Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.

Geneviève Chêne 1, * Alexa Beiser 2, 3 Rhoda Au 2 Sarah Preis 3 Philip Wolf 2 Carole Dufouil 1 Sudha Seshadri 2
* Auteur correspondant
1 Epidémiologie et Biostatistique [Bordeaux]
2 Neurology Department
3 Department of Biostatistics
Abstract : BACKGROUND: Gender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown. METHODS: Prospectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]). RESULTS: Overall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in women older than 85 years of age. LTR of dementia/AD at age 45 was 1 in 5 in women and 1 in 10 in men. Cardiovascular mortality was higher in men with rate ratios decreasing from approximately 6 at 45 to 54 years of age to less than 2 after age 65. CONCLUSION: Selective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women.
Keywords : incidence of dementia Alzheimer's disease gender mortality cardiovascular risk profile selective survival cohort/population-based cohort prevention
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Article dans une revue
Alzheimer's and Dementia, Elsevier, 2014, epub ahead of print. 〈10.1016/j.jalz.2013.10.005〉
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Soumis le : lundi 27 janvier 2014 - 09:40:45
Dernière modification le : mercredi 29 novembre 2017 - 14:54:21
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Geneviève Chêne, Alexa Beiser, Rhoda Au, Sarah Preis, Philip Wolf, et al.. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.. Alzheimer's and Dementia, Elsevier, 2014, epub ahead of print. 〈10.1016/j.jalz.2013.10.005〉. 〈inserm-00936580〉

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