M. Kivipelto, T. Ngandu, T. Laatikainen, B. Winblad, H. Soininen et al., Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study, The Lancet Neurology, vol.5, issue.9, pp.735-776, 2006.
DOI : 10.1016/S1474-4422(06)70537-3

A. Buchman, P. Boyle, L. Yu, R. Shah, R. Wilson et al., Total daily physical activity and the risk of AD and cognitive decline in older adults, Neurology, vol.78, issue.17, pp.1323-1332, 2012.
DOI : 10.1212/WNL.0b013e3182535d35

J. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers et al., Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nature Genetics, vol.12, issue.10, pp.1094-1103, 2009.
DOI : 10.1038/ng.439

P. Hollingworth, D. Harold, R. Sims, A. Gerrish, J. Lambert et al., Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease, Nature Genetics, vol.41, issue.5, pp.429-464, 2011.
DOI : 10.1038/ng.2007.16

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173

C. Brayne, N. Best, M. Muir, S. Richards, and C. Gill, Five-year incidence and prediction of dementia and cognitive decline in a population sample of women aged 70-79 at baseline, International Journal of Geriatric Psychiatry, vol.7, issue.11, pp.1107-1125, 1997.
DOI : 10.1002/(SICI)1099-1166(199711)12:11<1107::AID-GPS695>3.0.CO;2-9

Y. Yoshitake, Y. Kiyohara, I. Kato, T. Ohmura, H. Iwamoto et al., Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study, Neurology, vol.45, issue.6, pp.1161-1169, 1995.
DOI : 10.1212/WNL.45.6.1161

W. Kukull, R. Higdon, J. Bowen, W. Mccormick, L. Teri et al., Dementia and Alzheimer Disease Incidence, Archives of Neurology, vol.59, issue.11, pp.1737-1783, 2002.
DOI : 10.1001/archneur.59.11.1737

L. Barnes, R. Wilson, J. Schneider, J. Bienias, D. Evans et al., Gender, cognitive decline, and risk of AD in older persons, Neurology, vol.60, issue.11, pp.1777-81, 2003.
DOI : 10.1212/01.WNL.0000065892.67099.2A

L. Hebert, P. Scherr, J. Mccann, L. Beckett, and D. Evans, Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?, American Journal of Epidemiology, vol.153, issue.2, pp.132-138, 2001.
DOI : 10.1093/aje/153.2.132

R. Miech, J. Breitner, P. Zandi, A. Khachaturian, J. Anthony et al., Incidence of AD may decline in the early 90s for men, later for women: The Cache County study, Neurology, vol.58, issue.2, pp.209-227, 2002.
DOI : 10.1212/WNL.58.2.209

E. Paykel, C. Brayne, F. Huppert, C. Gill, C. Barkley et al., Incidence of Dementia in a Population Older Than 75 Years in the United Kingdom, Archives of General Psychiatry, vol.51, issue.4, pp.325-357, 1994.
DOI : 10.1001/archpsyc.1994.03950040069009

D. Bachman, P. Wolf, R. Linn, J. Knoefel, J. Cobb et al., Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study, Neurology, vol.43, issue.3, Part 1, pp.515-524, 1993.
DOI : 10.1212/WNL.43.3_Part_1.515

W. Rocca, R. Cha, S. Waring, and E. Kokmen, Incidence of dementia and Alzheimer's disease: A reanalysis of data from Rochester, Minnesota, AmJEpidemiol, vol.148, pp.51-62, 1975.

K. Andersen, L. Launer, M. Dewey, L. Letenneur, A. Ott et al., Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies, Neurology, vol.53, issue.9, pp.1992-1999, 1999.
DOI : 10.1212/WNL.53.9.1992

A. Ruitenberg, A. Ott, J. Hofman, A. Breteler, and M. , Incidence of dementia: does gender make a difference?, Neurobiology of Aging, vol.22, issue.4, pp.575-80, 2001.
DOI : 10.1016/S0197-4580(01)00231-7

R. Petersen, R. Roberts, D. Knopman, Y. Geda, R. Cha et al., Prevalence of mild cognitive impairment is higher in men: The Mayo Clinic Study of Aging, Neurology, vol.75, issue.10, pp.889-97, 2010.
DOI : 10.1212/WNL.0b013e3181f11d85

R. Roberts, Y. Geda, D. Knopman, R. Cha, V. Pankratz et al., The incidence of MCI differs by subtype and is higher in men: The Mayo Clinic Study of Aging, Neurology, vol.78, issue.5, pp.342-51, 2012.
DOI : 10.1212/WNL.0b013e3182452862

E. Luders, H. Steinmetz, and L. Jancke, Brain size and grey matter volume in the healthy human brain, NeuroReport, vol.13, issue.17, pp.2371-2375, 2002.
DOI : 10.1097/00001756-200212030-00040

Y. Ge, R. Grossman, J. Babb, M. Rabin, L. Mannon et al., Age-related total gray matter and white matter changes in normal adult brain. Part I: Volumetric MR imaging analysis, AmerJNeuroradiol, vol.23, pp.1327-1360, 2002.

