camille Maumet, Pierre Maurel, Jean-Christophe Ferré, Christian Barillot. Robust estimation of the cerebral blood flow in arterial spin labelling. Magnetic Resonance Imaging, Elsevier, 2014, 32 (5), pp.497 - 504. ⟨10.1016/j.mri.2014.01.016⟩. ⟨inserm-00942814⟩

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