 |
Journal articles
Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.
Abstract : BACKGROUND: Gender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown. METHODS: Prospectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]). RESULTS: Overall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in women older than 85 years of age. LTR of dementia/AD at age 45 was 1 in 5 in women and 1 in 10 in men. Cardiovascular mortality was higher in men with rate ratios decreasing from approximately 6 at 45 to 54 years of age to less than 2 after age 65. CONCLUSION: Selective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women.
Cited literature [54 references]
https://www.hal.inserm.fr/inserm-00936580
Contributor : Evelyne Mouillet <>
Submitted on : Monday, January 27, 2014 - 9:40:45 AM
Last modification on : Friday, August 2, 2019 - 4:38:11 PM
Long-term archiving on: : Sunday, April 27, 2014 - 10:23:09 PM
Contributor : Evelyne Mouillet <>
Submitted on : Monday, January 27, 2014 - 9:40:45 AM
Last modification on : Friday, August 2, 2019 - 4:38:11 PM
Long-term archiving on: : Sunday, April 27, 2014 - 10:23:09 PM
Files
Chene_Seshadri_ADJ-D-13-00064R...
Files produced by the author(s)