M. Ikram, H. Vrooman, M. Vernooij, T. Heijer, A. Hofman et al., Brain tissue volumes in relation to cognitive function and risk of dementia, Neurobiology of Aging, vol.31, issue.3, pp.31378-86, 2010.
DOI : 10.1016/j.neurobiolaging.2008.04.008

C. Smith, H. Chebrolu, D. Wekstein, F. Schmitt, and W. Markesbery, Age and gender effects on human brain anatomy: A voxel-based morphometric study in healthy elderly, Neurobiology of Aging, vol.28, issue.7, pp.1075-87, 2007.
DOI : 10.1016/j.neurobiolaging.2006.05.018

T. Rabinowicz, D. Dean, and J. Petetot, Gender Differences in the Human Cerebral Cortex: More Neurons in Males; More Processes in Females, Journal of Child Neurology, vol.179, issue.2, pp.98-107, 1999.
DOI : 10.1177/088307389901400207

H. Wolf, P. Julin, H. Gertz, B. Winblad, and L. Wahlund, Intracranial volume in mild cognitive impairment, Alzheimer's disease and vascular dementia: evidence for brain reserve?, IntJGeriatrPsychiatry, vol.19, pp.995-1007, 2004.

B. Nugent and M. Mccarthy, Epigenetic Underpinnings of Developmental Sex Differences in the Brain, Neuroendocrinology, vol.93, issue.3, pp.150-158, 2011.
DOI : 10.1159/000325264

A. Polleri, M. Gianelli, and G. Murialdo, Dementia: A neuroendocrine perspective, Journal of Endocrinological Investigation, vol.23, issue.1, pp.73-83, 2002.
DOI : 10.1007/BF03343964

D. Kimura, Sex, sexual orientation and sex hormones influence human cognitive function, Current Opinion in Neurobiology, vol.6, issue.2, pp.259-63, 1996.
DOI : 10.1016/S0959-4388(96)80081-X

Y. Stern, Cognitive reserve in ageing and Alzheimer's disease, The Lancet Neurology, vol.11, issue.11, pp.1006-1018, 2012.
DOI : 10.1016/S1474-4422(12)70191-6

R. Wilson, D. Weir, S. Leurgans, D. Evans, L. Hebert et al., Sources of variability in estimates of the prevalence of Alzheimer???s disease in the United States, Alzheimer's & Dementia, vol.7, issue.1, pp.74-83, 2011.
DOI : 10.1016/j.jalz.2010.11.006

D. Knopman, S. Dekosky, J. Cummings, H. Chui, J. Corey-bloom et al., Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology, Neurology, vol.56, issue.9, pp.1143-53, 2001.
DOI : 10.1212/WNL.56.9.1143

T. Dawber, G. Meadors, F. Moore, and J. , Epidemiological Approaches to Heart Disease: The Framingham Study, American Journal of Public Health and the Nations Health, vol.41, issue.3, pp.279-81, 1951.
DOI : 10.2105/AJPH.41.3.279

W. Kannel, M. Feinleib, P. Mcnamara, R. Garrison, and W. Castelli, AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES, American Journal of Epidemiology, vol.110, issue.3, pp.281-90, 1979.
DOI : 10.1093/oxfordjournals.aje.a112813

A. Association, Diagnostic and Statistical Manual of Mental Disorders: DSM-IV American Psychiatric Association, 1994.

G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price et al., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, vol.34, issue.7, pp.939-983, 1984.
DOI : 10.1212/WNL.34.7.939

D. Lee, P. Gona, I. Albano, M. Larson, E. Benjamin et al., A Systematic Assessment of Causes of Death After Heart Failure Onset in the Community: Impact of Age at Death, Time Period, and Left Ventricular Systolic Dysfunction, Circulation: Heart Failure, vol.4, issue.1, pp.36-43, 2011.
DOI : 10.1161/CIRCHEARTFAILURE.110.957480

W. Kannel, C. Kannel, R. Paffenbarger, J. Cupples, and L. , Heart rate and cardiovascular mortality: The Framingham study, American Heart Journal, vol.113, issue.6, pp.1489-94, 1987.
DOI : 10.1016/0002-8703(87)90666-1

A. Chobanian, G. Bakris, H. Black, W. Cushman, L. Green et al., The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. The JNC 7 report, ACC Current Journal Review, vol.12, issue.4, pp.2560-72, 2003.
DOI : 10.1016/S1062-1458(03)00270-8

A. Beiser, D. Agostino, R. Sr, S. Seshadri, L. Sullivan et al., Epidemiology: Computing Estimates of Incidence, Including Lifetime Risk: Alzheimer's Disease in the Framingham Study. The Practical Incidence Estimators (PIE) Macro, StatMed, vol.19, pp.1495-522, 2000.
DOI : 10.1002/0470023678.ch1a

D. Leys, H. Henon, M. Mackowiak-cordoliani, and F. Pasquier, Poststroke dementia, The Lancet Neurology, vol.4, issue.11, pp.752-759, 2005.
DOI : 10.1016/S1474-4422(05)70221-0

