Skip to Main content Skip to Navigation
Journal articles

An overview of cardiac morphogenesis.

Abstract : Accurate knowledge of normal cardiac development is essential for properly understanding the morphogenesis of congenital cardiac malformations that represent the most common congenital anomaly in newborns. The heart is the first organ to function during embryonic development and is fully formed at 8 weeks of gestation. Recent studies stemming from molecular genetics have allowed specification of the role of cellular precursors in the field of heart development. In this article we review the different steps of heart development, focusing on the processes of alignment and septation. We also show, as often as possible, the links between abnormalities of cardiac development and the main congenital heart defects. The development of animal models has permitted the unraveling of many mechanisms that potentially lead to cardiac malformations. A next step towards a better knowledge of cardiac development could be multiscale cardiac modelling.
Document type :
Journal articles
Complete list of metadatas

Cited literature [58 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00941964
Contributor : Lotfi Senhadji <>
Submitted on : Tuesday, February 4, 2014 - 3:20:58 PM
Last modification on : Thursday, March 5, 2020 - 6:38:54 PM
Long-term archiving on: : Monday, May 5, 2014 - 6:40:51 AM

File

_165R1_NS.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Jean-Marc Schleich, Tariq Abdulla, Ron Summers, Lucile Houyel. An overview of cardiac morphogenesis.. Archives of cardiovascular diseases, Elsevier/French Society of Cardiology, 2013, 106 (11), pp.612-23. ⟨10.1016/j.acvd.2013.07.001⟩. ⟨inserm-00941964⟩

Share

Metrics

Record views

463

Files downloads

828