Dynamical models of biomarkers and clinical progression for personalized medicine: the HIV context.

Abstract : Mechanistic models, based on ordinary differential equation systems, can exhibit very good predictive abilities that will be useful to build treatment monitoring strategies. In this review, we present the potential and the limitations of such models for guiding treatment (monitoring and optimizing) in HIV-infected patients. In the context of antiretroviral therapy, several biological processes should be considered in addition to the interaction between viruses and the host immune system: the mechanisms of action of the drugs, their pharmacokinetics and pharmacodynamics, as well as the viral and host characteristics. Another important aspect to take into account is clinical progression, although its implementation in such modelling approaches is not easy. Finally, the control theory and the use of intrinsic properties of mechanistic models make them very relevant for dynamic treatment adaptation. Their implementation would nevertheless require their evaluation through clinical trials.
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Advanced Drug Delivery Reviews, Elsevier, 2013, 65 (7), pp.954-65. 〈10.1016/j.addr.2013.04.004〉
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http://www.hal.inserm.fr/inserm-00939450
Contributeur : Rodolphe Thiebaut <>
Soumis le : jeudi 30 janvier 2014 - 17:20:31
Dernière modification le : mercredi 29 novembre 2017 - 14:54:22

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Mélanie Prague, Daniel Commenges, Rodolphe Thiébaut. Dynamical models of biomarkers and clinical progression for personalized medicine: the HIV context.. Advanced Drug Delivery Reviews, Elsevier, 2013, 65 (7), pp.954-65. 〈10.1016/j.addr.2013.04.004〉. 〈inserm-00939450〉

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