W. Rocca, A. Hofman, C. Brayne, M. Breteler, M. Clarke et al., Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980-1990 prevalence findings, Annals of Neurology, vol.70, issue.Suppl 1, pp.381-90, 1991.
DOI : 10.1002/ana.410300310

M. Corrada, R. Brookmeyer, D. Berlau, A. Paganini-hill, and C. Kawas, Prevalence of dementia after age 90: Results from The 90+ Study, Neurology, vol.71, issue.5, pp.337-380, 2008.
DOI : 10.1212/01.wnl.0000310773.65918.cd

L. Fratiglioni, M. Viitanen, V. Strauss, E. Tontodonati, V. Herlitz et al., Very Old Women at Highest Risk of Dementia and Alzheimer's Disease: Incidence Data from the Kungsholmen Project, Stockholm, Neurology, vol.48, issue.1, pp.132-140, 1997.
DOI : 10.1212/WNL.48.1.132

J. Schneider, N. Aggarwal, L. Barnes, P. Boyle, and D. Bennett, The Neuropathology of Older Persons with and Without Dementia from Community versus Clinic Cohorts, Journal of Alzheimer's Disease, vol.18, issue.3, pp.691-701, 2009.
DOI : 10.3233/JAD-2009-1227

L. White, B. Small, H. Petrovitch, G. Ross, K. Masaki et al., Recent Clinical-Pathologic Research on the Causes of Dementia in Late Life: Update From the Honolulu-Asia Aging Study, Journal of Geriatric Psychiatry and Neurology, vol.91, issue.4, pp.224-231, 2005.
DOI : 10.1177/0891988705281872

I. Skoog, C. Hesse, O. Aeversson, S. Landahl, J. Wahlstrom et al., A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality, Journal of Neurology, Neurosurgery & Psychiatry, vol.64, issue.1, pp.37-43, 1998.
DOI : 10.1136/jnnp.64.1.37

D. Snowdon, L. Greiner, J. Mortimer, K. Riley, P. Greiner et al., Brain infarction and the clinical expression of Alzheimer disease. The Nun Study, JAMA: The Journal of the American Medical Association, vol.277, issue.10, pp.813-820, 1997.
DOI : 10.1001/jama.277.10.813

J. Schneider, R. Wilson, J. Bienias, D. Evans, and D. Bennett, Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology, Neurology, vol.62, issue.7, pp.1148-55, 2004.
DOI : 10.1212/01.WNL.0000118211.78503.F5

M. Kivipelto, E. Helkala, A. Nissinen, H. Soininen, and J. Tuomilehto, Vascular risk factors, ApoE ?4 allele, and gender and the risk of Alzheimer's disease: perspectives on prevention, Drug Development Research, vol.57, issue.2, pp.85-94, 2002.
DOI : 10.1002/ddr.10064

R. Kloppenborg, B. Van-den, L. Kappelle, and G. Biessels, Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review, European Journal of Pharmacology, vol.585, issue.1, pp.97-108, 2008.
DOI : 10.1016/j.ejphar.2008.02.049

B. Caracciolo, K. Palmer, R. Monastero, B. Winblad, L. Backman et al., Occurrence of cognitive impairment and dementia in the community: A 9-year-long prospective study, Neurology, vol.70, issue.Issue 19, Part 2, pp.1778-85, 2008.
DOI : 10.1212/01.wnl.0000288180.21984.cb

M. Albert, J. Massaro, C. Decarli, A. Beiser, S. Seshadri et al., Profiles by Sex of Brain MRI and Cognitive Function in the Framingham Offspring Study, Alzheimer Disease & Associated Disorders, vol.24, issue.2, pp.190-193, 2010.
DOI : 10.1097/WAD.0b013e3181c1ed44

M. Rusanen, S. Rovio, T. Ngandu, A. Nissinen, J. Tuomilehto et al., Midlife Smoking, Apolipoprotein E and Risk of Dementia and Alzheimer???s Disease: A Population-Based Cardiovascular Risk Factors, Aging and Dementia Study, Dementia and Geriatric Cognitive Disorders, vol.30, issue.3, pp.277-84, 2010.
DOI : 10.1159/000320484

W. Xu, C. Qiu, M. Gatz, N. Pedersen, B. Johansson et al., Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study, Diabetes, vol.58, issue.1, pp.71-78, 2009.
DOI : 10.2337/db08-0586

M. Power, J. Weuve, J. Gagne, M. Mcqueen, A. Viswanathan et al., The Association Between Blood Pressure and Incident Alzheimer Disease, Epidemiology, vol.22, issue.5, pp.646-59, 2011.
DOI : 10.1097/EDE.0b013e31822708b5

D. Barnes and K. Yaffe, The projected effect of risk factor reduction on Alzheimer's disease prevalence, The Lancet Neurology, vol.10, issue.9, pp.819-847, 2011.
DOI : 10.1016/S1474-4422(11)70072-2