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The minimal clinically important difference determined using item response theory models: an attempt to solve the issue of the association with baseline score.

Abstract : OBJECTIVES: Determining the minimal clinically important difference (MCID) of questionnaires on an interval scale, the trait level (TL) scale, using item response theory (IRT) models could overcome its association with baseline severity. The aim of this study was to compare the sensitivity (Se), specificity (Sp), and predictive values (PVs) of the MCID determined on the score scale (MCID-Sc) or the TL scale (MCID-TL). STUDY DESIGN AND SETTING: The MCID-Sc and MCID-TL of the MOS-SF36 general health subscale were determined for deterioration and improvement on a cohort of 1,170 patients using an anchor-based method and a partial credit model. The Se, Sp, and PV were calculated using the global rating of change (the anchor) as the gold standard test. RESULTS: The MCID-Sc magnitude was smaller for improvement (1.58 points) than for deterioration (-7.91 points). The Se, Sp, and PV were similar for MCID-Sc and MCID-TL in both cases. However, if the MCID was defined on the score scale as a function of a range of baseline scores, its Se, Sp, and PV were consistently higher. CONCLUSION: This study reinforces the recommendations concerning the use of an MCID-Sc defined as a function of a range of baseline scores.
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https://www.hal.inserm.fr/inserm-00936664
Contributor : Alexandra Rouquette <>
Submitted on : Monday, January 27, 2014 - 10:57:06 AM
Last modification on : Wednesday, September 16, 2020 - 4:54:11 PM
Long-term archiving on: : Sunday, April 27, 2014 - 10:31:42 PM

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Alexandra Rouquette, Myriam Blanchin, Véronique Sébille, Francis Guillemin, Sylvana Côté, et al.. The minimal clinically important difference determined using item response theory models: an attempt to solve the issue of the association with baseline score.. Journal of Clinical Epidemiology, Elsevier, 2014, 67 (4), pp.433-40. ⟨10.1016/j.jclinepi.2013.10.009⟩. ⟨inserm-00936664⟩

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